Auto-injector

• US 8,911,410 B2
• Filed: 02/16/2011
• Issued: 12/16/2014
• Est. Priority Date: 02/18/2010
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Ekman, Matthew, Barrow-Williams, Timothy Donald, Hourmand, Yannick
• Primary Examiner(s): VU, QUYNH-NHU HOANG
• Application Number:
  US13/579,450
• Publication Number:
  US 20130172822A1
• Time in Patent Office: 1,399 Days
• Field of Search: 604136-137, 604140-143, 604/187, 604192-193, 604197-198, 604/263
• US Class Current: 604/198
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/3204 Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
• CPC Class Codes: A61M 5/3221 Constructional features thereof, e.g. to improve manipulation or functioning
• CPC Class Codes: A61M 5/326 Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user

Abstract

The invention relates to an auto-injector (1) with a delay mechanism (36) for slowing down motion of a retraction sleeve (10) in axial direction of the auto-injector (1), the delay mechanism (36) comprising a circumferential outer wall (37) with a back collar (38) attached to a housing (2) of the auto-injector (1) and a circumferential inner wall (39) with a front collar (40) attached to the retraction sleeve (10) wherein a cavity is defined between the outer wall (37) and inner wall (39), the cavity sealed by the back collar (38) against the inner wall (39) and by the front collar (40) against the outer wall (37), the cavity filled with a viscous fluid, wherein at least one orifice is arranged in the delay mechanism (36) for allowing the viscous fluid to be pushed out as the volume of the cavity decreases due to axial motion of the component with respect to the housing. The retraction sleeve (10) is axially movably arranged in the housing (2) and serves for retracting the syringe (3) with the needle (4) into the covered position after delivering the medicament (M).

Claims

1. Auto-injector for administering a dose of a liquid medicament (M), comprising:

an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament (M), the housing having a distal end (D) and a proximal end (P) with an orifice intended to be applied against an injection site, wherein the syringe is slidably arranged with respect to the housing,

driving means capable of, upon activation;

pushing the needle from a covered position inside the housing into

an advanced position through the orifice and past the proximal end (P) via

a plunger,

operating the syringe to supply the dose of medicament (M) via the

plunger, and

retracting the syringe with the needle into the covered position

after delivering the medicament (M),

a retraction sleeve, axially movably arranged in the housing,

at least one latch for axially fixing the retraction sleeve in a maximum proximal position,

a delay mechanism for slowing down motion of the retraction sleeve in distal direction, the delay mechanism comprising a circumferential outer wall with a back collar attached to the housing and a circumferential inner wall with a front collar attached to the retraction sleeve wherein a cavity is defined between the outer wall and inner wall, the cavity sealed by the back collar against the inner wall and by the front collar against the outer wall, the cavity filled with a viscous fluid, wherein at least one orifice is arranged in the delay mechanism for allowing the viscous fluid to be pushed out as the volume of the cavity decreases due to axial motion of the retraction sleeve with respect to the housing at least one aperture arranged in the retraction sleeve,

wherein the latches are arranged to be disengaged by the decoupling member before the stopper has reached a maximum proximal position in the syringe when moved in proximal direction, wherein the apertures are arranged to meet the decoupling arms after the stopper has reached its maximum proximal position by means of the motion of the retraction sleeve, characterized in that a decoupling member is arranged to decouple the latch when being moved in proximal direction (P) nearly into a maximum proximal position, thus allowing the retraction sleeve to move in distal direction (D) and retract the needle, wherein the aperture is arranged to allow a respective decoupling arm of the decoupling member to be flexed outward, and wherein a gap is provided between a front face of the retraction sleeve and a syringe holder in their respective maximum proximal positions, wherein the syringe is arranged for joint axial movement with the syringe holder, wherein the gap is arranged to allow the retraction sleeve to travel a distance before retracting the syringe holder so the syringe holder is retracted after the decoupling arms met the apertures.

2. Auto-injector according to claim 1, characterized in that the viscous fluid is silicone grease.

3. Auto-injector according to claims 1, characterized in that a circumferential shoulder is arranged between two portions of at least one of the inner wall and the outer wall with the two portions having different cross sections in a manner to have the cavity sealed by the respective collar only until the collar reaches the shoulder and rendering the cavity untight when the collar has travelled past the shoulder.

4. Auto-injector according to claims 1, characterized in that the driving means are arranged as spring means, wherein activating means are arranged to lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection.

5. Auto-injector according to claim 4, characterized in that the spring means is a single compression spring arranged to be grounded at a distal end in the housing for advancing the needle and for injecting the dose of medicament (M) and wherein the compression spring is arranged to have its ground in the housing switched to its proximal end for retracting the syringe.

6. Auto-injector according to claim 5, characterized in that the compression spring is arranged inside the retraction sleeve with its distal end bearing against a distal end face and with its proximal end bearing against a thrust face of the decoupling member.

7. Auto-injector according to claims 5, characterized in that the decoupling arms have inner ramped surfaces bearing against a first shoulder of the plunger in proximal direction (P), wherein the resilient decoupling arms are supportable by an inner wall of the retraction sleeve in order to prevent the decoupling arms from being flexed outward and slip past the first shoulder and the aperture in the retraction sleeve allows the decoupling arms to be flexed outward by the first shoulder thus allowing the first shoulder to slip through the decoupling arms in proximal direction (P), wherein the plunger is arranged for pushing the syringe and/or the stopper in proximal direction (P).

8. Auto-injector according to claim 7, characterized in that the syringe holder is slidably arranged in the retraction sleeve, wherein the syringe holder is provided with at least two resilient syringe holder arms arranged distally, the syringe holder arms having a respective inclined surface for bearing against a second shoulder , which is arranged at the plunger proximally from the first shoulder wherein the syringe holder arms are supportable by an inner surface of the housing in order to prevent them from being flexed outward and wherein a widened portion is provided in the housing for allowing the syringe holder arms to flex outwards when the syringe holder has nearly reached a maximum proximal position thus allowing the second shoulder to slip through the syringe holder arms and to switch load of the compression spring from the syringe to the stopper.

9. Auto-injector according to claims 6, characterized in that a stud is arranged at the distal end of the plunger , wherein the retraction sleeve has two or more resilient arms distally from the end face for holding the stud, the stud and/or the resilient arms having ramp features so the resilient arms may be pushed apart by the stud when the plunger is moved in proximal direction (P), wherein the activating means comprise a trigger button arranged at the distal end (D) of the auto-injector, the trigger button axially moveable and having at least two rigid retainers for preventing the resilient arms from being flexed outward when the trigger button is in a maximum distal position and wherein, upon pushing the trigger button in proximal direction (P) the retainers are moved in proximal direction (P) in a manner to allow the resilient arms to be flexed out by the stud biased by the compression spring in proximal direction (P) thus allowing the stud to slip past the resilient arms in proximal direction (P).

10. Auto-injector according to claim 9, characterized in that a safety button is arranged laterally at the housing, the safety button having an interlock for preventing the trigger button from being pushed, the safety button arranged to pull the interlock outward when operated thus allowing the trigger button to be pushed.

11. Auto-injector according to claim 3, characterized in that a cap is provided at the proximal end of the housing, wherein a sheet metal clip is attached to the cap for joint axial movement and independent rotation, the sheet metal clip arranged to extend through an orifice into the housing when the cap is attached to the housing , wherein the sheet metal clip comprises at least two barbs snapped into a circumferential notch or behind a shoulder of a protective needle shield attached to the hollow needle.

12. Auto-injector according to claim 11, characterized in that the cap is attachable to the housing by a screw connection.