Antiviral compounds

• US 8,921,341 B2
• Filed: 10/08/2013
• Issued: 12/30/2014
• Est. Priority Date: 11/16/2011
• Status: Active Grant

• Current Assignee: Gilead Sciences Inc.
• Original Assignee: Gilead Pharmasset LLC (Gilead Sciences Inc.)
• Inventors: Bacon, Elizabeth M., Cottell, Jeromy J., Katana, Ashley Anne, Kato, Darryl, Krygowski, Evan S., Link, John O., Taylor, James, Tran, Chinh Viet, Trejo Martin, Teresa Alejandra, Yang, Zheng-Yu, Zipfel, Sheila
• Primary Examiner(s): Lundgren, Jeffrey S.
• Assistant Examiner(s): SIMMONS, CHRIS E
• Application Number:
  US14/049,133
• Publication Number:
  US 20140112885A1
• Time in Patent Office: 448 Days
• Field of Search: 514/894, 514/741, 514/453, 548/571
• US Class Current: 514/92
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/4188 condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
• CPC Class Codes: A61K 31/7056 containing five-membered rings with nitrogen as a ring hetero atom
• CPC Class Codes: A61K 31/7064 containing condensed or non-condensed pyrimidines
• CPC Class Codes: A61K 31/7072 having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
• CPC Class Codes: A61K 38/06 Tripeptides
• CPC Class Codes: A61K 38/07 Tetrapeptides
• CPC Class Codes: A61K 38/21 Interferons [IFN]
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/60 the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• CPC Class Codes: A61P 1/16 for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 31/14 for RNA viruses
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 405/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 491/052 the oxygen-containing ring being six-membered
• CPC Class Codes: C07F 5/025 Boronic and borinic acid compounds

Abstract

The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Claims

1. A compound of the formula:

2. A pharmaceutical composition comprising a compound of the formula:

3. The pharmaceutical composition of claim 2, further comprising an inhibitor of hepatitis C virus NS5B polymerase.

4. A method of treating hepatitis C virus in a human patient in need thereof, said method comprising administering to the human patient a pharmaceutical composition comprising a therapeutically effective amount of the compound of the formula:

5. The method of claim 4, further comprising administering an inhibitor of hepatitis C virus NS5B polymerase.

6. The method of claim 5, further comprising administering an interferon or pegylated interferon to the patient.

7. The method of claim 5, further comprising administering ribavirin to the patient.