System and method to evaluate cardiovascular health

• US 8,915,860 B2
• Filed: 11/04/2010
• Issued: 12/23/2014
• Est. Priority Date: 05/05/2009
• Status: Active Grant

• Current Assignee: Robert P. Blankfield
• Original Assignee: Robert P. Blankfield
• Inventors: Blankfield, Robert P.
• Primary Examiner(s): Gedeon, Brian T
• Assistant Examiner(s): TEJANI, ANKIT D
• Application Number:
  US13/642,921
• Publication Number:
  US 20130237875A1
• Time in Patent Office: 1,510 Days
• Field of Search: None
• US Class Current: 600/526
• CPC Class Codes: A61B 5/02 Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
• CPC Class Codes: A61B 5/02035 Determining blood viscosity
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/03 Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs A61B5/205 takes precedence
• CPC Class Codes: A61B 5/107 Measuring physical dimensions, e.g. size of the entire body or parts thereof
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/4848 Monitoring or testing the effects of treatment, e.g. of medication
• CPC Class Codes: A61B 5/7225 Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation A61B5/30, A61B5/316 take precedence; transformers for specific applications H01F38/00; amplifiers H03F
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence

Abstract

Systems and methods are described herein to evaluate a candidate medication as it relates to a subject'"'"'s cardiovascular health. A processing component is employed to measure a first value of one or more cardiovascular markers, via a computer, which are associated with a circulatory system of each subject that is to receive the candidate medication. The candidate medication is administered to each subject and a second value of one or more cardiovascular markers are measured subsequent to the administration as of the candidate medication. Continued testing of the candidate medication can be continued dependent upon the change in the one or more cardiovascular markers.

Claims

1. A system to evaluate safety of a medication, comprising:

an evaluation component adapted to measure a first cardiovascular marker associated with a circulatory system of a subject and a second cardiovascular marker associated with the circulatory system of the subject to determine a fluid retention value based at least in part upon the cardiovascular markers received, wherein the first cardiovascular marker is measured before the medication is administered to the subject and wherein the second cardiovascular marker is measured after the medication is administered, and wherein the first and second cardiovascular markers include at least one cardiovascular marker selected from the group consisting of stroke volume of the circulatory system of the subject, mass of blood per heart stroke of the subject, a volume of blood within the circulatory system of the subject, a plasma volume within the circulatory system of the subject, a turbulence of blood flow within the circulatory system of the subject, a velocity of blood flow within the circulatory system of the subject, a fluid retention measurement associated with the circulatory system of the subject, an intravascular volume of the circulatory system of the subject, a degree of leg edema of the subject, a body weight of the subject, a body mass of the subject, a nutriuretic peptide level of the subject, a blood pressure of the subject, a pressure at which the blood is ejected from the heart of the subject, a cardiac work of the subject, a cardiac output of the subject, viscosity of blood within the circulatory system of the subject, serum osmolality within the circulatory system of the subject, density of blood within the circulatory system of the subject, Reynolds number associated with the circulatory system of the subject;

a memory store adapted to store the first and second cardiovascular markers from the subject, the memory store also receives subject information selected from the group consisting of age, gender, heredity, blood pressure, serum cholesterol level, lipoprotein level, tobacco use, subject weight, a biomarker, and glucose intolerance;

wherein the evaluation component is in communication with the memory store and a reporting component, the evaluation component determines a fluid retention threshold based on at least the subject information, the evaluation component also evaluates the cardiovascular health of the subject by comparing the fluid retention value to the fluid retention threshold, and wherein if the fluid retention value is greater than the fluid retention threshold, the evaluation component provides an evaluation to the reporting component containing a recommendation to discontinue use of the medication;

wherein the first cardiovascular marker and second cardiovascular marker includes a calculation of a Reynolds number, wherein the evaluation component calculates the Reynolds number using at least one of cardiac output, intravascular volume, blood pressure, blood flow, mass of the blood, mass of the blood per stroke, density of the blood, volume of the blood, plasma volume, stroke volume, viscosity of the blood, serum osmolality, velocity of the blood, and turbulence of the blood of the subject.

2. A system to evaluate safety of a medication, comprising:

an evaluation component adapted to measure a first cardiovascular marker associated with a circulatory system of a subject and a second cardiovascular marker associated with the circulatory system of the subject to determine a fluid retention value based at least in part upon the cardiovascular markers received, wherein the first cardiovascular marker is measured before the medication is administered to the subject and wherein the second cardiovascular marker is measured after the medication is administered, and wherein the first and second cardiovascular markers include at least one cardiovascular marker selected from the group consisting of stroke volume of the circulatory system of the subject, mass of blood per heart stroke of the subject, a volume of blood within the circulatory system of the subject, a plasma volume within the circulatory system of the subject, a turbulence of blood flow within the circulatory system of the subject, a velocity of blood flow within the circulatory system of the subject, a fluid retention measurement associated with the circulatory system of the subject, an intravascular volume of the circulate system of the subject, a degree of leg edema of the subject, a body weight of the subject, a body mass of the subject, a nutriuretic peptide level of the subject, a blood pressure of the subject, a pressure at which the blood is ejected from the heart of the subject, a cardiac work of the subject, a cardiac output of the subject, viscosity of blood within the circulatory system of the subject, serum osmolality within the circulatory system of the subject, density of blood within the circulatory system of the subject, Reynolds number associated with the circulatory system of the subject;

a memory store adapted to store the first and second cardiovascular markers from the subject, the memory store also receives subject information selected from the group consisting of age, gender, heredity, blood pressure, serum cholesterol level, lipoprotein level, tobacco use, subject weight, a biomarker, and glucose intolerance;

wherein the evaluation component is in communication with the memory store and a reporting component, the evaluation component determines a fluid retention threshold based on at least the subject information, the evaluation component also evaluates the cardiovascular health of the subject by comparing the fluid retention value to the fluid retention threshold, and wherein if the fluid retention value is greater than the fluid retention threshold, the evaluation component provides an evaluation to the reporting component containing a recommendation to discontinue use of the medication;

wherein the evaluation component determines the difference between the fluid retention threshold and fluid retention value as a fluid retention percentage, and wherein the system further includes a medication selection component in communication with the evaluation component to receive the fluid retention percentage from the evaluation component, the medication selection component includes a first tier of 0-4%, a second tier of 5-9%, a third tier of 10-14% and a fourth tier of 15-20%, the medication selection component being adapted to recommend an alternative medication from a plurality of alternative medications based on the tier in which the fluid retention percentage falls and communicate the alternative medication recommendation to the reporting component.

3. The system of claim 2, wherein the first and second cardiovascular marker is a stroke volume.