Platelet preservation package comprising a short to ultra-short acting antiplatelet agent and anticoagulant
First Claim
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1. A platelet preservation package, comprising:
- a platelet preservation composition comprising;
a short-to-ultrashort acting antiplatelet agent, wherein said antiplatelet agent is a GPIIb/IIIa inhibitor;
a short-to-ultrashort acting anticoagulant, wherein said anticoagulant is a compound that reversibly inhibits factor Xa, or factor IIa, or both; and
a bag for storing the platelet preservation composition,wherein said antiplatelet agent and said anticoagulant are stored in said bag and wherein said composition is capable of extending the shelf-life of platelets when mixed with said platelets in said bag.
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Abstract
The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.
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13 Claims
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1. A platelet preservation package, comprising:
- a platelet preservation composition comprising;
a short-to-ultrashort acting antiplatelet agent, wherein said antiplatelet agent is a GPIIb/IIIa inhibitor; a short-to-ultrashort acting anticoagulant, wherein said anticoagulant is a compound that reversibly inhibits factor Xa, or factor IIa, or both; and a bag for storing the platelet preservation composition, wherein said antiplatelet agent and said anticoagulant are stored in said bag and wherein said composition is capable of extending the shelf-life of platelets when mixed with said platelets in said bag. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- a platelet preservation composition comprising;
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12. A platelet preservation package, comprising:
- a platelet preservation composition comprising;
a short-to-ultrashort acting antiplatelet agent, wherein said antiplatelet agent is a GPIIb/IIIa inhibitor; a short-to-ultrashort acting anticoagulant, wherein said anticoagulant is a compound that reversibly inhibits factor Xa; and a blood collection bag, wherein said antiplatelet agent and said anticoagulant are stored in said blood collection bag and wherein said composition is capable of extending the shelf-life of platelets when mixed with said platelets in said blood collection bag.
- a platelet preservation composition comprising;
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13. A platelet preservation package, comprising:
- a platelet preservation composition comprising;
a short-to-ultrashort acting antiplatelet agent, wherein said antiplatelet agent is a GPIIb/IIIa inhibitor; a short-to-ultrashort acting anticoagulant, wherein said anticoagulant is a compound that reversibly inhibits factor IIa; and a blood collection bag, wherein said antiplatelet agent and said anticoagulant are stored in said blood collection bag and wherein said composition is capable of extending the shelf-life of platelets when mixed with said platelets in said blood collection bag.
- a platelet preservation composition comprising;
Specification