PD-1 specific antibodies and uses thereof
First Claim
1. An isolated antibody selected from:
- a) a monoclonal antibody that binds PD-1 and is produced by the hybridoma clone 10 or antigen binding fragment thereof, said hybridoma clone being deposited with the European Collection of Cell Cultures (ECACC) under accession number 08090902;
b) an isolated antibody that binds PD-1 or antigen binding fragment comprising SEQ ID NO;
8 and SEQ ID NO;
10;
orc) a bispecific, humanized, single-chain, chimeric, synthetic or recombinant antibody that binds PD-1 comprising a light chain variable region comprising SEQ ID NO;
21 (light chain CDR1), SEQ ID NO;
22 (light chain CDR2), SEQ ID NO;
23 (light chain CDR3) and a heavy chain variable region comprising SEQ ID NO;
24 (heavy chain CDR1), SEQ ID NO;
25 (heavy chain CDR2) and SEQ ID NO;
26 (heavy chain CDR3).
2 Assignments
0 Petitions
Accused Products
Abstract
One aspect of the present disclosure provides antibodies that can act as agonists of PD-1, thereby modulating immune responses regulated by PD-1. Another aspect of the disclosure provides compositions comprising PD-1 specific antibodies and their use in methods of down regulating the immune response. These methods can be practiced on any subject, including humans or animals. Anti-PD-1 antibodies disclosed herein may be used, in another aspect of the invention, to detect PD-1 or its fragments in a biological sample. The amount of PD-1 detected may be correlated with the expression level of PD-1, and associated with the activation status of immune cells (e.g., activated T cells, B cells, and/or monocytes) in the subject.
-
Citations
10 Claims
-
1. An isolated antibody selected from:
-
a) a monoclonal antibody that binds PD-1 and is produced by the hybridoma clone 10 or antigen binding fragment thereof, said hybridoma clone being deposited with the European Collection of Cell Cultures (ECACC) under accession number 08090902; b) an isolated antibody that binds PD-1 or antigen binding fragment comprising SEQ ID NO;
8 and SEQ ID NO;
10;
orc) a bispecific, humanized, single-chain, chimeric, synthetic or recombinant antibody that binds PD-1 comprising a light chain variable region comprising SEQ ID NO;
21 (light chain CDR1), SEQ ID NO;
22 (light chain CDR2), SEQ ID NO;
23 (light chain CDR3) and a heavy chain variable region comprising SEQ ID NO;
24 (heavy chain CDR1), SEQ ID NO;
25 (heavy chain CDR2) and SEQ ID NO;
26 (heavy chain CDR3). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
Specification