Method for hemodynamic optimization using plethysmography
First Claim
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1. A system, comprising:
- at least one implantable lead comprising at least one electrode;
at least one pulse generator coupleable to the at least one lead and configured to deliver cardiac stimulation to pacing sites adjacent the at least one electrode;
at least one sensing circuit configured to obtaining a signal indicative of electrical activity of the patient'"'"'s heart;
at least one plethysmograph sensor configured to obtain a plethysmograph signal indicative of changes in arterial blood volume; and
at least one processor for use in selecting a pacing site at which to deliver cardiac stimulation to a patient;
wherein for each of a plurality of pacing sites and/or combination of pacing sites within the patient, the system is configured to use the at least one lead, the at least one pulse generator, the at least one sensing circuit, and the at least one processor, todeliver cardiac stimulation using the pacing site or the combination of pacing sites;
obtain the signal indicative of electrical activity of the patient'"'"'s heart while the pacing site or the combination of pacing sites is being used to deliver cardiac stimulation;
obtain the plethysmograph signal indicative of changes in arterial blood volume while the pacing site or the combination of pacing sites is being used to deliver cardiac stimulation; and
determine a time delay between a predetermined feature of the signal indicative of electrical activity and a predetermined feature of the plethysmograph signal indicative of changes in arterial blood volume; and
wherein the system is also configured to select a pacing site or a combination of pacing sites, from the plurality of pacing sites, based on the time delays.
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Abstract
Time delays between a feature of a signal indicative of electrical activity of a patient'"'"'s heart and a feature of a plethysmograph signal indicative of changes in arterial blood volume are used to arrange the operation of an implantable device, such as a pacemaker. Shorter time delays between the feature of the signal indicative of electrical activity of a patient'"'"'s heart and the feature of the plethysmograph signal indicative of changes in arterial blood volume are indicative of larger cardiac stroke volumes. The time delay can be used to select a pacing site or combination of pacing sites and/or to select a pacing interval set.
30 Citations
14 Claims
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1. A system, comprising:
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at least one implantable lead comprising at least one electrode; at least one pulse generator coupleable to the at least one lead and configured to deliver cardiac stimulation to pacing sites adjacent the at least one electrode; at least one sensing circuit configured to obtaining a signal indicative of electrical activity of the patient'"'"'s heart; at least one plethysmograph sensor configured to obtain a plethysmograph signal indicative of changes in arterial blood volume; and at least one processor for use in selecting a pacing site at which to deliver cardiac stimulation to a patient; wherein for each of a plurality of pacing sites and/or combination of pacing sites within the patient, the system is configured to use the at least one lead, the at least one pulse generator, the at least one sensing circuit, and the at least one processor, to deliver cardiac stimulation using the pacing site or the combination of pacing sites; obtain the signal indicative of electrical activity of the patient'"'"'s heart while the pacing site or the combination of pacing sites is being used to deliver cardiac stimulation; obtain the plethysmograph signal indicative of changes in arterial blood volume while the pacing site or the combination of pacing sites is being used to deliver cardiac stimulation; and determine a time delay between a predetermined feature of the signal indicative of electrical activity and a predetermined feature of the plethysmograph signal indicative of changes in arterial blood volume; and wherein the system is also configured to select a pacing site or a combination of pacing sites, from the plurality of pacing sites, based on the time delays. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A system, comprising:
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at least one implantable lead comprising at least one electrode; at least one pulse generator coupleable to the at least one lead and configured to deliver cardiac stimulation to pacing sites adjacent the at least one electrode; at least one sensing circuit configured to obtaining a signal indicative of electrical activity of the patient'"'"'s heart; at least one plethysmograph sensor configured to obtain a plethysmograph signal indicative of changes in arterial blood volume; at least one processor for use in selecting a pacing interval parameter set to deliver cardiac stimulation to a patient; wherein for each of a plurality of pacing interval parameter sets, the system is configured to use the at least one lead, the at least one pulse generator, the at least one sensing circuit, and the at least one processor, to deliver cardiac stimulation using the pacing interval parameter set; obtain the signal indicative of electrical activity of the patient'"'"'s heart while the pacing interval parameter set is being used to deliver cardiac stimulation; obtain the plethysmograph signal indicative of changes in arterial blood volume while the pacing interval parameter set is being used to deliver cardiac stimulation; and determine a time delay between a predetermined feature of the signal indicative of electrical activity and a predetermined feature of the plethysmograph signal indicative of changes in arterial blood volume; and wherein the system is also configured to select a pacing interval parameter set, from the plurality of pacing interval parameter sets, based on the time delays. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14)
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Specification