Portable rapid diagnostic test reader

• US 8,916,390 B2
• Filed: 05/31/2012
• Issued: 12/23/2014
• Est. Priority Date: 02/06/2012
• Status: Active Grant

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Ozcan, Aydogan, Mudanyali, Onur, Dimitrov, Stoyan, Sikora, Uzair, Padmanabhan, Swati, Navrus, Isa
• Primary Examiner(s): Chin, Chris L
• Assistant Examiner(s): MOERSCHELL, RICHARD P
• Application Number:
  US13/485,689
• Publication Number:
  US 20130203043A1
• Time in Patent Office: 936 Days
• Field of Search: None
• US Class Current: 436/518
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: G01N 2021/0118 Apparatus with remote processing
• CPC Class Codes: G01N 2021/558 Measuring reflectivity and transmission
• CPC Class Codes: G01N 2021/7786 Fluorescence
• CPC Class Codes: G01N 2021/825 Agglutination
• CPC Class Codes: G01N 2021/8488 the band presenting reference patches
• CPC Class Codes: G01N 21/01 Arrangements or apparatus for facilitating the optical investigation
• CPC Class Codes: G01N 21/645 Specially adapted constructive features of fluorimeters
• CPC Class Codes: G01N 21/8483 Investigating reagent band test-element handling not specific to a test method G01N33/4875; analytical elements specific to chemical analysis of biological material G01N33/52; autometer with reagent band G01N35/04
• CPC Class Codes: G01N 2201/0221 Portable; cableless; compact; hand-held
• CPC Class Codes: G01N 2201/062 LED's
• CPC Class Codes: G01N 2201/0634 Diffuse illumination
• CPC Class Codes: G01N 33/543 with an insoluble carrier for immobilising immunochemicals
• CPC Class Codes: G01N 33/56905 Protozoa
• CPC Class Codes: G01N 33/5695 Mycobacteria
• CPC Class Codes: G01N 33/56988 HIV or HTLV
• CPC Class Codes: G06F 16/245 Query processing
• CPC Class Codes: G06K 7/10732 Light sources
• CPC Class Codes: G06K 7/10831 Arrangement of optical elements, e.g. lenses, mirrors, prisms optical elements per se G02B
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

A portable rapid diagnostic test reader system includes a mobile phone having a camera and one or more processors contained within the mobile phone and a modular housing configured to mount to the mobile phone. The modular housing including a receptacle configured to receive a sample tray holding a rapid diagnostic test. At least one illumination source is disposed in the modular housing and located on one side of the rapid diagnostic test. An optical demagnifier is disposed in the modular housing interposed between the rapid diagnostic test and the mobile phone camera.

Claims

1. A portable rapid diagnostic test reader system comprising:

a mobile phone having a camera and one or more processors contained within the mobile phone, the mobile phone containing imaging software thereon executable by the one or more processors;

a modular housing configured to mount to the mobile phone, the modular housing including a receptacle configured to receive a rapid diagnostic test or a sample tray holding a rapid diagnostic test, the rapid diagnostic test comprising a test location and a control location;

at least one illumination source disposed in the modular housing and located on one side of the rapid diagnostic test;

an optical demagnifier disposed in the modular housing, the optical demagnifier demagnifying the image of the rapid diagnostic test to place the test location and control location in a field of view of the mobile phone camera; and

wherein the imaging software extracts regions of interest from the test location and the control location in an image of the field of view and compares respective regions of interest with respective threshold values and characterizes the rapid diagnostic test.

2. The portable rapid diagnostic test reader system of claim 1, wherein the optical demagnifier comprises free space, a lens or multiple lenses.

3. The portable rapid diagnostic test reader system of claim 1, wherein the at least one illumination source transmits illumination through the rapid diagnostic test and onto the camera of the mobile phone.

4. The portable rapid diagnostic test reader system of claim 1, wherein the at least one illumination source reflects illumination off the rapid diagnostic test and onto the mobile phone camera.

