Nose stimulator for producing a stimulation signal to a nose

• US 8,914,116 B2
• Filed: 06/18/2009
• Issued: 12/16/2014
• Est. Priority Date: 06/18/2008
• Status: Expired due to Fees

• Current Assignee: NasoPhlex B.V.
• Original Assignee: NasoPhlex B.V.
• Inventors: De Vos, Gerrit Johannis
• Primary Examiner(s): Heller, Tammie K
• Application Number:
  US13/000,336
• Publication Number:
  US 20110313481A1
• Time in Patent Office: 2,007 Days
• Field of Search: 607/42, 607/135, 607/140
• US Class Current: 607/45
• CPC Class Codes: A61B 5/4076 Diagnosing or monitoring particular conditions of the nervous system A61B5/4821, A61B5/4824 take precedence
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61B 5/7217 of noise originating from a therapeutic or surgical apparatus, e.g. from a pacemaker
• CPC Class Codes: A61B 7/003 Detecting lung or respiration noise
• CPC Class Codes: A61H 2201/1604 Head
• CPC Class Codes: A61H 2201/1607 Holding means therefor
• CPC Class Codes: A61H 2201/165 Wearable interfaces
• CPC Class Codes: A61H 2205/022 Face
• CPC Class Codes: A61H 2205/023 Nose
• CPC Class Codes: A61H 2230/06 Heartbeat rate
• CPC Class Codes: A61H 2230/40 Respiratory characteristics
• CPC Class Codes: A61H 39/002 Using electric currents electrotherapy A61N1/32
• CPC Class Codes: A61N 1/0546 Nasal electrodes
• CPC Class Codes: A61N 1/3601 of respiratory organs

Abstract

An electronic stimulation system has a casing; electronics inside the casing a first detector arranged to sense whether a human being is breathing or not, a stimulation device arranged to receive a control signal from said electronics and to provide stimuli to a nasal philtre or a human nasopharynx. The electronics generate the control signal in dependence on the breathing signal and the system has a holding device for attaching the stimulation device to the nose.

Claims

1. An electronic stimulation system arranged to be worn in or on a human nose comprising:

a casing;

a first detection device arranged to sense at least breathing activity from a human being and to generate a detection signal accordingly,

electronics arranged within said casing and comprising a controller connected to said first detection device and arranged to process said detection signal and to generate a control signal when said controller has determined that said human being is in a state of developing apnoea;

a stimulation device arranged to receive said control signal from said electronics and to provide electrical stimuli;

wherein said electronic stimulation system comprises a holding device arranged to attach at least the stimulation device to the nose, the holding device comprising either a nose cap having a form of a human nose and made of a flexible material or a nose plug made of a flexible material and designed to adapt to the form of a human nostril, and said electronic stimulation system being either arranged such that, when worn in or on said human nose, said stimulation device is pressed against a predetermined portion of the nasal philtre in order to provide said electrical stimuli to said predetermined portion of said nasal philtre or arranged to comprise a wire connected to said electronics in order to provide said electrical stimuli to a human nasopharynx, the stimulation device being arranged to generate a plurality of stimulation signals upon receiving said control signal from said electronics during a plurality of stimulation times T_stim, a first stimulation time only starting after a first waiting time after said electronics have established that said human has a high risk of developing apnoea, consecutive stimulation times being separated by a second waiting time, a consecutive stimulation time starting after said second waiting time, if the electronics have established that breathing has not started as a result of stimulation signals in a preceding stimulation time, wherein the first and second waiting times may be different and the stimulation signals having an average repetition frequency of 1 to 100 Hz, such as to provoke an induced aspiration reflex by a resuscitating stimulation of the respiratory area of the human brain stem, the first and second waiting time being between 0 and 10 seconds and the stimulation time being between 0 and 10 seconds.

2. The electronic stimulation system according to claim 1, wherein the casing is designed as said nose plug to be inserted in a nostril, the casing comprising said detection device and said stimulation device, the system comprising one of a thread, a wire and a fibre extending from the casing and arranged to stimulate a nasopharyngeal area.

