Collagen carrier of therapeutic genetic material and method

• US 8,911,763 B2
• Filed: 10/30/2007
• Issued: 12/16/2014
• Est. Priority Date: 10/10/1997
• Status: Expired due to Term

• Current Assignee: ED. Geistlich Soehne AG Fuer Chemische Industrie
• Original Assignee: ED. Geistlich Soehne AG Fuer Chemische Industrie
• Inventors: Geistlich, Peter, Schloesser, Lothar
• Primary Examiner(s): Noble, Marcia S
• Application Number:
  US11/928,384
• Publication Number:
  US 20080107710A1
• Time in Patent Office: 2,604 Days
• Field of Search: 623/1.47, 424/425, 514/44.R
• US Class Current: 424/425
• CPC Class Codes: A61B 17/00234 for minimally invasive surgery A61B17/0218, A61B17/0469, A61B17/12013, A61B17/1285, A61B17/29, A61B17/320016 take precedence
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/06166 Sutures suture materials A61L17/00; manufacture of artificial threads D01D; treatment of threads D06M
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2/30767 Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
• CPC Class Codes: A61F 2002/0086 for preferentially controlling or promoting the growth of specific types of cells or tissues
• CPC Class Codes: A61F 2002/009 for hindering or preventing attachment of biological tissue
• CPC Class Codes: A61F 2002/2817 Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/30761 Support means for artificial cartilage, e.g. cartilage defect covering membranes
• CPC Class Codes: A61F 2002/3093 for promoting ingrowth of bone tissue
• CPC Class Codes: A61F 2002/30932 for retarding or preventing ingrowth of bone tissue
• CPC Class Codes: A61F 2002/30971 Laminates, i.e. layered products
• CPC Class Codes: A61F 2002/4635 using minimally invasive surgery
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2240/001 Designing or manufacturing processes
• CPC Class Codes: A61F 2310/00365 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61F 2310/00982 : Coating made of collagen
• CPC Class Codes: A61K 38/1875 : Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
• CPC Class Codes: A61K 48/0075 : characterised by an aspect of the delivery route, e.g. oral, subcutaneous
• CPC Class Codes: A61K 9/0024 : Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/7023 : Transdermal patches and similar drug-containing composite devices, e.g. cataplasms galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006
• CPC Class Codes: A61L 15/325 : Collagen
• CPC Class Codes: A61L 15/40 : containing ingredients of undetermined constitution or reaction products thereof , e.g. plant or animal extracts
• CPC Class Codes: A61L 2300/258 : Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
• CPC Class Codes: A61L 2300/414 : Growth factors
• CPC Class Codes: A61L 2430/06 : for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 27/20 : Polysaccharides
• CPC Class Codes: A61L 27/24 : Collagen
• CPC Class Codes: A61L 27/36 : containing ingredients of undetermined constitution or reaction products thereof , e.g. transplant tissue, natural bone, extracellular matrix isolated natural compounds, e.g. collagen A61L27/24
• CPC Class Codes: A61L 27/3847 : Bones
• CPC Class Codes: A61L 27/3852 : Cartilage, e.g. meniscus
• CPC Class Codes: A61L 27/54 : Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 31/005 : Ingredients of undetermined constitution or reaction products thereof
• CPC Class Codes: A61L 31/044 : Collagen
• CPC Class Codes: A61L 31/14 : Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/16 : Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C08L 5/00 : Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
• CPC Class Codes: C08L 5/08 : Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Abstract

A collagen matrix material is charged with a cell growth-promoting derived nucleic acid sequence. The nucleic acid sequence-charged collagen matrix material may be utilized in a method of promoting regeneration of surface cartilage of a joint. In the method, an area of injury is covered with the nucleic acid sequence-charged collagen matrix material, the collagen matrix material is fixed over the area to be treated, and the area is allowed to heal.

Claims

1. A nucleic acid carrier collagen material consisting of a membrane sheet having a thickness of about 0.2-2 mm, wherein said membrane sheet is formed from natural animal membrane comprising native insoluble collagen I, collagen III or a mixture thereof, wherein said membrane sheet carries a nucleic acid sequence encoding a protein that promotes cell growth, wherein said membrane sheet includes a barrier layer which acts as a barrier to inhibit passage of cells therethrough, wherein said barrier layer has a smooth face so as to inhibit cell adhesion thereon, and wherein said barrier layer further has a fibrous face opposite said smooth face.

2. The collagen material of claim 1, wherein said membrane is formed from peritoneum, and has a thickness of about 0.2-0.7 mm.

3. The collagen material of claim 1 wherein said nucleic acid sequence is purified from its natural cellular environment.

4. The collagen material of claim 1 wherein said nucleic acid sequence is a gene.

5. The collagen material of claim 1 wherein said nucleic acid sequence is DNA.

6. The collagen material of claim 1 wherein said protein promotes cartilage growth.

7. The collagen material of claim 1 wherein said protein promotes bone growth.

8. A method of promoting regeneration of surface cartilage of a joint, comprising covering an area of damaged cartilage of a joint with a collagen material according to claim 1;

fixing said collagen material over said area; and

allowing said area to regenerate cartilage.

9. A method of repairing injury or damage to bone, cartilage or a combination thereof, comprising covering an area of injured or damaged bone, cartilage or a combination thereof with a collagen material according to claim 1;

fixing said collagen material over said area; and

allowing said area to heal.

10. The method of claim 9 wherein said area is a dental area, maxilofacial area or spinal area.

11. The method of claim 9 further comprising, prior to covering said area, removing a cartilage defect from said area.

12. The method of claim 9, further comprising, prior to said covering, making a plurality of punctures to a subchondral plate of said area.