Non-cylindrical mandrels

• US 8,910,555 B2
• Filed: 04/22/2014
• Issued: 12/16/2014
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: Insera Therapeutics, Inc.
• Original Assignee: Insera Therapeutics, Inc.
• Inventors: Janardhan, Vallabh, Janardhan, Vikram
• Primary Examiner(s): Patel, Devang R
• Application Number:
  US14/258,424
• Publication Number:
  US 20140265096A1
• Time in Patent Office: 238 Days
• Field of Search: 87/9, 87/11, 87/34, 606/159, 606/194, 228/47.1, 228/57
• US Class Current: 87/34
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12122 within the heart for closing a cardiac septal defect A61B17/0057
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/22 Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for dilators A61M29/00
• CPC Class Codes: A61B 17/22031 Gripping instruments, e.g. forceps, for removing or smashing calculi A61B17/221 takes precedence
• CPC Class Codes: A61B 17/22032 having inflatable gripping elements balloon catheters A61M25/10
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 17/32056 Surgical snare instruments for removing or smashing calculi A61B2017/2212; tonsillotomes A61B17/26
• CPC Class Codes: A61B 17/3207 Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions A61B17/32037 takes precedence; endoscopic cutting instruments A61B17/320016
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2017/00575 for closure at remote site, e.g. closing atrial septum defects
• CPC Class Codes: A61B 2017/00592 Elastic or resilient implements
• CPC Class Codes: A61B 2017/00606 Implements H-shaped in cross-section, i.e. with occluders on both sides of the opening
• CPC Class Codes: A61B 2017/00641 for closing fistulae, e.g. anorectal fistulae
• CPC Class Codes: A61B 2017/00778 Operations on blood vessels A61B2017/22097, A61B2017/320741 take precedence
• CPC Class Codes: A61B 2017/22001 Angioplasty, e.g. PCTA
• CPC Class Codes: A61B 2017/22002 preventing restenosis
• CPC Class Codes: A61B 2017/22034 for gripping the obstruction or the tissue part from inside
• CPC Class Codes: A61B 2017/22035 for retrieving or repositioning foreign objects
• CPC Class Codes: A61B 2017/22067 : Blocking; Occlusion A61B2017/22054 takes precedence
• CPC Class Codes: A61B 2090/3966 : Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61B 90/39 : Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61F 2/011 : Instruments for their placement or removal
• CPC Class Codes: A61F 2002/018 : made from tubes or sheets of material, e.g. by etching or laser-cutting
• CPC Class Codes: A61M 1/74 : Suction control underwater drainage A61M1/61
• CPC Class Codes: A61M 1/84 : Drainage tubes; Aspiration tips for negative pressure wound therapy A61M1/90; for surgical cutting instruments A61B17/32
• CPC Class Codes: A61M 2025/0042 : Microcatheters, cannula or the like having outside diameters around 1 mm or less
• CPC Class Codes: A61M 2202/06 : Solids
• CPC Class Codes: A61M 2207/10 : Device therefor
• CPC Class Codes: A61M 2210/12 : Blood circulatory system
• CPC Class Codes: A61M 25/0023 : by the form of the lumen, e.g. cross-section, variable diameter
• CPC Class Codes: A61M 25/10 : Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 29/00 : Dilators with or without means for introducing media, e.g. remedies instruments for performing visual medical inspections of cavities or tubes of the body A61B1/00
• CPC Class Codes: B23K 26/083 : Devices involving movement of the workpiece in at least one axial direction
• CPC Class Codes: B23K 26/14 : using a fluid stream, e.g. a jet of gas, in conjunction with the laser beam; Nozzles therefor B23K26/12 takes precedence
• CPC Class Codes: B23K 26/142 : for the removal of by-products
• CPC Class Codes: B23K 26/1435 : involving specially adapted flow control means
• CPC Class Codes: B23K 26/146 : the fluid stream containing a liquid
• CPC Class Codes: B23K 26/20 : Bonding soldering by means of radiant energy B23K1/005; joining of preformed plastics parts by heating using laser beam B29C65/16
• CPC Class Codes: B23K 26/38 : by boring or cutting
• CPC Class Codes: B26F 3/004 : by means of a fluid jet methods for use of abrasive blasting for cutting B24C1/045; guns for abrasive fluid jets B24C5/02; perforating by non-mechanical means, e.g. by fluid jet B26F1/26
• CPC Class Codes: D04C 1/06 : Braid or lace serving particular purposes
• CPC Class Codes: D04C 1/12 : Cords, lines, or tows
• CPC Class Codes: D04C 3/48 : Auxiliary devices
• CPC Class Codes: D10B 2403/0333 : with tubular portions of variable diameter or distinct axial orientation
• CPC Class Codes: D10B 2509/06 : Vascular grafts; stents
• CPC Class Codes: Y10T 137/8376 : Combined
• CPC Class Codes: Y10T 137/85954 : Closed circulating system
• CPC Class Codes: Y10T 156/10 : Methods of surface bonding and/or assembly therefor
• CPC Class Codes: Y10T 29/49913 : by constricting outer annulus
• CPC Class Codes: Y10T 29/49995 : Shaping one-piece blank by removing material
• CPC Class Codes: Y10T 82/2521 : Bar feeder

