Resistive anti-obesity devices

• US 8,920,358 B2
• Filed: 08/04/2010
• Issued: 12/30/2014
• Est. Priority Date: 01/19/2005
• Status: Expired due to Fees

• Current Assignee: GI Dynamics Incorporated
• Original Assignee: GI Dynamics Incorporated
• Inventors: Levine, Andy H., Lamport, Ronald B., Melanson, David A., Randle, Stuart A.
• Primary Examiner(s): Dornbusch, Dianne
• Application Number:
  US12/850,185
• Publication Number:
  US 20100298632A1
• Time in Patent Office: 1,609 Days
• Field of Search: 606/153, 606/213, 606/151, 606/191, 623/23.64, 623/23.65, 623/23.68, 623/23.7, 623/2.1, 623 211- 219, 600/32, 600/37, 128/830, 128/831, 128/898, 604/8, 604/9
• US Class Current: 604/9
• CPC Class Codes: A61F 2002/044 Oesophagi or esophagi or gullets
• CPC Class Codes: A61F 5/0079 Pyloric or esophageal obstructions

Abstract

A patient is provided with an increased sense of satiety by increasing resistance to the outflow of food from the stomach and through the intestines. Stomach emptying may be slowed with devices implantable within the gastrointestinal tract below the stomach. Implants are preferably removable and can include artificial strictures that may be adjustable to vary the rate of stomach emptying. Slowing gastric emptying may induce satiety for a longer period and may therefore reduce food consumption. Many of the embodiments include intestinal liners or sleeves, but they need not. The resistor concept may be applied to a simple anchor and resistor without a long liner.

Claims

1. A gastrointestinal implant comprising:

an anchor configured for implantation within a gastrointestinal tract of an animal at a position distal to the animal'"'"'s pylorus;

a collapsible, elongated liner coupled to the anchor, the liner formed from a substantially non-permeable material, the anchor and liner defining a lumen through which chyme passes, the liner being thin and unsupported beyond the anchor and tending to collapse upon itself when empty; and

an orifice in communication with the anchor, the orifice retained at between 3 mm and 5 mm in diameter, the orifice being a hole in a membrane positioned within and across the lumen, the anchor removably securing the liner and membrane in position and the membrane retarding the outflow of chyme from the stomach.

2. The gastrointestinal implant of claim 1, wherein the orifice is adjustable to selectively vary resistance provided to the outflow of chyme from the stomach.

3. The gastrointestinal implant of claim 1, wherein the liner has a non-uniform diameter along its axis.

4. The gastrointestinal implant of claim 3, wherein the liner includes an axial length having a reduced diameter that is bounded on either end by an adjacent portion of liner having a greater diameter.

5. The gastrointestinal implant of claim 1, wherein the liner material reduces effectiveness of peristaltic forces.

6. The gastrointestinal implant of claim 1, wherein the anchor comprises a radial spring adapted to sealably engage tissue of the gastrointestinal tract.

7. The gastrointestinal implant of claim 1, wherein the anchor comprises at least one barb adapted for insertion into muscular tissue of the gastrointestinal tract.

8. The implant of claim 1, wherein the membrane is elastomeric.

9. The implant of claim 1, wherein the membrane comprises plastically deformable material.

10. The implant of claim 1, wherein the anchor is self-expanding and has a relaxed diameter of at least 40 mm.

11. The implant of claim 1, wherein the anchor is self-expanding and has a relaxed diameter of at least 45 mm.

12. The implant of claim 11, wherein the anchor is a wave anchor.

13. The gastrointestinal implant of claim 1, comprising plural holes in the membrane.

14. A gastrointestinal implant comprising:

an anchor configured for implantation within a gastrointestinal tract of an animal at a position distal to the animal'"'"'s pylorus;

a collapsible, elongated liner coupled to the anchor, the liner formed from a substantially non-permeable material, the anchor and liner defining a lumen through which chyme passes, the liner being thin and unsupported beyond the anchor and tending to collapse upon itself when empty; and

an orifice in communication with the anchor, the orifice retained at less than 10 millimeters in diameter, the orifice being a hole in a membrane positioned within and across the lumen, the anchor removably securing the liner and membrane in position and the membrane retarding the outflow of chyme from the stomach, the membrane being elastomeric and the orifice being able to temporarily expand under pressure from the chyme.

15. The implant of claim 14, wherein the orifice is between 3 mm and 5 mm in diameter.

16. The implant of claim 14, wherein the anchor is self-expanding and has a relaxed diameter of at least 40 mm.

17. The implant of claim 14, wherein the anchor is self-expanding and has a relaxed diameter of at least 45 mm.

18. The implant of claim 17, wherein the anchor is a wave anchor.

19. The gastrointestinal implant of claim 14, comprising plural holes in the membrane.

20. The gastrointestinal implant of claim 14, wherein the liner has a non-uniform diameter along its axis.

21. The gastrointestinal implant of claim 20, wherein the liner includes an axial length having a reduced diameter that is bounded on either end by an adjacent portion of liner having a greater diameter.

22. The gastrointestinal implant of claim 14, wherein the anchor comprises a radial spring adapted to sealably engage tissue of the gastrointestinal tract.

23. The gastrointestinal implant of claim 14, wherein the anchor comprises at least one barb adapted for insertion into muscular tissue of the gastrointestinal tract.

24. A gastrointestinal implant comprising:

an anchor configured for implantation within a gastrointestinal tract of an animal at a position at or distal to the animal'"'"'s pylorus;

a collapsible, elongated liner coupled to and removably secured by the anchor, the liner formed a substantially non-permeable material, the anchor and liner defining a lumen through which chyme passes, the liner being thin and unsupported beyond the anchor and tending to collapse upon itself when empty; and

a diaphragm having plural orifices and being positioned within and across the lumen to provide partial blockage.

25. The gastrointestinal implant of claim 24, wherein the diaphragm is formed from a membrane and the plural orifices comprise plural orifices in the membrane.

26. The gastrointestinal implant of claim 24, wherein each of the plural orifices is less than 10 mm in diameter.

27. The gastrointestinal implant of claim 24, wherein each of the plural orifices is 5 mm in diameter or less.

28. The gastrointestinal implant of claim 24, wherein each of the plural orifices is 3 mm in diameter or less.

29. The gastrointestinal implant of claim 24, wherein the diaphragm includes a screen and the plural orifices comprise plural orifices in the screen.

30. The gastrointestinal implant of claim 24, wherein the plural orifices comprise plastically deformable material.

31. The gastrointestinal implant of claim 24, wherein the liner includes an axial length having a reduced diameter that is bounded on either end by an adjacent portion of liner having a greater diameter.

32. The gastrointestinal implant of claim 24, wherein the anchor comprises a radial spring adapted to sealably engage tissue of the gastrointestinal tract.

33. The gastrointestinal implant of claim 24, wherein the anchor comprises at least one barb adapted for insertion into muscular tissue of the gastrointestinal tract.

34. The gastrointestinal implant of claim 24, wherein the anchor is self-expanding and has a relaxed diameter of at least 40 mm.

35. The gastrointestinal implant of claim 34, wherein the anchor comprises a wave anchor.