Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample

• US 8,922,781 B2
• Filed: 11/29/2005
• Issued: 12/30/2014
• Est. Priority Date: 11/29/2004
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Tearney, Guillermo J., de Boer, Johannes F., Bouma, Brett Eugene
• Primary Examiner(s): Chowdhury, Tarifur
• Assistant Examiner(s): Cook, Jonathon
• Application Number:
  US11/288,994
• Publication Number:
  US 20060114473A1
• Time in Patent Office: 3,318 Days
• Field of Search: 356479-497, 385/12
• US Class Current: 356/479
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: G01B 9/02001 characterised by controlling or generating intrinsic radiation properties
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence
• CPC Class Codes: G02B 21/0032 Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers G02B21/0036 - G02B21/008; means for illumination of specimens in general G02B21/06
• CPC Class Codes: G02B 21/0056 based on optical coherence, e.g. phase-contrast arrangements, interference arrangements
• CPC Class Codes: G02B 23/2453 of the proximal end
• CPC Class Codes: G02B 23/2469 using optical fibres
• CPC Class Codes: G02B 23/26 using light guides for illumination G02B23/2469

Abstract

Devices, arrangements, endoscopes, catheters and methods adapted to propagate at least one electro-magnetic radiation are provided. In particular, a waveguide apparatus specifically configured may be utilized to split the electro-magnetic radiation into a plurality of beams that are intended to illuminate a biological sample, and impart a unique associated characteristic unto each of the beams. The beams may be intended to illuminate a biological sample at distinct locations, and impart a unique associated characteristic unto each of the beams. In addition, a control apparatus may be provided which is configured to control at least one of the fibers and which can be input to the fibers so as to modify the unique associated characteristics of the beams being propagated along the fibers, and thereby modify the characteristics of the distinct locations on the sample.

Claims

1. An arrangement adapted to propagate at least one electro-magnetic radiation, comprising:

a waveguide apparatus which includes a structure that is specifically configured to split the at least one electro-magnetic radiation into a plurality of beams that are intended to illuminate a biological sample, and impart at least one unique associated characteristic unto each of the beams, wherein, in a direction of the at least one electro-magnetic radiation, the waveguide apparatus has at least one two-dimensional flat surface.

2. The arrangement according to claim 1, wherein the waveguide apparatus includes a mirror tunnel.

3. The arrangement according to claim 1, further comprising:

a first illumination arrangement that receives the at least one electro-magnetic radiation, and produces a first radiation at least one of (i) within or (ii) in a close proximity to the waveguide apparatus based on the at least one electro-magnetic radiation; and

a second illumination arrangement that receives at least one second radiation based on the first radiation.

4. The arrangement according to claim 3, wherein the at least one second radiation is an approximation of the first radiation.

5. The arrangement according to claim 3, wherein the first illumination arrangement includes an optical fiber.

6. The arrangement according to claim 5, wherein the first illumination arrangement further includes a lens.

7. The arrangement according to claim 3, further comprising a further apparatus which is configured to alter the waveguide apparatus so as to modify the unique associated characteristics of the beams during the use of the waveguide apparatus.

8. The arrangement according to claim 7, wherein the unique associated characteristics include at least one of path-lengths or phases of the respective beams.

9. The arrangement according to claim 7, wherein the further apparatus controls the waveguide apparatus by modifying structural characteristics of the waveguide apparatus during the use of the waveguide apparatus.

10. The arrangement according to claim 9, wherein the further apparatus generates the modification of the structural characteristics of the waveguide apparatus that is dynamically asymmetric with respect to a cross-section of the waveguide apparatus.

11. The arrangement according to claim 10, wherein the second illumination arrangement includes a further illumination arrangement which is configured to arrange the second radiation in a predetermined pattern on the sample.

12. The arrangement according to claim 11, wherein the predetermined pattern is approximately circular.

13. The arrangement according to claim 7, wherein the further apparatus controls the waveguide apparatus by dynamically modifying optical characteristics of the waveguide apparatus.

14. The arrangement according to claim 13, wherein the optical characteristics includes a refractive index.

15. The arrangement according to claim 3, wherein third radiations reflected from the sample are transmitted back through the waveguide apparatus, and are based on the at least one second radiation.

16. The arrangement according to claim 15, further comprising:

a reference arm section structured to propagate a portion of the at least one electro-magnetic radiation to a reference.

17. The arrangement according to claim 16, further comprising:

a first apparatus which combines the third radiation and a fourth radiation returned which relate to the portion of the at least one electro-magnetic radiation from the reference arm to produce an interference radiation;

a second apparatus which is configured to detect the interference radiation; and

a third apparatus which is configured to generate data corresponding to the third radiations returning from the distinct locations on the sample based on the interference radiation.

18. The arrangement according to claim 17, wherein the third apparatus is further configured to generate an image of at least one portion of the sample based on the data.

19. The arrangement according to claim 3, further comprising a radiation receiving arrangement which is adapted to receive third radiations reflected from the sample which are based on the at least one second radiation.

20. The arrangement according to claim 3, wherein the at least one electro-magnetic radiation is generated by a narrowband light source that has a tunable center wavelength.

21. The arrangement according to claim 3, wherein the at least one electro-magnetic radiation is generated by a broadband light source, and wherein a third radiation reflected from the sample that is associated with the second radiation and a further radiation returned from the reference arm section are adapted to interfere with one another and be received by a spectrometer apparatus.

22. The arrangement according to claim 1, further comprising a probe which houses the waveguide apparatus.

23. The arrangement according to claim 22, wherein the probe is at least one of a catheter, an endoscope or a laparoscope.

24. The arrangement according to claim 1, wherein the arrangement is at least one of a probe, an endoscope or a catheter.

25. The arrangement according to claim 1, wherein, in the direction of the at least one electro-magnetic radiation, all surface of the waveguide apparatus have two-dimensional flat surfaces.

26. The arrangement according to claim 1, wherein the splitter structure includes a grating.

28. The arrangement according to claim 1, wherein the waveguide apparatus includes at least one fiber which is structured to propagate the beams toward the sample.

27. A method for propagating at least one electro-magnetic radiation, comprising:

using a structure of a waveguide apparatus, separating the at least one electro-magnetic radiation into a plurality of beams that are intended to illuminate a biological sample using a waveguide apparatus, and

using the waveguide apparatus, imparting at least one unique associated characteristic unto each of the beams, wherein, in a direction of the at least one electro-magnetic radiation, the waveguide apparatus has at least one two-dimensional flat surface.

29. An arrangement adapted to propagate at least one electro-magnetic radiation, comprising:

a waveguide apparatus which includes a first structure that is specifically configured to separate the at least one electro-magnetic radiation into a plurality of beams, wherein each of the beams illuminates a biological sample at a distinct location,

wherein the illumination of each of the distinct locations is based on a respective unique associated characteristic of a respective one of the beams that impacts such one distinct location, wherein the respective one of the unique associated characteristics is at least one of (i) a path-length, (iii) a radius of curvature, or (ii) a spatial K-vector.

30. The arrangement according to claim 29, further comprising:

a reference arm that receives a first radiation; and

an interferometer that produces a second radiation based on an interference between the beams and the first radiation; and

an electronic arrangement which is configured to determine a reflectance from the different locations based on the second radiation.