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Modified human four helical bundle polypeptides and their uses

  • US 8,907,064 B2
  • Filed: 10/18/2007
  • Issued: 12/09/2014
  • Est. Priority Date: 02/02/2004
  • Status: Active Grant
First Claim
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1. An isolated four helical bundle (4HB) polypeptide chosen from the group consisting of human growth hormone, interferon, erythropoietin, and granulocyte cell stimulating factor, comprising a ribosomally incorporated para-acetylphenylalanine wherein said para-acetylphenylalanine is substituted at the C-terminus, wherein the 4HB polypeptide with a non-naturally encoded amino acid has at least a 2-fold increased serum half-life over the wild type 4HB polypeptide.

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