Methods for reprogramming somatic cells
First Claim
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1. A composition comprising an isolated primary somatic cell that comprises an exogenously introduced Oct4 protein and an exogenously introduced Sox2 or Nanog protein.
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Abstract
The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated state.
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8 Claims
- 1. A composition comprising an isolated primary somatic cell that comprises an exogenously introduced Oct4 protein and an exogenously introduced Sox2 or Nanog protein.
- 6. The composition of 1, comprising a candidate agent of interest with respect to its potential to reprogram a somatic cell.
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