5. The portable rapid diagnostic test reader system of claim 1, wherein the at least one illumination source comprises an array of individual illumination sources.

6. The portable rapid diagnostic test reader system of claim 1, wherein the rapid diagnostic test comprises a fluorescent test, and the at least one illumination source emits illumination at a wavelength that causes the rapid diagnostic test to fluoresce.

7. The portable rapid diagnostic test reader system of claim 1, further comprising a removable color filter interposed between the camera of the mobile phone and the rapid diagnostic test.

8. The portable rapid diagnostic test reader system of claim 1 further comprising:

a second illumination source disposed in the modular housing and located at a second, opposing side of the rapid diagnostic test; and

a switch to selectively illuminate the rapid diagnostic test with either the first illumination source or the second illumination source.

9. The portable rapid diagnostic test reader system of claim 1, further comprising a plurality of sample trays, wherein each of the plurality of sample trays is configured to a particular rapid diagnostic test.

10. The portable rapid diagnostic test reader system of claim 1, wherein the first illumination source comprises an array of individual illumination sources disposed on a side of the rapid diagnostic test opposite the mobile phone.

11. The portable rapid diagnostic test reader system of claim 8, wherein the second illumination source comprises first and second arrays of individual illumination sources disposed on a side of the rapid diagnostic test nearest the mobile phone, the first and second arrays of individual illumination sources configured to reflect illumination from the rapid diagnostic test and onto the mobile phone camera.

12. The portable rapid diagnostic test reader system of claim 1, further comprising a power source disposed in the housing.

13. The portable rapid diagnostic test reader system of claim 8, wherein the first and second illumination sources are powered by a power source of the mobile phone.

14. The portable rapid diagnostic test reader system of claim 8, wherein the switch is connected to an audio jack of the mobile phone.

15. The portable rapid diagnostic test reader system of claim 8, further comprising a visual indicator configured to indicate proper loading of the sample tray holding a rapid diagnostic test within the housing.

16. The portable rapid diagnostic test reader system of claim 1, wherein the at least one light source emits illumination at a wavelength range that causes the rapid diagnostic test to fluoresce.

17. The portable rapid diagnostic test reader system of claim 1, wherein the sample tray comprises a sample tray configured to hold multiple different types of rapid diagnostic tests.

18. The portable rapid diagnostic test reader system of claim 1, wherein the rapid diagnostic test comprises one of a strip, dipstick, cassette, card, and pad.

19. The portable rapid diagnostic test reader system of claim 8, wherein at least one of the first illumination source and the second illumination source comprises a tunable wavelength.

23. The portable rapid diagnostic test reader system of claim 1, wherein the characterization of the rapid diagnostic test reader comprises data corresponding to the quantification of a response, detection, or sensing level.

24. The portable rapid diagnostic test reader system of claim 1, wherein the characterization of the rapid diagnostic test reader comprises data corresponding to a positive/negative evaluation.

20. A portable rapid diagnostic test reader system comprising:

a mobile phone having a camera and one or more processors contained within the mobile phone, the mobile phone containing imaging software thereon executable by the one or more processors;

a modular housing configured to mount to the mobile phone, the modular housing including a receptacle configured to receive a rapid diagnostic test, the rapid diagnostic test comprising a test location and a control location;

a first illumination source disposed in the modular housing and configured to transmit illumination through the rapid diagnostic test and onto the camera in a transmission mode;

a second illumination source disposed in the modular housing and configured to reflect illumination off the rapid diagnostic test and onto the camera in a reflection mode

a switch for actuating the first illumination source and the second illumination source; and

wherein the imaging software extracts regions of interest from the test location and the control location in an image of the field of view and compares respective regions of interest with respective threshold values and characterizes the rapid diagnostic test.

21. The portable rapid diagnostic test reader system of claim 20, wherein the characterization of the rapid diagnostic test reader comprises data corresponding to the quantification of a response, detection, or sensing level.

22. The portable rapid diagnostic test reader system of claim 20, wherein the characterization of the rapid diagnostic test reader comprises data corresponding to a positive/negative evaluation.