System to treat AV-conducted ventricular tachyarrhythmia

• US 8,909,337 B2
• Filed: 05/17/2012
• Issued: 12/09/2014
• Est. Priority Date: 04/05/2005
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Moffitt, Julia, Kramer, Andrew P., Libbus, Imad
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): Patel, Natasha
• Application Number:
  US13/473,774
• Publication Number:
  US 20120232604A1
• Time in Patent Office: 936 Days
• Field of Search: 607/14, 607/37, 607/4, 607/9, 607/7, 607/62, 607/118, 607/119, 607/148
• US Class Current: 607/9
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61N 1/0587 Epicardial electrode systems; Endocardial electrodes piercing the pericardium
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation
• CPC Class Codes: A61N 1/39622 Pacing therapy
• CPC Class Codes: A61N 2001/0585 Coronary sinus electrodes

Abstract

Various aspects of the present subject matter provide devices and methods to treat AV-conducted ventricular tachyarrhythmia (AVCVT). According to various embodiments of the method, an AVCVT is sensed, an IVC-LA fat pad is stimulated when the AVCVT is sensed to block AV conduction, and bradycardia support pacing is provided while the IVC-LA fat pad is stimulated. Other aspects and embodiments are provided herein.

Claims

1. An implantable medical device, comprising:

pacing circuitry configured to provide bradycardia support pacing to maintain a minimum heart rate;

an atrial rate detector configured to detect an atrial rate;

a neural stimulation circuit configured to apply neural stimulation to an interior vena cava-left atrium (IVC-LA) fat pad; and

a controller operably connected to the pacing circuitry, the atrial rate detector and the neural stimulation circuit, wherein the controller is configured to control the neural stimulation circuit to deliver neural stimulation to the IVC-LA fat pad on condition that the detected atrial rate exceeds a programmable threshold programmed into the implantable medical device.

2. The device of claim 1, wherein the atrial rate detector is configured to sense an intrinsic signal from a right atrium.

3. The device of claim 1, further comprising a ventricular rate detector configured to detect a ventricular rate.

4. The device of claim 3, wherein the ventricular rate detector is configured to sense an intrinsic signal from the right ventricle.

5. The device of claim 3, wherein the controller is configured to compare the detected ventricular rate and the detected atrial rate, and control the neural stimulator to deliver neural stimulation to the IVC-LA fat pad based on the comparison.

6. The device of claim 5, wherein the controller is configured to control the neural stimulator to deliver neural stimulation to the IVC-LA fat pad on condition that the detected atrial rate exceeds a threshold and the detected ventricular rate follows the detected atrial rate.

7. The device of claim 3 wherein the pacing circuitry is configured to cooperate with the ventricular rate detector to provide ventricular pacing to maintain the detected ventricular rate at or above a minimum ventricular rate.

8. The device of claim 1, wherein the ventricular rate detector is configured to sense an intrinsic signal in a right ventricle, and the pacing circuitry is configured to pacing the right ventricle.

9. The device of claim 1, wherein the controller is adapted to identify a ventricular refractory period and to control delivery of the neural stimulation based on the ventricular refractory period to avoid capturing ventricular tissue with the neural stimulation.

10. The device of claim 1, wherein the neural stimulation circuit includes an epicardial electrode used to apply the neural stimulation to the IVC-LA fat pad.

11. The device of claim 1, wherein the neural stimulation circuit includes an electrode configured for placement in a coronary sinus used to transvascularly apply the neural stimulation to the IVC-LA fat pad.

12. The device of claim 1, wherein the neural stimulation has a frequency of approximately 30 Hz and a duration of approximately 0.05 ms.

13. The device of claim 1, wherein the controller is configured to adjust the neural stimulation if the atrial rate is not reduced by the neural stimulation.

14. An implantable medical device, comprising:

pacing circuitry configured to provide bradycardia support pacing to maintain a minimum heart rate;

an atrial rate detector configured to detect an atrial rate;

a neural stimulation circuit configured to apply neural stimulation to an inferior vena cava-left atrium (IVC-LA) fat pad;

a shockable event detector configured to detect a cardiac event indicated for an electrical shock to terminate the cardiac event; and

a shock pulse generator configured to electrically shock cardiac tissue; and

a controller operably connected to the shockable event detector, the shock pulse generator, the pacing circuitry, the atrial rate detector and the neural stimulation circuit, wherein the controller is configured to;

respond to a detected cardiac event indicated for the electrical shock by controlling the shock pulse generator to electrically shock cardiac tissue; and

control the neural stimulator to deliver neural stimulation to the IVC-LA fat pad on condition that the detected atrial rate exceeds a programmable threshold programmed into the implantable medical device.

15. The device of claim 14, wherein the controller is adapted to identify a ventricular refractory period and to control delivery of the neural stimulation based on the ventricular refractory period to avoid capturing ventricular tissue with the neural stimulation.

16. The device of claim 14, wherein the neural stimulation circuit includes an epicardial electrode used to apply the neural stimulation to the IVC-LA fat pad.

17. The device of claim 14, wherein the neural stimulation circuit includes an electrode configured for placement in a coronary sinus used to transvascularly apply the neural stimulation to the IVC-LA fat pad.

18. An implantable medical device, comprising:

pacing circuitry configured to provide bradycardia support pacing to maintain a minimum heart rate;

an atrial rate detector configured to sense an intrinsic signal from a right atrium to detect an atrial rate;

a ventricular rate detector configured to sense an intrinsic signal from a right ventricle to detect a ventricular rate;

a neural stimulation circuit configured to apply neural stimulation to an inferior vena cava-left atrium (IVC-LA) fat pad;

a shockable event detector configured to detect a cardiac event indicated for an electrical shock to terminate the cardiac event;

a shock pulse generator configured to electrically shock cardiac tissue; and

a controller operably connected to the shockable event detector, the shock pulse generator, the pacing circuitry, the atrial rate detector and the neural stimulation circuit, wherein the controller is configured to;

respond to a detected cardiac event indicated for the electrical shock by controlling the shock pulse generator to electrically shock cardiac tissue;

control the neural stimulation circuit to deliver neural stimulation to the IVC-LA fat pad on condition that the detected atrial rate exceeds a programmable threshold programmed into the implantable medical device and that the detected ventricular rate follows the detected atrial rate; and

adjust the neural stimulation if the atrial rate is not reduced by the neural stimulation.

19. The device of claim 18, wherein the controller is adapted to identify a ventricular refractory period and to control delivery of the neural stimulation based on the ventricular refractory period to avoid capturing ventricular tissue with the neural stimulation.

20. The device of claim 18, wherein the neural stimulation has a frequency of approximately 30 Hz and a duration of approximately 0.05 ms.