Apparatus and method for magnetic resonance measurement and mapping of electrical impedance, complex permittivity and complex conductivity as applied to detection and evaluation of sample pathology

• US 8,929,970 B2
• Filed: 05/15/2012
• Issued: 01/06/2015
• Est. Priority Date: 08/30/2002
• Status: Expired due to Fees

• Current Assignee: Wollin Ventures, Inc.
• Original Assignee: Wollin Ventures, Inc.
• Inventors: Wollin, Ernest
• Primary Examiner(s): TOWA, RENE T
• Application Number:
  US13/472,084
• Publication Number:
  US 20120223712A1
• Time in Patent Office: 966 Days
• Field of Search: 600/407, 600410-411, 600/415, 600421-422, 600/425, 600/427, 600/547, 324/307, 324/309
• US Class Current: 600/407
• CPC Class Codes: A61B 5/0035 adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/708 Breast positioning means
• CPC Class Codes: G01R 33/28 Details of apparatus provided for in groups G01R33/44 - G01R33/64
• CPC Class Codes: G01R 33/30 Sample handling arrangements, e.g. sample cells, spinning mechanisms
• CPC Class Codes: G01R 33/422 of the radio frequency field
• CPC Class Codes: G01R 33/4808 Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]

Abstract

A method of measurement of or mapping the distribution of complex permittivity, complex conductivity, complex impedance, or electric loss angle during magnetic resonance imaging or analysis. The method includes applying a time-varying electric field of a Faraday shield to a sample and cross-correlating the line spectrum signal so produced with the voltage applied to the Faraday shield in a detection circuit. The method permits non-contrast magnetic resonance screening for breast cancer in vivo and/or continuous measurement of electrical characteristics of materials at variable frequencies in vitro. A system of detecting and evaluating sample pathology includes a Faraday shield device that includes parallel electrodes oriented orthogonal to the static magnetic field of a MRI device to produce a time varying electric field. A detector is coupled to the MRI device to detect at least one of a complex permittivity, a complex conductivity, and an electrical impedance of the sample.

Claims

1. A method of detecting and evaluating sample spatially ordered pathology, comprising:

placing an in-vivo human tissue sample to be evaluated within a magnetic resonance imaging device in proximity to a Faraday shield device, wherein the Faraday shield device comprises Faraday shields oriented so as not to significantly affect a radio frequency field generated within the magnetic resonance imaging device, and an insulating material that insulates the in-vivo human tissue sample from the Faraday shields, whereby the Faraday shield device is configured to apply a time varying potential difference to the in-vivo human tissue sample;

applying a time varying potential difference to the Faraday shield device, so as to create a time varying electric field in the in-vivo human tissue sample and a local time varying current field in the in-vivo human tissue sample essentially orthogonal to the main magnetic field generated by the magnetic resonance imaging device which results in a periodic aberration in a local magnetic field that periodically varies a phase of spins within the in-vivo human tissue sample; and

imaging at least one of a complex permittivity, a complex conductivity, and an electrical impedance of the in-vivo human tissue sample during the application of the time varying potential difference to the Faraday shield device.

2. The method according to claim 1, wherein the in-vivo human tissue sample is a human breast, and wherein the Faraday shield device further comprises a pair of compression paddles containing the Faraday shields oriented in parallel to each other, wherein the compression paddles substantially align with a main magnetic field of the magnetic resonance imaging device.

3. The method according to claim 2, wherein the Faraday shields comprise electrically connected substantially parallel conducting elements oriented substantially orthogonal to the main magnetic field of the magnetic resonance imaging device.

4. The method according to claim 3, wherein the compression paddles are non-conductive, the insulating material has a high dielectric constant, and the conducting elements are coupled to a voltage source that applies the time varying potential difference across the conducting elements.

5. The method according to claim 4, wherein the insulating material comprises one or more ferroelectric materials.

6. The method according to claim 3, wherein the substantially parallel conducting elements each comprises a maximum width substantially less than the length of each substantially parallel conducting element.

7. The method according to claim 6, wherein each substantially parallel conducting element is electrically insulated from each adjoining substantially parallel conducting element.

8. The method according to claim 1, further comprising:

analyzing an image of the in-vivo human tissue sample produced by the magnetic resonance imaging device during the application of the time varying potential difference to the Faraday shield device to detect at least one of a complex permittivity, a complex conductivity, and an electrical impedance of the in-vivo human tissue sample; and

identifying focal aberrations contained only in the image produced by the magnetic resonance imaging device and analyzed so as to locate pathology.

9. The method according to claim 1, further comprising detecting orthogonal components of each sideband of a line spectrum resolved with respect to the phase of the time varying potential difference applied to the Faraday shield device at a frequency (Ω

) much less than the Larmor frequency of the magnetic resonance imaging device (ω

₀).

10. The method according to claim 9, further comprising determining a ratio of the resolved real and imaginary components of the sidebands.

11. The method according to claim 1, wherein the in-vivo human tissue sample is a portion of a human breast.

12. The method according to claim 1, wherein the time varying potential difference is continuously applied.

13. The method according to claim 1, wherein the time varying potential is pulsed.

14. The method according to claim 1, wherein the time varying potential is timed to an event sequence of the magnetic resonance imaging device.

15. The method according to claim 1, wherein the Faraday shield device does not provide a conduction path either for the electric field associated with the radio frequency field generated within the magnetic resonance imaging device or for eddy currents resulting from the application of gradients by the magnetic resonance imaging device.

16. A system for detecting and evaluating sample pathology, comprising:

a magnetic resonance imaging device configured to produce an image of an in-vivo human tissue sample, the magnetic resonance imaging device generating a main magnetic field and including i) a receiving coil and a transmitting coil or ii) a transmitter-receiver coil;

a Faraday shield device comprising Faraday shields that include an insulating material that insulates the in-vivo human tissue sample from the Faraday shields oriented so as not to significantly affect a radio frequency field generated within the magnetic resonance imaging device, and electrically connected, substantially parallel conducting elements oriented substantially orthogonal to the main magnetic field of the magnetic resonance imaging device, whereby the Faraday shield device is configured to produce a time varying electric field in the in-vivo human tissue sample;

a voltage source coupled to the conducting elements and configured to generate a periodic voltage at a frequency (1) creating a current in the in-vivo human tissue sample essentially orthogonal to the main magnetic field of the magnetic resonance device; and

a detector configured to analyze an image of the in-vivo human tissue sample produced by the magnetic resonance imaging device to detect one of a complex permittivity, a complex conductivity, and an electrical impedance of the in-vivo human tissue sample, wherein the analyzed image is produced during production of the time varying electric field by the Faraday shield device.

17. The system according to claim 16, wherein the Faraday shield device comprises a pair of low-conductivity compression paddles containing the Faraday shields.

18. The system according to claim 16, wherein the periodic voltage is continuously applied.

19. The system according to claim 16, wherein the voltage source is pulsed.

20. The system according to claim 16, wherein the voltage source is timed to an event sequence of the magnetic resonance imaging device.

21. The system according to claim 16, wherein the in-vivo human tissue sample is a portion of a human breast.

22. The system according to claim 16, wherein the detector is configured to detect orthogonal components of each sideband of a line spectrum resolved with respect to the phase of the time varying electric field produced by the Faraday shield device at a frequency (Ω

) much less than the Larmor frequency of the magnetic resonance imaging device (ω

₀).

23. The system according to claim 22, wherein the detector is configured to determine a ratio of the resolved real and imaginary components of the sidebands.