Crosslinkable polyisobutylene-based polymers and medical devices containing the same

• US 8,927,660 B2
• Filed: 08/26/2013
• Issued: 01/06/2015
• Est. Priority Date: 08/21/2009
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Desai, Shrojalkumar, Boden, Mark W.
• Primary Examiner(s): GULLEDGE, BRIAN M
• Application Number:
  US13/975,896
• Publication Number:
  US 20140088218A1
• Time in Patent Office: 498 Days
• Field of Search: None
• US Class Current: 525/455
• CPC Class Codes: A61L 27/16 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 31/048 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08F 10/10 Isobutene
• CPC Class Codes: C08F 110/10 Isobutene
• CPC Class Codes: C08F 2810/40 taking place solely at one end or both ends of the polymer backbone, i.e. not in the side or lateral chains
• CPC Class Codes: C08F 8/00 Chemical modification by after-treatment graft polymers, block polymers, crosslinking with unsaturated monomers or with polymers C08F251/00 - C08F299/00; of conjugated diene rubbers C08C
• CPC Class Codes: C08G 18/6204 Polymers of olefins unsaturated polymers of conjugated dienes C08G18/69
• CPC Class Codes: C08G 18/69 Polymers of conjugated dienes hydrogenated polymers of conjugated dienes C08G18/6208
• CPC Class Codes: C08L 23/20 having four to nine carbon atoms
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

The present invention pertains to crosslinkable and crosslinked polyisobutylene-based polymers, to compositions that contain such polymers, and to medical devices that are formed using such polymers. According to one aspect, the present invention pertains to crosslinkable and crosslinked compositions that comprise a copolymer that comprises a polyisobutylene segment and two or more reactive groups. According to another aspect, the present invention pertains to medical devices that contain such compositions. According to another aspect, the present invention pertains to methods of making medical devices using such compositions.

Claims

1. A medical device comprising a polymeric region that comprises:

a crosslinked urethane, urea or urethane/urea copolymer

a polyisobutylene segment; and

a crosslinking agent residue, wherein the crosslinking agent residue includes a free radical initiator residue.

2. The medical device of claim 1, wherein said polymeric region is a coating or adhesive layer that is applied to a medical device component.

3. The medical device of claim 1, wherein said polymeric region is a molded or extruded medical device component.

4. The medical device of claim 1, wherein said medical device is selected from stent, a heart valve, an implantable electrical lead, a pacemaker, a defibrillator and a heart failure device.

5. The medical device of claim 1, wherein said polymeric region further comprises a therapeutic agent.

6. The medical device of claim 1, wherein said polymeric region further comprises a supplemental agent including fluoroscopy markers.

7. The medical device of claim 6, wherein in the fluoroscopy marker is calcium tungstate.

8. The medical device of claim 1, wherein said polymeric region further comprises a supplemental agent including at least one of organically modified silicate, alumina, silver nanoparticles, and silicate/alumina/silver nanoparticle composites.

9. The medical device of claim 1, wherein said polymeric region includes one or more fibers which are incorporated into a medical device component.

10. The medical device of claim 1, wherein the free radical initiator residue is a free radical thermal initiator residue.

11. The medical device of claim 1, wherein the free radical initiator residue is a free radical photoinitiator.