Dry powder inhaler and system for drug delivery
First Claim
1. Fumaryl diketopiperazine (FDKP) microparticles comprising a trans-FDKP isomer content of about 45% to about 63%.
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Accused Products
Abstract
A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.
508 Citations
21 Claims
- 1. Fumaryl diketopiperazine (FDKP) microparticles comprising a trans-FDKP isomer content of about 45% to about 63%.
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12. FDKP microparticles having improved aerodynamic performance that have been prepared by a process comprising:
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determining the trans-FDKP isomer content; wherein the microparticles have a trans-FDKP isomer content of about 45% to about 65%. - View Dependent Claims (13, 14)
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- 15. An FDKP composition comprising a trans isomer content of about 45% to about 56%.
Specification