Device and method for determining analyte levels

• US 8,923,947 B2
• Filed: 07/23/2013
• Issued: 12/30/2014
• Est. Priority Date: 03/04/1997
• Status: Expired due to Fees

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Shults, Mark C., Updike, Stuart J., Rhodes, Rathbun K., Gilligan, Barbara J., Tapsak, Mark A.
• Primary Examiner(s): D'Angelo, Michael
• Assistant Examiner(s): JANG, CHRISTIAN YONGKYUN
• Application Number:
  US13/949,088
• Publication Number:
  US 20130310666A1
• Time in Patent Office: 525 Days
• Field of Search: 600/309, 600/310, 600/316, 600/345, 600/347, 600/365
• US Class Current: 600/345
• CPC Class Codes: A61B 2562/17 Comprising radiolucent components
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14558 by polarisation
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

Claims

1. An implantable optical-based continuous glucose sensing device, the device comprising:

a radiation source;

an optical sensor configured to measure a signal indicative of glucose concentration;

sensor electronics operably connected to the sensor;

a housing configured to receive the radiation source, the optical sensor, and the sensor electronics; and

a membrane configured to interface with tissue;

wherein the membrane comprises an outer surface and an inner surface, wherein the outer surface of the membrane is more distal to the sensor than the inner surface of the membrane, wherein the outer surface of the membrane comprises partial metallization.

2. The device of claim 1, wherein the metallization comprises platinum.

3. The device of claim 1, wherein the metallization comprises vacuum deposited metal.

4. The device of claim 1, further comprising fluorescence sensing molecules configured to detect a presence of glucose.

5. The device of claim 1, wherein the membrane is configured to protect the sensor from in vivo environmental conditions.