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Method, device, and system to control pH in pulmonary tissue of a subject

  • US 8,911,711 B2
  • Filed: 09/30/2008
  • Issued: 12/16/2014
  • Est. Priority Date: 09/30/2008
  • Status: Expired due to Fees
First Claim
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1. A method for modulating pH of a virus-infected pulmonary tissue in a mammalian or avian subject to treat a pulmonary viral infectious disease comprising:

  • generating an aerosol dose of the pharmaceutical composition from an aerosol generator to contact the virus-infected pulmonary tissue in the subject with a pharmaceutical composition including at least one agent, wherein the pharmaceutical composition includes a membrane selective for the charged ion and is configured to achieve a selected pH of the pulmonary tissue, wherein the membrane selective for the charged ion includes liposome membranes of two or more distinct and non-overlapping particle size ranges configured to contact two or more levels of the pulmonary tissue, wherein a first particle size of the two or more distinct and non-overlapping particle size ranges contacts an upper airway passage of the pulmonary tissue in the subject and a second particle size of the two or more distinct and non-overlapping particle size ranges contacts a lower airway passage of the pulmonary tissue in the subject, andoperably coupling the aerosol generator to at least one of a heating, ventilation, or air conditioning system to allow delivery of the aerosol dose of the pharmaceutical composition through the system.

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