Arrangements and methods for providing multimodality microscopic imaging of one or more biological structures
First Claim
1. An apparatus comprising:
- at least one source first arrangement configured to provide an electro-magnetic light radiation; and
at least one second arrangement configured to provide (i) first data associated with a first signal received from at least one region of at least one sample based on a first modality, (ii) second data associated with a second signal received from the at least one sample based on a second modality which is different from the first modality, and (iii) at least one third data associated with a third signal received from the at least one sample, wherein each of the at least one third data is based on a third modality which is different from at least one of the first modality or the second modality,wherein at least two of the first, second and third signals are caused by the electro-magnetic light radiation provided by the at least one source first arrangement.
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Abstract
Method and apparatus according to an exemplary embodiment of the present invention can be provided. For example, first data associated with a first signal received from at least one region of at least one sample can be provided based on a first modality, and second data associated with a second signal received from the at least one sample can be provided based on a second modality which is different from the first modality. Third data associated with a reference can be received. Further data can be generated based on the first, second and third data. In addition, third data associated with a second signal received from the at least one sample can be obtained. Each of the third data can be based on a further modality which is different from the first modality and the second modality, and the further data can be further determined based on the third data. Further, the first modality can be a spectral-encoded modality, and the second modality can be a non-spectral-encoding modality.
554 Citations
24 Claims
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1. An apparatus comprising:
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at least one source first arrangement configured to provide an electro-magnetic light radiation; and at least one second arrangement configured to provide (i) first data associated with a first signal received from at least one region of at least one sample based on a first modality, (ii) second data associated with a second signal received from the at least one sample based on a second modality which is different from the first modality, and (iii) at least one third data associated with a third signal received from the at least one sample, wherein each of the at least one third data is based on a third modality which is different from at least one of the first modality or the second modality, wherein at least two of the first, second and third signals are caused by the electro-magnetic light radiation provided by the at least one source first arrangement. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An apparatus comprising:
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at least one source first arrangement which is configured to provide an electro-magnetic radiation; and at least one second arrangement configured to provide (i) first data associated with a first signal received from at least one region of at least one sample based on a spectral-encoding first modality, and (ii) second data associated with a second signal received from the at least one sample based on a non-spectral-encoding second modality, wherein at least one of the first signal or the second signal is cause by the electro-magnetic radiation provided by the at least one first arrangement. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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21. A method comprising:
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providing an electro-magnetic light radiation using at least one source arrangement; and providing (i) first data associated with a first signal received from at least one region of at least one sample based on a first modality, (ii) second data associated with a second signal received from the at least one sample based on a second modality which is different from the first modality, and (iii) at least one third data associated with a third signal received from the at least one sample, wherein each of the at least one third data is based on a third modality which is different from at least one of the first modality or the second modality, wherein the first and second signals are caused by the electro-magnetic light radiation provided by the at least one source arrangement.
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22. A method comprising:
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providing an electro-magnetic light radiation using at least one source arrangement; and providing (i) first data associated with a first signal received from at least one region of at least one sample based on a spectral-encoding first modality, and (ii) second data associated with a second signal received from the at least one sample based on a non-spectral-encoding second modality, wherein at least one of the first signal or the second signal is caused by the electro-magnetic light radiation provided by the at least one source arrangement.
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23. An apparatus, comprising:
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at least one source first arrangement configured to provide a first light radiation to at least one region of at least one sample and a second light radiation to the at least one region of the at least one sample; and a detection arrangement configured to provide; (i) first data associated with a first signal received from the at least one region of at least one sample based on optical coherence tomography (OCT) that is a first modality, wherein the first signal is caused by the first light radiation, (ii) second data associated with a second signal received from the at least one sample based on a fluorescence that is a second modality, wherein the second signal is caused by the second light radiation, and (iii) at least one third data associated with a third signal provided from the at least one sample, wherein the at least one third data is based on a third modality that is different from at least one of the first modality or the second modality. - View Dependent Claims (24)
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Specification