Lipid coating for medical devices delivering bioactive agent
First Claim
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1. A medical device comprising:
- a balloon,a coating on all or a portion of the balloon, the coating comprising (i) nano- or microparticles that comprise a bioactive agent and (ii) a flexible hydrogel matrix, anda lipid coating on the coating comprising the bioactive agent, the lipid coating having a melting or softening point greater than room temperature and less than body temperature of the subject and comprising a plurality of fatty acids;
the device being effective for delivering the bioactive agent to a site within a subject.
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Abstract
The present invention relates compositions for delivering therapeutic agents from a medical device including an expandable and collapsible structure and methods employing them. A lipid coating including one or more fatty acids increases the amount of therapeutic agent released from the device at the delivery site. The therapeutic agent can be in a matrix including a hydrophilic polymer or an amphiphilic polymer. Release and adhesion coatings can also facilitate delivery of therapeutic agent.
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Citations
17 Claims
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1. A medical device comprising:
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a balloon, a coating on all or a portion of the balloon, the coating comprising (i) nano- or microparticles that comprise a bioactive agent and (ii) a flexible hydrogel matrix, and a lipid coating on the coating comprising the bioactive agent, the lipid coating having a melting or softening point greater than room temperature and less than body temperature of the subject and comprising a plurality of fatty acids; the device being effective for delivering the bioactive agent to a site within a subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification