Antimicrobial medical devices containing chlorhexidine free base and salt

• US 8,906,401 B2
• Filed: 02/04/2013
• Issued: 12/09/2014
• Est. Priority Date: 12/22/2000
• Status: Expired due to Fees

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Modak, Shanta M., Sampath, Lester A.
• Primary Examiner(s): AZPURU, CARLOS A
• Application Number:
  US13/758,686
• Publication Number:
  US 20130150452A1
• Time in Patent Office: 673 Days
• Field of Search: None
• US Class Current: 424/423
• CPC Class Codes: A61K 31/155 Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 9/7023 Transdermal patches and similar drug-containing composite devices, e.g. cataplasms galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 2300/206 Biguanides, e.g. chlorohexidine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C09D 175/04 Polyurethanes

Abstract

The present disclosure invention relates to medical devices treated with a solution comprising one or more solvents and a combination of chlorhexidine free base and a water-soluble chlorhexidine salt in a weight/weight ratio of between about 1:1 to about 1:5, preferably about 1:1.

Claims

1. An antimicrobial medical article prepared by treating a hydrophobic polymeric medical article, for an effective period of time, with a solution consisting essentially of one or more solvents and a mixture of chlorhexidine free base and a water-soluble chlorhexidine salt, wherein the weight/weight ratio of chlorhexidine free base and the water-soluble chlorhexidine salt in the solution is between 1:

1 to 1;

5.

2. The antimicrobial medical article of claim 1, wherein the article is expanded polytetrafluoroethylene.

3. The antimicrobial medical article of claim 1, wherein the article is a polytetrafluoroethylene soft tissue patch.

4. A method of preparing a medical article comprising the steps of:

(i) placing the medical article in a solution consisting essentially of (a) a solvent selected from the group consisting of water, reagent alcohol, tetrahydrofuran, dimethylsulfoxide, dimethylformamide, N-methyl-2-pyrrolidone, and mixtures thereof; and

(b) a mixture of chlorhexidine free base and a water-soluble chlorhexidine salt, wherein the weight/weight ratio of chlorhexidine free base and water-soluble chlorhexidine salt in the solution is between 1;

1 to 1;

5;

(ii) soaking the medical article in the solution for an effective period of time to allow the medical article to swell;

(iii) removing the medical article from the solution; and

(iv) drying the medical article.

5. The method of claim 4, wherein the medical article is a hydrophobic polymeric medical article.

6. The method of claim 5, wherein the hydrophobic polymeric medical article is selected from the group consisting of expanded polytetrafluoroethylene and a polytetrafluoroethylene soft tissue patch.