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Methods for reprogramming somatic cells

DC CAFC
  • US 8,932,856 B2
  • Filed: 10/05/2012
  • Issued: 01/13/2015
  • Est. Priority Date: 11/26/2003
  • Status: Active Grant
First Claim
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1. A method of making a somatic cell more susceptible to reprogramming to a pluripotent state comprising introducing at least one exogenous nucleic acid encoding Oct 4 operably linked to at least one regulatory sequence into the cell, thereby increasing expression of Oct4 protein in the somatic cell, wherein increased expression of Oct4 protein makes the cell more susceptible to reprogramming to a pluripotent state.

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