Quinazoline derivatives for the treatment of viral infections and further diseases

• US 8,916,575 B2
• Filed: 05/18/2012
• Issued: 12/23/2014
• Est. Priority Date: 05/18/2011
• Status: Active Grant

• Current Assignee: Janssen Sciences Ireland UC (Johnson & Johnson)
• Original Assignee: Janssen R&D Ireland (Johnson & Johnson)
• Inventors: McGowan, David, Raboisson, Pierre Jean-Marie Bernard, Jonckers, Tim Hugo Maria, Last, Stefaan Julien, Embrechts, Werner, Pieters, Serge Maria Aloysius
• Primary Examiner(s): Ward, Paul V.
• Application Number:
  US14/118,527
• Publication Number:
  US 20140073642A1
• Time in Patent Office: 949 Days
• Field of Search: 544/283, 544/284, 514/266.1, 514/266.2
• US Class Current: 514/266.2
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 239/95 with hetero atoms directly attached in positions 2 and 4
• CPC Class Codes: C07D 295/192 from aromatic carboxylic acids
• CPC Class Codes: C07D 401/06 linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 403/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 491/056 with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Abstract

This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll-like-receptors is involved.

Claims

1. A compound of formula (I)

2. A compound of formula (I) according to claim 1 wherein R₅ is hydrogen or fluorine.

3. A compound of claim 1 selected from the group consisting of

4. A compound of claim 1 having the structure:

5. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients, diluents or carriers.