Analyte sensor
First Claim
Patent Images
1. A method for measuring a concentration of an analyte in a vein of a host, the method comprising:
- providing an analyte measuring system comprising a vascular access device, an analyte sensor configured to measure an analyte concentration and configured to reside within the vascular access device, and electronics operatively connected to the sensor and configured to generate a signal associated with the analyte concentration;
placing the vascular access device and the analyte sensor in fluid communication with a vein of a host;
passing a solution past the analyte sensor and measuring a signal associated with an analyte concentration of the solution; and
drawing back a sample volume of from about 1 μ
l to about 15 μ
l from the vein, measuring a signal associated with the analyte concentration of the sample and subsequently returning the sample back to the vein, wherein the vascular access device comprises a catheter and tubing connected to the catheter.
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Abstract
Systems and methods of use for continuous analyte measurement of a host'"'"'s vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host'"'"'s circulatory system.
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Citations
40 Claims
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1. A method for measuring a concentration of an analyte in a vein of a host, the method comprising:
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providing an analyte measuring system comprising a vascular access device, an analyte sensor configured to measure an analyte concentration and configured to reside within the vascular access device, and electronics operatively connected to the sensor and configured to generate a signal associated with the analyte concentration; placing the vascular access device and the analyte sensor in fluid communication with a vein of a host; passing a solution past the analyte sensor and measuring a signal associated with an analyte concentration of the solution; and drawing back a sample volume of from about 1 μ
l to about 15 μ
l from the vein, measuring a signal associated with the analyte concentration of the sample and subsequently returning the sample back to the vein, wherein the vascular access device comprises a catheter and tubing connected to the catheter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method for measuring a concentration of an analyte in a circulatory system of a host, the method comprising:
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providing an analyte measuring system comprising a vascular access device, an analyte sensor configured to measure an analyte concentration, and electronics operatively connected to the analyte sensor and configured to generate a signal associated with the analyte concentration, wherein the analyte sensor is configured to reside within the vascular access device, and wherein the vascular access device and the analyte sensor are configured for fluid communication with the circulatory system; passing a solution past the analyte sensor and measuring a signal associated with an analyte concentration of the solution; and drawing back a sample of from about 1 μ
l to about 15 μ
l from the circulatory system and measuring a signal associated with an analyte concentration of the sample, wherein the analyte measuring system further comprises a flow control device, wherein the flow control device is configured to iteratively control four or more different predetermined flow rates. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23)
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24. A method for measuring a concentration of an analyte in a circulatory system of a host, the method comprising:
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providing an analyte measuring system comprising a vascular access device, an analyte sensor configured to measure an analyte concentration, and electronics operatively connected to the analyte sensor and configured to generate a signal associated with the analyte concentration, wherein the analyte sensor is configured to reside within the vascular access device, and wherein the vascular access device and the analyte sensor are configured for fluid communication with the circulatory system; passing a solution past the analyte sensor and measuring a signal associated with an analyte concentration of the solution; and drawing back a sample from the circulatory system and measuring a signal associated with the analyte concentration of the sample, wherein the analyte measuring system further comprises a flow control device, wherein the flow control device is configured to meter flow during passing and drawing, wherein the flow control device comprises a valve comprising a first discrete position and a second discrete position, wherein passing a solution comprises passing a volume of less than 50 microliters during movement of the valve from the first position to the second position.
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25. A method for measuring a concentration of an analyte in a circulatory system of a host, the method comprising:
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providing an analyte measuring system comprising a vascular access device, an analyte sensor configured to measure an analyte concentration, and electronics operatively connected to the analyte sensor and configured to generate a signal associated with the analyte concentration, wherein the analyte sensor is configured to reside within the vascular access device; placing the vascular access device and the analyte sensor in fluid communication with the circulatory system; passing a solution past the analyte sensor and measuring a signal associated with an analyte concentration of the solution; and drawing back a sample from the circulatory system and measuring a signal associated with an analyte concentration of the sample, wherein drawing back the sample from the circulatory system comprises drawing back the sample into the vascular access device substantially no farther than a plane defined by a skin of the host. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A method for measuring a concentration of an analyte in a vein of a host, the method comprising:
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providing an analyte measuring system comprising a vascular access device, an analyte sensor configured to measure an analyte concentration and configured to reside within the vascular access device, and electronics operatively connected to the sensor and configured to generate a signal associated with the analyte concentration; placing the vascular access device and the analyte sensor in fluid communication with a vein of a host; passing a solution past the analyte sensor and measuring a signal associated with an analyte concentration of the solution; and drawing back a sample volume of from about 25 μ
l to about 150 μ
l from the vein, measuring a signal associated with the analyte concentration of the sample and subsequently returning the sample back to the vein, wherein the vascular access device comprises a catheter and tubing connected to the catheter. - View Dependent Claims (37, 38, 39, 40)
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Specification