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PD-1 specific antibodies and uses thereof

  • US 8,927,697 B2
  • Filed: 09/14/2009
  • Issued: 01/06/2015
  • Est. Priority Date: 09/12/2008
  • Status: Active Grant
First Claim
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1. An isolated antibody selected from:

  • a) a monoclonal antibody that binds PD-1 and is produced by the hybridoma clone 10 or antigen binding fragment thereof, said hybridoma clone being deposited with the European Collection of Cell Cultures (ECACC) under accession number 08090902;

    b) an isolated antibody that binds PD-1 or antigen binding fragment comprising SEQ ID NO;

    8 and SEQ ID NO;

    10;

    orc) a bispecific, humanized, single-chain, chimeric, synthetic or recombinant antibody that binds PD-1 comprising a light chain variable region comprising SEQ ID NO;

    21 (light chain CDR1), SEQ ID NO;

    22 (light chain CDR2), SEQ ID NO;

    23 (light chain CDR3) and a heavy chain variable region comprising SEQ ID NO;

    24 (heavy chain CDR1), SEQ ID NO;

    25 (heavy chain CDR2) and SEQ ID NO;

    26 (heavy chain CDR3).

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