System and method to localize changes in intrathoracic fluid content using measured impedance in an implantable device

• US 8,914,101 B2
• Filed: 10/30/2008
• Issued: 12/16/2014
• Est. Priority Date: 10/30/2008
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Hettrick, Douglas A., Sarkar, Shantanu, Zielinksi, Todd M., Knox, Kevin P.
• Primary Examiner(s): Hoekstra, Jeffrey G
• Assistant Examiner(s): Stout, Michael C
• Application Number:
  US12/261,131
• Publication Number:
  US 20100113962A1
• Time in Patent Office: 2,238 Days
• Field of Search: 600/547, 600/382
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/4878 Evaluating oedema

Abstract

An implantable medical device and associated methods monitor thoracic fluid status and discriminate thoracic fluid conditions. Intrathoracic impedance is measured along multiple intrathoracic measurement vectors using implanted electrodes. A map of thoracic conductivity is computed using the measured intrathoracic impedances. A thoracic fluid condition is detected in response to the computed map.

Claims

1. A method of detecting a thoracic fluid condition in an implantable medical device system, comprising:

periodically measuring intrathoracic impedance for one of a plurality of intrathoracic measurement vectors using a pair of a plurality of electrodes implanted along the thoracic cavity of a patient, the one of the plurality of intrathoracic measurement vectors selected as representative of a global intrathoracic impedance of the patient, wherein the global intrathoracic impedance is sensitive to an intrathoracic impedance change with low specificity as to a location of the intrathoracic impedance change;

detecting, based on the periodic measurements, the intrathoracic impedance change for the one of the plurality of intrathoracic measurement vectors representative of the global intrathoracic impedance of the patient, wherein the intrathoracic impedance change is a trigger for intrathoracic impedance measurements for the plurality of intrathoracic measurement vectors;

in response to detecting the intrathoracic impedance change, measuring intrathoracic impedance for the plurality of intrathoracic measurement vectors using the plurality of electrodes;

in response to measuring the intrathoracic impedances, computing a conductivity of each of a plurality of intrathoracic impedance mapping locations corresponding to the plurality of intrathoracic measurement vectors, wherein each of a plurality of anatomic regions is associated with a respective one or more of the mapping locations;

detecting a change in conductivity for one or more of the mapping locations based on the computed conductivities of the mapping locations;

detecting the thoracic fluid condition in response to the detected change in conductivity; and

discriminating, by a processor, within which one or more of the plurality of anatomic regions the thoracic fluid condition occurred based upon for which of the mapping locations the change in conductivity was detected.

2. The method of claim 1 wherein detecting the change in the computed conductivity comprises:

determining a baseline conductivity for each of the plurality of mapping locations;

computing a cumulative sum of differences between the computed conductivity and the baseline conductivity over time for each of the plurality of mapping locations; and

comparing each of the cumulative sums to a conductivity change threshold.

3. The method of claim 1 wherein discriminating the detected thoracic fluid condition comprises applying detection criteria to a group of the mapping locations which collectively define a first anatomic region of the plurality of anatomic regions.

4. The method of claim 3 wherein discriminating the detected thoracic fluid condition further comprises:

applying detection criteria to a second group of the mapping locations which collectively define a second anatomic region of the plurality of anatomic regions different than the first anatomic region; and

detecting a global thoracic condition when both the first and the second anatomic regions are affected.

5. The method of claim 1 wherein discriminating within which one or more of the plurality of anatomic regions the thoracic fluid condition occurred comprises discriminating within which one or more of a heart region, a lung region, and an implantable medical device pocket region the thoracic fluid condition occurred based upon for which of the mapping locations the change in conductivity was detected.

6. The method of claim 1 wherein discriminating within which one or more of the plurality of anatomic regions the thoracic fluid condition occurred comprises discriminating within which one or more of a left posterior region, a right posterior region, a left anterior region, and a right anterior region the thoracic fluid condition occurred based upon for which of the mapping locations the change in conductivity was detected.

14. The method of claim 1, further comprising creating a plurality of isopotential lines with an excitation current from an electrode pair, wherein each of the intrathoracic impedance mapping locations correspond to a respective intersection between the isopotential lines and measurement vectors.

15. The method of claim 14, wherein the intrathoracic impedance mapping locations create a two dimensional grid of computed conductivities within the thoracic cavity of the patient.

16. The method of claim 1, wherein the thoracic fluid condition comprises pulmonary edema.

17. The method of claim 1, wherein the thoracic fluid condition comprises cardiac dilation.

18. The method of claim 1, wherein the thoracic fluid condition comprises acute anemia.

19. The method of claim 1, wherein the thoracic fluid condition comprises an implanted device pocket infection.

20. The method of claim 1, wherein the plurality of electrodes are carried by at least one of a subcutaneously implanted medical device or one or more subcutaneously implanted leads coupled to the implanted medical device, the subcutaneously implanted medical device and the one or more subcutaneously implanted leads being implanted outside of a ribcage of the patient.

