Injectable controlled release fluid delivery system

• US 8,906,000 B2
• Filed: 10/18/2007
• Issued: 12/09/2014
• Est. Priority Date: 11/09/2005
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Wood, Lowell L. Jr., Tegreene, Clarence T., Gates, William H. III, Hyde, Roderick A.
• Primary Examiner(s): Berdichevsky, Aarti B
• Assistant Examiner(s): OSINSKI, BRADLEY JAMES
• Application Number:
  US11/975,729
• Publication Number:
  US 20080132881A1
• Time in Patent Office: 2,609 Days
• Field of Search: 604/890.1, 604/93.01, 604131-133, 604 65- 67, 604/892.1, 60428801-28804, 604/891.1
• US Class Current: 604/891.1
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 2205/0266 Shape memory materials
• CPC Class Codes: A61M 2205/3515 using magnetic means
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/825 using mechanical generation of electricity, e.g. hand cranked generators
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons
• CPC Class Codes: A61M 5/148 flexible, e.g. independent bagsA61M5/155 takes precedence
• CPC Class Codes: A61M 5/1483 using flexible bags externally pressurised by fluid pressure
• CPC Class Codes: A61M 5/152 pressurised by contraction of elastic reservoirs containers for dispensing contents by contraction of an elastic bag provided therein, in general B65D83/0061
• CPC Class Codes: A61M 5/16813 by controlling the degree of opening of the flow line

Abstract

Embodiments of a material delivery device including a deformable reservoir and associated controllable output mechanism are described. Methods of use and control of the device are also disclosed. According to some embodiments, a material delivery device may be placed in an animal in order to controllably dispense at least one material into the animal. The material delivery device may include a programmable mechanism to control the release of the material into the animal. In selected embodiments, a remote controller may be used to program or to control the material delivery device. Some embodiments are described wherein a magnetic field, an electric field, or electromagnetic control signal may be used.

Claims

1. A material delivery kit, comprising:

at least one percutaneous injection mechanism including a syringe;

at least one material delivery device enclosed in the syringe, the at least one material delivery device configured for percutaneous injection into an animal using the at least one injection mechanism, the at least one material delivery device including;

at least one collapsible reservoir having a biologically inert collapsible outer surface, the collapsible reservoir configured to receive, retain and controllably release at least one material from the at least one collapsible reservoir; and

at least one controllable output mechanism coupled to the at least one collapsible reservoir and defining at least one outlet through which the at least one material may be released, the at least one controllable output mechanism including at least one control circuitry configured to activate the at least one controllable output mechanism and configured to control the release of the at least one material from the at least one collapsible reservoir and through the at least one outlet; and

wherein the at least one controllable output mechanism includes at least one thermally-responsive gel or magnetically-responsive material.

2. The kit of claim 1, further comprising at least one remote controller configured to generate and transmit at least one control signal to the at least one material delivery device.

3. The kit of claim 2, wherein the at least one remote controller comprises at least one of hardware, firmware, or software configured to control transmission of the at least one control signal.

4. The kit of claim 1, further comprising at least one delivery material.

5. The kit of claim 4, wherein the at least one delivery material comprises at least one therapeutic agent.

6. The kit of claim 5, wherein the at least one therapeutic agent comprises an immunogenic amount of at least one vaccine.

7. The kit of claim 5, wherein the at least one therapeutic agent includes a therapeutically effective amount of at least one anti-infective agent.

8. The kit of claim 7, wherein the at least one anti-infective agent includes at least one anti-viral agent.

9. The kit of claim 7, wherein the at least one anti-infective agent includes at least one anti-microbial agent.

10. The kit of claim 5, wherein the at least one therapeutic agent includes a therapeutically effective amount of at least one agent to treat malaria.

11. The kit of claim 5, wherein the at least one therapeutic agent includes a therapeutically effective amount of at least one agent to treat tuberculosis.

12. The kit of claim 5, wherein the at least one therapeutic agent includes a therapeutically effective amount of at least one agent to treat leschmaniasis.

13. The kit of claim 5, wherein the at least one therapeutic agent includes a therapeutically effective amount of at least one agent to treat cholera.

14. The kit of claim 5, wherein the at least one therapeutic agent includes a therapeutically effective amount of at least one agent to treat diphtheria.

15. The kit of claim 4, wherein the at least one delivery material is a fluid.

16. The kit of claim 1, wherein the at least one material delivery device further comprises at least one inlet mechanism for receiving external delivery of at least one material.

17. The kit of claim 1, wherein the at least one material delivery device includes RFID electrical circuitry.

18. The kit of claim 1, wherein the at least one material delivery device further comprises at least one sensor, at least one timer, or at least one counter.

19. The kit of claim 18, wherein the at least one sensor is located on the at least one material delivery device.

20. The kit of claim 1, wherein the at least one material delivery device further comprises hardware, firmware or software configured to control the at least one controllable output mechanism.

21. The kit of claim 1, wherein the at least one material delivery device further comprises at least one electronic memory location for recording information.

22. The kit of claim 1, wherein the at least one controllable output mechanism includes a MEMS device or a NEMS device.

23. The kit of claim 1, wherein the at least one thermally or magnetically responsive material includes at least one of a ferropolymer, a hydrogel, or an artificial muscle.

24. The kit of claim 1, wherein the at least one controllable output mechanism defines the at least one outlet, and a base housing that supports the at least one collapsible reservoir and includes the at least one control circuitry therein.

25. A material delivery kit, comprising:

at least one percutaneous injection mechanism including a syringe;

at least one material delivery device enclosed in the syringe, the at least one material delivery device configured for percutaneous injection into an animal using the at least one injection mechanism, the at least one material delivery device including;

at least one collapsible reservoir having a biologically inert collapsible outer surface, the collapsible reservoir configured to receive, retain and controllably release at least one material, including at least one outlet through which the at least one material may be released from the at least one collapsible reservoir; and

at least one controllable output mechanism operably linked to said at least one outlet including at least one control circuitry configured to activate the at least one controllable output mechanism and configured to control the release of the at least one material from the at least one collapsible reservoir; and

wherein the at least one controllable output mechanism includes at least one thermally-responsive gel.