3. The electronic stimulation system according to claim 2, wherein said casing is connected to one of a brace and bracket to clamp said casing in said nostril when said system is in use.

4. The electronic stimulation system according to claim 1, wherein the system comprises a second detection device arranged to sense a heartbeat of the human being, to generate a heartbeat signal to that effect and to transmit said heartbeat signal to said electronics, the electronics being arranged to generate said control signal in dependence on said heartbeat signal too.

5. The electronic stimulation system according to claim 4, wherein said second detection device is arranged to sense the heartbeat in at least one of a human carotid, vein and artery.

6. The electronic stimulation system according to claim 4, wherein said second detection device is arranged to generate the heartbeat signal from a portion of a human body in, on or near the nose.

7. The electronic system according to claim 1, wherein the system comprises a second detection device arranged to sense electrical signals from the brain of the human being and to generate an electro encephalogram (EEG) signal from the electrical signals, the electronics being arranged to generate said control signal also in dependence on said electro encephalogram signal.

8. The electronic stimulation system according to claim 1, wherein the first detection device is arranged to sense airflow caused by breathing through the nose or the mouth.

9. The electronic stimulation system according to claim 1, wherein said casing is made from a flexible material, selected from a series of flexible materials including silicone.

10. The electronic stimulation system according to claim 1, wherein the electronic stimulation system comprises a plurality of stimulation units arranged in a two dimensional matrix form.

11. The electronic stimulation system according to claim 10, wherein the stimulation units are either arranged as at least one of electrical stimulation units and mechanical stimulation units.

12. The electronic system according to claim 1, wherein the plurality of stimulation signals each have a form of one of a plurality of pulses, a plurality of triangular signals, a plurality of sinusoidal signals, a plurality of block signals.

13. The electronic system according to claim 1, wherein at least one of the first waiting time, the second waiting time and stimulation time is variable.

14. The electronic system according to claim 1, wherein the system comprises a sensor to measure oxygen saturation in the blood of the subject within a nostril.

15. The electronic system according to claim 1, wherein the waiting time is between 0 and 5 seconds.

16. The electronic system according to claim 1, wherein the waiting time is between 0.5 and 2 seconds.

17. The electronic system according to claim 1, wherein the stimulation time is between 0 and 5 seconds.

18. The electronic system according to claim 1, wherein the stimulation time is between 0.5 and 2 seconds.

19. A method of providing stimuli to a human body comprising;

providing an electronic stimulation system comprising a casing, a detection device, electronics arranged within said casing and comprising a controller connected to said detection device, a stimulation device, and a holding device arranged to attach at least the stimulation device to a nose of said human body, the holding device comprising either a nose cap having a form of a human nose and made of a flexible material or a nose plug made of a flexible material and designed to adapt to the form of a human nostril,

by said detection device, detecting at least breathing activity from a human being and generating a detection signal accordingly,

by said controller, processing said detection signal and generating a control signal when said human being is in a state of developing apnoea;

by said stimulation device, receiving said control signal and providing stimuli to at least one of a predetermined portion of a nasal philtre and a human nasopharynx;

by said stimulation device, providing said stimuli to at least one of the nasal philtre and the human nasopharynx, generating a plurality of stimulation signals upon receiving said control signal from said electronics during a plurality of stimulation times T_stim, a first stimulation time only starting after a first waiting time after said controller has established that said human has a high risk of developing apnoea, consecutive stimulation times being separated by a second waiting time, a consecutive stimulation time starting after said second waiting time if said electronics have established that breathing has not started as a result of stimulation signals in a preceding stimulation time, wherein the first and second waiting times may be different and the stimulation signals have an average repetition frequency of 1 to 100 Hz, such as to provoke an induced aspiration reflex by a resuscitating stimulation of the respiratory area of the human brain stem, the first and second waiting time being between 0 and 10 seconds and the stimulation time being between 0 and 10 seconds.