Abstract

A mandrel for manufacturing a vascular device for treating a vessel includes an elongate strand and a plurality of bulbs coupled to the elongate strand. The elongate strand may extend through each of the plurality of bulbs. The mandrel may include first and second elongate strands each including a plurality of bulbs. The first and second elongate strands may be separable at an intermediate portion coupling the first and second elongate strands. A vascular device manufactured utilizing the mandrel may be configured to treat a vessel.

Claims

1. A mandrel for manufacturing a vascular device for treating a vessel, the mandrel comprising:

an elongate strand having a longitudinal axis;

a first bulb coupled to the elongate strand, the first bulb comprising a first cylindrical hole, the elongate strand extending through the first cylindrical hole;

a second bulb coupled to the elongate strand distal to the first bulb along the longitudinal axis of the elongate strand, the second bulb comprising a second cylindrical hole, the elongate strand extending through the second cylindrical hole, the first bulb and the second bulb having a first outer diameter;

a third bulb coupled to the elongate strand distal to the second bulb along the longitudinal axis of the elongate strand, the third bulb comprising a third cylindrical hole, the elongate strand extending through the third cylindrical hole;

a fourth bulb coupled to the elongate strand distal to the third bulb along the longitudinal axis of the elongate strand, the fourth bulb comprising a fourth cylindrical hole, the elongate strand extending through the fourth cylindrical hole, the third bulb and the fourth bulb having a second outer diameter smaller than the first outer diameter;

a fifth bulb coupled to the elongate strand distal to the fourth bulb along the longitudinal axis of the elongate strand, the fifth bulb comprising a fifth cylindrical hole, the elongate strand extending through the fifth cylindrical hole;

a sixth bulb coupled to the elongate strand distal to the fifth bulb along the longitudinal axis of the elongate strand, the sixth bulb comprising a sixth cylindrical hole, the elongate strand extending through the sixth cylindrical hole;

a seventh bulb coupled to the elongate strand distal to the sixth bulb along the longitudinal axis of the elongate strand, the seventh bulb comprising a seventh cylindrical hole, the elongate strand extending through the seventh cylindrical hole, the fifth bulb, the sixth bulb, and the seventh bulb having a third outer diameter smaller than the second outer diameter;

an eighth bulb coupled to the elongate strand distal to the seventh bulb along the longitudinal axis of the elongate strand, the eighth bulb comprising an eighth cylindrical hole, the elongate strand extending through the eighth cylindrical hole;

a ninth bulb coupled to the elongate strand distal to the eighth bulb along the longitudinal axis of the elongate strand, the ninth bulb comprising a ninth cylindrical hole, the elongate strand extending through the ninth cylindrical hole; and

a tenth bulb coupled to the elongate strand distal to the ninth bulb along the longitudinal axis of the elongate strand, the tenth bulb comprising a tenth cylindrical hole, the elongate strand extending through the tenth cylindrical hole, the eighth bulb, the ninth bulb, and the tenth bulb having a fourth outer diameter smaller than the third outer diameter,

at least one of the first bulb, the second bulb, the third bulb, the fourth bulb, the fifth bulb, the sixth bulb, the seventh bulb, the eighth bulb, the ninth bulb, and the tenth bulb having a spherical shape,

wherein a plurality of the first bulb, the second bulb, the third bulb, the fourth bulb, the fifth bulb, the sixth bulb, the seventh bulb, the eighth bulb, the ninth bulb, and the tenth bulb is coupled to the elongate strand by at least one of welding and soldering,

wherein a vascular device manufactured utilizing the mandrel is configured to treat a vessel.

2. The mandrel of claim 1, wherein the first bulb has an oblong shape, the second bulb has a spherical shape, the third bulb has an oblong shape, the fourth bulb has a spherical shape, the fifth bulb has an oblong shape, the sixth bulb has a spherical shape, the seventh bulb has a spherical shape, the eighth bulb has an oblong shape, the ninth bulb has a spherical shape, and the tenth bulb has a spherical shape.

