Modified polymeric materials and methods of modifying polymeric materials

• US 8,927,616 B2
• Filed: 11/02/2011
• Issued: 01/06/2015
• Est. Priority Date: 11/03/2010
• Status: Active Grant

• Current Assignee: Zimmer Incorporated (Zimmer Biomet Holdings, Inc.)
• Original Assignee: Zimmer Incorporated (Zimmer Biomet Holdings, Inc.)
• Inventors: Thomas, Brian H., Yakimicki, Donald L., Popoola, Oludele O., Wallick, Michael
• Primary Examiner(s): Nutter, Nathan M
• Application Number:
  US13/882,865
• Publication Number:
  US 20140031496A1
• Time in Patent Office: 1,161 Days
• Field of Search: 522/126, 522/127, 522/129, 522/130, 522/134, 522/146, 623/16.11, 623/18.11, 623/19.11, 623/20.11, 623/20.14, 623/21.11, 623/22.11, 623/22.39
• US Class Current: 522/126
• CPC Class Codes: A61L 27/16 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: B29C 43/02 of articles of definite length, i.e. discrete articles B29C35/0227 takes precedence
• CPC Class Codes: C08J 3/28 Treatment by wave energy or particle radiation
• CPC Class Codes: C08L 23/06 Polyethene

Abstract

Methods of forming polymeric articles using plasma treated polymer resins, and orthopedic implants comprising a polymeric article wherein the polymeric article has reactive groups bonded to polymer molecules in an interior region of the polymeric article.

Claims

1. A method of forming a polymeric article suitable for use as an orthopedic implant, the method comprising:

providing or receiving particles of a polymer resin;

exposing the particles of the polymer resin to a plasma, the plasma reacting with the particles of the polymer resin to bond one or more selected reactive groups to the particles; and

molding a polymeric article from the polymer resin after exposing the polymer resin to the plasma.

2. The method of claim 1, wherein the plasma is formed from a gas selected from the group consisting of nitric oxide, carbon dioxide, ammonia, allylamine, and combinations thereof.

3. The method of claim 1, wherein the one or more selected reactive groups are selected from the group consisting of amines, amides, imides, carboxyl, carbonyl, hydroxyl, sulfonates, phosphates, perfluoro and combinations thereof.

4. The method of claim 1, further comprising blending the particles of the polymer resin with an additive.

5. The method of claim 4, wherein the additive is selected from the group consisting of an antioxidant, an antibiotic, an antimicrobial, and an anti-inflammatory.

6. The method of claim 4, wherein the blending occurs after exposure of the particles to the plasma.

7. The method of claim 1, wherein molding comprises compression molding the polymer resin.

8. The method of claim 1, wherein the polymer resin is selected from the group consisting of as polyethylene, ultrahigh molecular weight polyethylene, polyaryletherketones, polypropylene, polyurethanes, acrylic resin, polyethylene-co-vinyl alcohol, nylon, polysulfones, polycarbonates, and polyacrylamides or combinations thereof.

9. The method of claim 1, wherein the particles of the polymer resin include polymer molecules, and the method further comprises crosslinking the polymer molecules prior to or after molding.

10. The method of claim 9, wherein the crosslinking comprises irradiating the polymeric article.

11. The method of claim 9, wherein the reactive groups are crosslinking agents and crosslink the polymer.

12. A method of forming a polymeric article suitable for use as an orthopedic implant, the method comprising:

providing or receiving particles of a first polymer resin;

exposing particles of a first polymer resin to a first plasma, including reacting the particles of the first polymer resin with the first plasma to bond one or more selected reactive groups to the particles of the first polymer resin;

exposing particles of a second polymer resin to a second plasma, including reacting the particles of the second polymer resin to bond one or more selected reactive groups to the particles of the second resin;

and

consolidating the first and second polymer resins to form a polymeric article that includes different reactive groups located in different regions of the polymer article.

13. The method of claim 12, wherein consolidating the first and second polymer resins comprises mixing the first and second resins together prior to forming the polymeric article.

14. The method of claim 12, wherein the first polymer resin and the second polymer resin comprise the same polymer.

15. A method of forming a polymeric article suitable for use as a medical implant, the method comprising:

providing a plasma-modified polymer resin having one or more reactive groups bonded to particles of the plasma-modified polymer resin; and

molding a polymeric article from the plasma-modified polymer resin, the one or more reactive groups located at least at an interior region of the polymeric article.

16. The method of claim 15, wherein the polymer resin is selected from the group consisting of polyethylene, ultrahigh molecular weight polyethylene, polyaryletherketones, polypropylene, and combinations thereof.

20. The method of claim 15, wherein the one or more reactive groups provide one or more properties to the polymeric article, the one or more properties selected from the group consisting of crosslinking, lubricity, wettability, hydrophobicity, hydrophilicity, wear resistance, tissue attachment, protein binding, reducing adverse biological reactions, reducing a chronic inflammatory response, reducing production of degrading enzymes and destructive species, and combinations thereof.

17. An orthopedic implant, comprising:

an article comprising a polymer, the article having an outer surface and an interior region;

the polymer including a plurality of polymer molecules having one or more reactive groups bonded thereto, the one or more reactive groups providing one or more properties selected from the group consisting of crosslinking, lubricity, wettability, hydrophobicity, hydrophilicity, wear resistance, tissue attachment, protein binding, reducing adverse biological reactions, reducing a chronic inflammatory response, reducing production of degrading enzymes and destructive species, and combinations thereof; and

the plurality of polymer molecules being located at least at the interior region of the polymeric article.

18. The implant of claim 17, wherein the one or more reactive groups are located substantially throughout the interior region and at the outer surface of the article.

19. The implant of claim 17, wherein the one or more reactive groups are located in selective portions of the polymeric article.