Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
First Claim
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1. A method for preparing a crystalline salt of a compound of Formula (II)
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Abstract
The invention relates to crystalline peptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. This invention also relates to methods for the preparation of amino acid keto-epoxides. Specifically, allylic ketones are stereoselectively converted to the desired keto epoxides.
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15 Claims
- 1. A method for preparing a crystalline salt of a compound of Formula (II)
- 11. A crystalline salt of a compound having a structure of Formula (II)
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