Low-permeability, laser-activated drug delivery device
First Claim
1. An implantable drug delivery device comprising:
- a first shell element with a first enclosed cavity volume, wherein the first shell element forms a low-permeability barrier, and wherein the first shell element is configured to absorb light irradiation from a laser source, the light irradiation causing a breach in the first shell element;
a first dose of an active pharmaceutical ingredient contained in the first enclosed cavity volume, wherein the first dose of the active pharmaceutical ingredient is released when the first shell element is breached;
a second shell element with a second enclosed cavity volume, wherein the second shell element forms a low-permeability barrier; and
a second dose of the active pharmaceutical ingredient contained in the second enclosed cavity volume, wherein the device releases time-delayed, multiple doses of the active pharmaceutical ingredient from a single laser activation of the first shell element.
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Accused Products
Abstract
An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low-permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.
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Citations
16 Claims
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1. An implantable drug delivery device comprising:
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a first shell element with a first enclosed cavity volume, wherein the first shell element forms a low-permeability barrier, and wherein the first shell element is configured to absorb light irradiation from a laser source, the light irradiation causing a breach in the first shell element; a first dose of an active pharmaceutical ingredient contained in the first enclosed cavity volume, wherein the first dose of the active pharmaceutical ingredient is released when the first shell element is breached; a second shell element with a second enclosed cavity volume, wherein the second shell element forms a low-permeability barrier; and a second dose of the active pharmaceutical ingredient contained in the second enclosed cavity volume, wherein the device releases time-delayed, multiple doses of the active pharmaceutical ingredient from a single laser activation of the first shell element. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An implantable drug delivery device comprising:
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an active pharmaceutical ingredient; a metallic substrate surrounding the active pharmaceutical ingredient forming a low-permeability barrier preventing moisture from entering the active pharmaceutical ingredient; a polymer substrate bonded to the metallic substrate forming an external coating layer on an outer surface of the metallic substrate, wherein the metallic substrate is configured to absorb light irradiation from a laser source, the light irradiation causing a breach in the polymer and metallic substrates, and wherein the active pharmaceutical ingredient is released when the polymer and metallic substrates are breached.
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Specification