7. An implantable medical device, comprising;

a plurality of electrodes configured to be implanted along the thoracic cavity of a patient;

an impedance measuring module configured to periodically measure intrathoracic impedance for one of a plurality of intrathoracic measurement vectors using a pair of the plurality of electrodes implanted along the thoracic cavity of the patient, the one of the plurality of intrathoracic measurement vectors selected as representative of a global intrathoracic impedance of the patient, wherein the global intrathoracic impedance is sensitive to an intrathoracic impedance change with low specificity as to a location of the intrathoracic impedance change;

a processor configured to detect, based on the periodic measurements, the intrathoracic impedance change for the one of the plurality of intrathoracic measurement vectors representative of the global intrathoracic impedance of the patient, wherein the intrathoracic impedance change is a trigger for intrathoracic impedance measurements for the plurality of intrathoracic measurement vectors, and wherein the impedance measuring module is configured to, in response to the detection of the intrathoracic impedance change, measure intrathoracic impedance for the plurality of intrathoracic measurement vectors between the plurality of electrodes; and

a mapping module configured to, in response to the intrathoracic impedances being measured, compute a conductivity of each of a plurality of intrathoracic impedance mapping locations corresponding to the plurality of intrathoracic impedance measurement vectors, wherein each of a plurality of anatomic regions is associated with a respective one or more of the mapping locations, wherein

the processor is configured to detect a change in conductivity for one or more of the mapping locations based on the computed conductivities of the mapping locations, detect a thoracic fluid condition in response to the change in conductivity being detected, and discriminate within which one or more of the plurality of anatomic regions the thoracic fluid condition occurred based upon for which of the mapping locations the change in conductivity was detected.

8. The device of claim 7 wherein the processor is configured to, for detection of the change in the computed conductivity, determine a baseline conductivity for each of the plurality of mapping locations, compute a cumulative sum of differences between the computed conductivity and the baseline conductivity over time for each of the plurality of mapping locations, and compare each of the cumulative sums to a conductivity change threshold.

9. The device of claim 7 wherein the processor is configured to apply detection criteria to a group of the mapping locations which collectively define a first anatomic region of the plurality of anatomic regions to discriminate the detected thoracic fluid condition.

10. The device of claim 9 wherein, for discriminating the detected thoracic fluid condition, the processor is configured to:

apply detection criteria to a second group of the mapping locations which collectively define a second anatomic region of the plurality of anatomic regions different than the first anatomic region; and

detect a global thoracic condition when both the first and the second anatomic regions are affected.

11. The device of claim 7 wherein the processor is configured to discriminate within which one or more of a heart region, a lung region, and an implantable medical device pocket region the thoracic fluid condition occurred based upon for which of the mapping locations the change in conductivity was detected.

12. The device of claim 7 wherein the processor is configured to discriminate within which one or more of a left posterior region, a right posterior region, a left anterior region, and a right anterior region the thoracic fluid condition occurred based upon for which of the mapping locations the change in conductivity was detected.

13. A system for detecting a thoracic fluid condition in an implantable medical device, comprising:

means for periodically measuring intrathoracic impedance for one of a plurality of intrathoracic measurement vectors using a pair of a plurality of electrodes implanted along the thoracic cavity of a patient, the one of the plurality of intrathoracic measurement vectors selected as representative of a global intrathoracic impedance of the patient, wherein the global intrathoracic impedance is sensitive to an intrathoracic impedance change with low specificity as to a location of the intrathoracic impedance change;

means for detecting, based on the periodic measurements, the intrathoracic impedance change for the one of the plurality of intrathoracic measurement vectors representative of the global intrathoracic impedance of the patient, wherein the intrathoracic impedance change is a trigger for intrathoracic impedance measurements for the plurality of intrathoracic measurement vectors;

means for, in response to detecting the intrathoracic impedance change, measuring intrathoracic impedance for the plurality of intrathoracic measurement vectors;

means for, in response to measuring the intrathoracic impedances, computing a conductivity of each of a plurality of intrathoracic impedance mapping locations corresponding to the plurality of intrathoracic measurement vectors, wherein each of a plurality of anatomic regions is associated with a respective one or more of the mapping locations;

means for detecting a change in conductivity for one or more of the mapping locations based on the computed conductivities of the mapping locations;

means for detecting the thoracic fluid condition in response to the detected change in conductivity; and

means for discriminating within which one or more of the plurality of anatomic regions the thoracic fluid condition occurred based upon for which of the mapping locations the change in conductivity was detected.