In vivo device and method for researching GI tract processes, microbes, and variables associated with illnesses and diseases
First Claim
1. An interactive research device for at least one of perturbing, measuring and dispensing substances along an intestinal tract of a user, the device comprising:
- a capsule configured to be swallowed and passed through the intestinal tract, the capsule including;
a housing defining an opening adapted to allow the substances to pass into and out of the housing,at least one sensor transducer,at least one belt disposed within the housing and defining a plurality of indentations, each of the indentations having a volume configured to perform at least one of collecting and dispensing the samples of matter, and at least one of a motor and an accuator disposed within the housing.
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Accused Products
Abstract
An interactive research device comprised of an orally ingested capsule with pockets rendering the capsule capable of sampling intestinal tracts (gut) substances and microbes before, during and after delivery of system perturbation substances and methods of use and associate system are described. Sensors are provided to simultaneously measure, monitor, record, and transmit data in real time obtained from within the exact vicinity of substance deployment and location of microbial assisted digestive processes. In vivo collected samples are also collected and preserved for in vitro analysis. Digestive processes and dysfunctions involving proteins that result in “gluten sensitivities” and dozens of gut-based diseases that develop in stages, and have been mysteries for over 2,000 years, can be analyzed. The capabilities were developed to permit research within the heretofore inaccessible and important regions of the small intestine where villi functions are compromised, and in the upper colon. Special focus includes determining roles microbes and their byproduct substances in cascade play in autoimmune system responses and diseases.
46 Citations
20 Claims
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1. An interactive research device for at least one of perturbing, measuring and dispensing substances along an intestinal tract of a user, the device comprising:
a capsule configured to be swallowed and passed through the intestinal tract, the capsule including; a housing defining an opening adapted to allow the substances to pass into and out of the housing, at least one sensor transducer, at least one belt disposed within the housing and defining a plurality of indentations, each of the indentations having a volume configured to perform at least one of collecting and dispensing the samples of matter, and at least one of a motor and an accuator disposed within the housing. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. An interactive research method for perturbing and measuring responses along an intestinal tract of a user, the method comprising:
providing a capsule configured to be swallowed and passed through the intestinal tract, the capsule including; a housing defining an opening adapted to allow samples of matter to pass into and out of the housing, at least one sensor transducer, a belt disposed within the housing and defining a plurality of indentations, each of the indentations having a volume configured to collect or dispense the samples of matter, and a motor or actuator disposed within the housing, inserting the capsule into the intestinal tract, and continuously monitoring and reacting to the responses. - View Dependent Claims (18, 19)
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20. A research system comprising a capsule configured to be swallowed and passed through the intestinal tract, the capsule including:
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a housing defining an opening adapted to allow samples of matter to pass into and out of the housing, at least one sensor transducer, a belt disposed within the housing and defining a plurality of indentations, each of the indentations having a volume configured to collect or dispense the samples of matter, and an extra-body telemetry for processing data and generating a 3-dimensional image using the data.
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Specification