Granules of porous biocompatible materials
First Claim
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1. A composition comprising a plurality of granules suspended in a biocompatible fluid the plurality of granules consisting of a porous synthetic polymer, the porous synthetic polymer having a plurality of substantially connected pores, wherein pores within the granules range from about 20 μ
- m to about 90 μ
m in diameter and wherein each granule has a volume that is at least the volume of a sphere of at least about 0.1 mm diameter equivalent and not more than the volume of a sphere of about 2 mm diameter equivalent, wherein the granules are capable of being recoverably compressed, and wherein the porous synthetic polymer is selected from the group consisting of poly (2-hydroxyethyl methacrylate) (HEMA), medical-grade silicone, poly (epsilon-caprolactone) dimethylacrylate, polysulfone, (poly)methyl methacrylate (PMMA), soluble copolymers of tetrafluoroethylene and perfluoro-2,2-dimethyl- 1,3-dioxole, polyethylene teraphthalate (PET), nylon, polyvinyl alcohol, polyurethane, and mixtures thereof.
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Abstract
The disclosure provides granular forms of porous biomaterials and methods for forming and applying these biomaterials, including uses to promote vascularization and tissue ingrowth.
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Citations
16 Claims
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1. A composition comprising a plurality of granules suspended in a biocompatible fluid the plurality of granules consisting of a porous synthetic polymer, the porous synthetic polymer having a plurality of substantially connected pores, wherein pores within the granules range from about 20 μ
- m to about 90 μ
m in diameter and wherein each granule has a volume that is at least the volume of a sphere of at least about 0.1 mm diameter equivalent and not more than the volume of a sphere of about 2 mm diameter equivalent, wherein the granules are capable of being recoverably compressed, and wherein the porous synthetic polymer is selected from the group consisting of poly (2-hydroxyethyl methacrylate) (HEMA), medical-grade silicone, poly (epsilon-caprolactone) dimethylacrylate, polysulfone, (poly)methyl methacrylate (PMMA), soluble copolymers of tetrafluoroethylene and perfluoro-2,2-dimethyl- 1,3-dioxole, polyethylene teraphthalate (PET), nylon, polyvinyl alcohol, polyurethane, and mixtures thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
- m to about 90 μ
Specification