Device and method for destruction of cancer cells
First Claim
Patent Images
1. A system for non-thermal tissue ablation, comprising:
- a tissue treatment probe having one or more elongate electrodes shaped for positioning or advancement within a target tissue region comprising cancerous cells; and
an energy source coupled to the probe and configured to cause the probe to apply an alternating electrical field of less than 50 V/cm to the target tissue region to non-thermally destroy cancerous cells of the target tissue region; and
a control system operatively connected to the energy source and the probe, the control system comprising;
one or more processors; and
memory, including instructions stored thereon that, when executed by the one or more processors, cause the control system to at least provide, via the one or more elongate electrodes when positioned in target tissue, the alternating electrical field through the target tissue region so as to non-thermally destroy the cancerous cells of the target tissue region around the electrodes, the electrical field comprising a frequency between about 50 kHz to about 300 kHz.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention provides devices and systems, as well as methods, of electric field delivery and non-thermal or selective ablation of target tissue regions, including selective ablation of cancerous cells and solid tumors. A method of the present invention includes delivering an electric field to a tissue, including positioning an electrode within a target tissue region comprising cancerous cells, and applying an alternating electrical current to the target tissue so as to non-thermally ablate cancerous cells of the target tissue region around the electrodes.
-
Citations
27 Claims
-
1. A system for non-thermal tissue ablation, comprising:
-
a tissue treatment probe having one or more elongate electrodes shaped for positioning or advancement within a target tissue region comprising cancerous cells; and an energy source coupled to the probe and configured to cause the probe to apply an alternating electrical field of less than 50 V/cm to the target tissue region to non-thermally destroy cancerous cells of the target tissue region; and a control system operatively connected to the energy source and the probe, the control system comprising; one or more processors; and memory, including instructions stored thereon that, when executed by the one or more processors, cause the control system to at least provide, via the one or more elongate electrodes when positioned in target tissue, the alternating electrical field through the target tissue region so as to non-thermally destroy the cancerous cells of the target tissue region around the electrodes, the electrical field comprising a frequency between about 50 kHz to about 300 kHz. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
-
-
9. A system for selectively destroying cancerous cells, comprising:
-
a plurality of elongate, tissue penetrating electrodes positionable within a target tissue, the plurality comprising a first electrode and one or more secondary electrodes, a treatment volume at least partially definable by the secondary electrodes, with the first electrode positionable within the treatment volume; an energy source coupled to the plurality of elongate electrodes to provide one or more alternating electric fields of less than 50 V/cm extending radially from the first electrode and through the treatment volume; and a control system operatively connected to the energy source, the control system comprising; one or more processors; and memory, including instructions stored thereon that, when executed by the one or more processors, cause the control system to at least apply the one or more alternating electric fields to the treatment volume, where the electrodes are positioned such that the treatment volume is at least partially defined by the secondary electrodes, so as to preferentially destroy the cancerous cells compared to non-cancerous cells within the treatment volume. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
-
Specification