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Devices and systems for creation of DNA cluster arrays

  • US 8,921,073 B2
  • Filed: 06/22/2007
  • Issued: 12/30/2014
  • Est. Priority Date: 06/23/2006
  • Status: Active Grant
First Claim
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1. A system for creation of samples in a flow cell, the system comprising:

  • a system chassis and a flow cell placement area that is supported by the system chassis, the placement area being configured to receive the flow cell;

    at least one manifold having a manifold body configured to be placed onto the flow cell;

    at least one reagent reservoir;

    at least one temperature control component; and

    at least one computer control component;

    wherein the reagent reservoir, the manifold, the temperature control component, and the computer control component are functionally connected to one another;

    wherein the reagent reservoir and the manifold are capable of being directly or indirectly fluidly connected to one another when connected to said flow cell;

    wherein the reagent reservoir, the manifold body, and the flow cell are arranged such that one or more fluids are capable of flow under control of the computer control component from the reagent reservoir, through the manifold body, and into said flow cell, allowing creation of the sample;

    wherein the manifold body includes a manifold port that is configured to removably engage a flow cell port of the flow cell to fluidly connect the reagent reservoir to the flow cell, the manifold body configured to move with respect to the placement area to removably engage the manifold port and flow cell port; and

    wherein the system further comprises a flow cell holder that is configured to move between open and closed positions to permit access to the flow cell placement area for placing the flow cell on the flow cell placement area and for placing the manifold body onto the flow cell, the manifold body configured to move with respect to the flow cell holder when the flow cell holder is stationary in the open position, the flow cell holder pressing the manifold body against the flow cell when in the closed position so that the manifold body presses the flow cell toward the flow cell placement area.

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