PPAR-sparing thiazolidinedione salts for the treatment of metabolic diseases

• US 8,912,335 B2
• Filed: 12/15/2010
• Issued: 12/16/2014
• Est. Priority Date: 12/15/2009
• Status: Active Grant

• Current Assignee: Cirius Therapeutics, Inc.
• Original Assignee: Metabolic Solutions Development Company, LLC
• Inventors: Colca, Gerard R., Tanis, Steven P., Larsen, Scott D.
• Primary Examiner(s): Morris, Patricia L
• Application Number:
  US13/515,508
• Publication Number:
  US 20120309975A1
• Time in Patent Office: 1,462 Days
• Field of Search: 546/269.7
• US Class Current: 546/269.7
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 5/00 Drugs for disorders of the endocrine system
• CPC Class Codes: C07D 277/34 Oxygen atoms
• CPC Class Codes: C07D 417/12 linked by a chain containing hetero atoms as chain links

Abstract

The present invention relates to novel salts of thiazolidinediones and other pharmaceutical agents that are useful for treating and/or preventing metabolic diseases (e.g., diabetes, or neurodegenerative diseases (e.g., Alzheimer'"'"'s Disease).

Claims

1. A sodium salt of a compound having the structure: