Electrochemical method of making porous particles using a constant current density

• US 8,920,625 B2
• Filed: 04/28/2008
• Issued: 12/30/2014
• Est. Priority Date: 04/27/2007
• Status: Active Grant

• Current Assignee: Ohio State Innovation Foundation (Ohio State University), Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: The Ohio State University Research Foundation, Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Ferrari, Mauro, Liu, Xuewu, Cheng, Ming-Cheng
• Primary Examiner(s): Gakh, Yelena G
• Application Number:
  US12/110,515
• Publication Number:
  US 20080280140A1
• Time in Patent Office: 2,437 Days
• US Class Current: 205/640
• CPC Class Codes: A61K 8/25 Silicon; Compounds thereof
• CPC Class Codes: A61K 9/141 Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers (co) spray-dried products A61K9/16, (co) lyophilised products A61K9/19; the carrier being chemically bound to the active ingredient A61K47/50
• CPC Class Codes: C01B 33/02 Silicon forming single crystals or homogeneous polycrystalline material with defined structure C30B
• CPC Class Codes: C01B 33/021 Preparation chemical coating from the vapour phase C23C16/00
• CPC Class Codes: C01P 2006/16 Pore diameter
• CPC Class Codes: C25F 3/12 of semiconducting materials
• CPC Class Codes: Y10T 428/2982 Particulate matter [e.g., sphere, flake, etc.]

Abstract

Provided is a particle that includes a first porous region and a second porous region that differs from the first porous region. Also provided is a particle that has a wet etched porous region and that does have a nucleation layer associated with wet etching. Methods of making porous particles are also provided.

Claims

1. A method of making porous particles comprising:

providing a substrate having a surface;

forming a first nanoporous layer in the substrate by electrochemical etching using a constant current density;

continuing the etching by increasing the current density to form in the substrate a release layer, below the first nanoporous layer, having a porosity larger than that of the first nanoporous layer by electrochemical etching;

depositing a protective layer onto the substrate;

patterning the protective layer;

wherein the patterning of the protective layer determines the lateral shape of the porous particles;

etching the unprotected substrate to form pillars under the protective layer;

removing the remaining protective layer; and

releasing the one or more particles from the substrate,

wherein the releasing comprises breaking the second porous layer and wherein the released one or more particles contain at least a portion of the first porous layer.

2. The method of claim 1, wherein the substrate is a silicon substrate.

3. The method of claim 1, wherein the substrate is a silicon substrate and the electrochemical etching comprises exposing the substrate to a solution comprising HF.

4. The method of claim 3, wherein the solution further comprises at least one of water or ethanol.

5. The method of claim 1, further comprising preventing a formation of a nucleation layer associated with said electrochemical etching by using an initial current density high enough to prevent formation of the nucleation layer.

6. The method of claim 1, wherein the method further comprises continuing the etching cycles to repeat the steps of forming the first nanoporous and the second porous layers at least once.

7. The method of claim 1, wherein said patterning of protective layer is performed lithographically.

8. The method of claim 1, wherein a largest dimension of an individual particle of the one or more particles, is no more than 5 microns.

9. The method of claim 1, further chemically modifying a surface of the one or more particles.

10. The method of claim 9, wherein said chemically modifying is performed prior to said releasing.

11. The method of claim 10, wherein said chemically modifying modifies a surface of an individual particle of the one or more particles asymmetrically.

12. The method of claim 11, wherein said chemically modifying comprises filling at least a portion of pores of the first porous layer with a sacrificial material.

13. The method of claim 9, wherein the chemically modifying comprises at least one of silanizing, oxidizing and antibody conjugating.

14. The method of claim 1, wherein an individual particle of the one or more released particle further comprises a second nanoporous region, that differs from the first nanoporous region in at least one property selected from the group consisting of a pore density, a pore size, a pore shape, a pore charge, a pore surface chemistry, and a pore orientation.

15. The method of claim 1, wherein said forming the first nanoporous layer comprises tuning at least one parameter of the first nanoporous layer selected from a thickness, a pore size, porosity, pore orientation and pore shape.

16. The method of claim 15, wherein said tuning comprises at least one of selecting a material composition of the substrate, selecting a resistivity of the substrate, selecting a crystal orientation of the substrate, selecting etching current, selecting chemical composition of etching solution, selecting etching concentration, and selecting etching time.

17. The method of claim 1, wherein said releasing comprises exposing the substrate to an ultrasound.

18. A method of making periodic stack structures of porous particles comprising:

providing a substrate having a surface;

depositing a first protective layer on the surface of the substrate;

patterning a resistant layer onto the first protective layer;

wherein the patterning determines the lateral shape of the particles;

removing the first protective layer from areas not covered by the resistant layer pattern;

deep etching the unpatterned areas of the substrate to form trenches resulting in formation of pillars under the protective layer;

depositing a second protective layer over the pillars and the trenches;

exposing the top of the pillars by removing portions of the second protective layer;

forming a first nanoporous layer in the pillar by electrochemical etching using a constant current density;

continuing the etching by increasing the current density to form in the pillar a release layer, below the first porous layer, having a porosity larger than that of the first nanoporous layer;

continuing the etching cycle to repeat the steps of forming the first nanoporous and the second porous layers at least once; and

releasing the patterned one or more stack(s) of particles from the substrate,

wherein the releasing comprises removing the second protective layer from the sides of the pillars and breaking the release layer and wherein the released one or more particles contain at least a portion of the first porous layer.

19. The method of claim 18, wherein the substrate is a silicon substrate.

20. The method of claim 18, wherein the patterning is performed lithographically.

21. The method of claim 18, wherein the deep etching is by deep reactive ion etching.

22. The method of claim 18, wherein the protective layer is a silicon nitride film or a silicon dioxide film.

23. The method of claim 18, wherein the electrochemical etching comprises exposing the substrate to a solution comprising HF and at least one of water or ethanol.

24. The method of claim 18, wherein an individual particle of the one or more released particle further comprises a second nanoporous region, that differs from the first nanoporous region in at least one property selected from the group consisting of a pore density, a pore size, a pore shape, a pore charge, a pore surface chemistry, and a pore orientation.

25. A method of making porous particles comprising:

providing a substrate having a surface;

depositing a protective layer onto the surface of the substrate;

patterning the protective layer onto the substrate;

wherein the patterning of the protective layer determines the lateral shape of the porous particles;

etching the unprotected substrate to form a nanoporous layer by electrochemical etching using a constant current density;

continuing the etching by increasing the current density to form in the substrate a release layer, below the first porous layer, having a porosity larger than that of the first porous layer; and

releasing the patterned one or more particles from the substrate, wherein the releasing comprises removing the remaining protective layer and breaking the release layer and wherein the released one or more particles contain at least a portion of the first porous layer.

26. The method of claim 25, further comprising etching a trench in the areas of the substrate not protected by the protective layer prior to formation of the first nanoporous layer.