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Immunonanotherapeutics that provide IGG humoral response without T-cell antigen

  • US 8,906,381 B2
  • Filed: 10/09/2009
  • Issued: 12/09/2014
  • Est. Priority Date: 10/12/2008
  • Status: Active Grant
First Claim
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1. A composition comprising:

  • (1) synthetic nanocarriers comprising;

    (a) an immunofeature surface formed of an array of binding moieties, the array having high avidity and low affinity binding to antigen presenting cells as compared to antibody binding,(b) a B-cell antigen, and(c) immunostimulatory agent, wherein the nanocarriers comprise substantially no T-helper antigen; and

    (2) a pharmaceutically acceptable excipient.

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