3. The mandrel of claim 1, wherein the first bulb has a spherical shape, the second bulb has a spherical shape, the third bulb has a spherical shape, the fourth bulb has a spherical shape, the fifth bulb has a spherical shape, the sixth bulb has a spherical shape, the seventh bulb has a spherical shape, the eighth bulb has a spherical shape, the ninth bulb has a spherical shape, and the tenth bulb has a spherical shape.

4. The mandrel of claim 1, wherein at least two of the first bulb, the second bulb, the third bulb, the fourth bulb, the fifth bulb, the sixth bulb, the seventh bulb, the eighth bulb, the ninth bulb, and the tenth bulb have different shapes.

5. The mandrel of claim 1, wherein at least one of the first bulb, the second bulb, the third bulb, the fourth bulb, the fifth bulb, the sixth bulb, the seventh bulb, the eighth bulb, the ninth bulb, and the tenth bulb has an oblong shape.

6. A mandrel for manufacturing a vascular device for treating a vessel, the mandrel comprising:

an elongate stainless steel strand having an outer diameter between 0.15 mm and 0.75 mm; and

a plurality of stainless steel bulbs coupled to the elongate stainless steel strand by at least one of welding and soldering, the elongate stainless steel strand extending through each of the plurality of stainless steel bulbs,

at least one stainless steel bulb of the plurality of stainless steel bulbs having an outer diameter between 2.25 mm and 2.75 mm,

at least one stainless steel bulb of the plurality of stainless steel bulbs having an outer diameter between 2.75 mm and 3.25 mm, and

at least one stainless steel bulb of the plurality of stainless steel bulbs having an outer diameter between 3.25 mm and 4 mm,

wherein a vascular device manufactured utilizing the mandrel is configured to treat a vessel.

7. The mandrel of claim 6, wherein the elongate stainless steel strand has a longitudinal axis and the plurality of stainless steel bulbs are aligned along the longitudinal axis of the elongate stainless steel strand.

8. The mandrel of claim 6, wherein at least one stainless steel bulb of the plurality of stainless steel bulbs has a spherical shape.

9. The mandrel of claim 6, wherein a first stainless steel bulb of the plurality of stainless steel bulbs has a different shape than a second stainless steel bulb of the plurality of stainless steel bulbs.

10. The mandrel of claim 6, wherein at least one stainless steel bulb of the plurality of stainless steel bulbs has an outer diameter between 1.5 mm and 2.25 mm.

11. The mandrel of claim 6, wherein a first stainless steel bulb of the plurality of stainless steel bulbs is spaced from a second stainless steel bulb of the plurality of stainless steel bulbs by a length between 0.25 times and 2 times the outer diameter of the first stainless steel bulb, the first stainless steel bulb proximal to the second stainless steel bulb.

12. The mandrel of claim 6, wherein a first stainless steel bulb of the plurality of stainless steel bulbs is spaced from a second stainless steel bulb of the plurality of stainless steel bulbs by a hypotube having a diameter between 0.15 mm and 0.75 mm.

13. The mandrel of claim 6, wherein the elongate stainless steel strand comprises a separable intermediate portion.

14. The mandrel of claim 6, wherein the plurality of stainless steel bulbs comprises six stainless steel bulbs.

15. The mandrel of claim 6, wherein the plurality of stainless steel bulbs comprises ten stainless steel bulbs.

16. A mandrel for manufacturing a vascular device for treating a vessel, the mandrel comprising:

a first mandrel piece comprising;

a first elongate strand including an uncoupled proximal end and a distal end, and

a first plurality of bulbs coupled to the first elongate strand by at least one of welding and soldering, the first elongate strand extending through each of the first plurality of bulbs,

a second mandrel piece comprising;

a second elongate strand including a proximal end and an uncoupled distal end, and

a second plurality of bulbs coupled to the second elongate strand, the second elongate strand extending through each of the second plurality of bulbs; and

an intermediate portion coupling the distal end of the first elongate strand and the proximal end of the second elongate strand, the first mandrel piece separable from the second mandrel piece in the intermediate portion,

wherein a vascular device manufactured utilizing the mandrel is configured to treat a vessel.

17. The mandrel of claim 16, wherein each of the second plurality of bulbs has an outer diameter greater than an outer diameter of each of the first plurality of bulbs.

18. The mandrel of claim 16, wherein each of the first plurality of bulbs and the second plurality of bulbs has an outer diameter between 1 mm and 6 mm.

19. The mandrel of claim 16, wherein each of the first plurality of bulbs and the second plurality of bulbs has an outer diameter between 4 mm and 10 mm.

20. The mandrel of claim 16, wherein at least one of the first plurality of bulbs has a spherical shape and at least one of the second plurality of bulbs has a spherical shape.