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Systems and methods for improved stability of electrochemical sensors

  • US 8,932,445 B2
  • Filed: 09/30/2010
  • Issued: 01/13/2015
  • Est. Priority Date: 09/30/2010
  • Status: Active Grant
First Claim
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1. A method for determining a concentration of an analyte in a sample, the method comprising:

  • introducing a sample including an analyte into an electrochemical cell of a sample analyzing device to cause a transformation of the analyte, the electrochemical cell having a first electrode and a second electrode;

    determining a measurement of a parameter correlating to a physical property of the electrochemical cell, said parameter comprising a measured capacitance of the electrochemical cell;

    calculating a correction factor, wherein said correction factor is in view of at least said parameter; and

    determining a first analyte concentration and a corrected concentration of the analyte in view of the correction factor, wherein determining said measured capacitance of the electrochemical cell further comprises;

    applying a first test voltage between the first electrode and the second electrode after the presence of sample has been detected in the test strip for a first time interval to determine whether sample or a control solution has been introduced into the test strip;

    applying a second test voltage between the first electrode and the second electrode for a second time interval sufficient to oxidize a reduced mediator at the second electrode, the second test voltage having a higher absolute magnitude than that of the first test voltage, the second test voltage having an AC voltage component and a DC voltage component, the AC voltage component being applied at a predetermined amount of time after the application of the second test voltage, the DC voltage component having a magnitude to cause a limiting test current at the second electrode, the second electrode not having a reagent layer coating;

    applying a third test voltage between the first electrode and the second electrode for a third time interval following the application of the second test voltage sufficient to oxidize a reduced mediator at the first electrode; and

    processing a portion of the test currents, resulting from the AC voltage component, into a capacitance value,and in which the first analyte concentration is calculated based on test current values during the second time interval and the third time interval and the corrected analyte concentration is calculated based on the first analyte concentration and the correction factor.

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