Drug-ligand conjugates, synthesis thereof, and intermediates thereto

• US 8,933,207 B2
• Filed: 07/22/2011
• Issued: 01/13/2015
• Est. Priority Date: 07/28/2010
• Status: Active Grant

• Current Assignee: SmartCells, Inc. (Merck & Co., Inc.)
• Original Assignee: SmartCells, Inc. (Merck & Co., Inc.)
• Inventors: Chen, Zhiyu, Lancaster, Thomas M., Zion, Todd C.
• Primary Examiner(s): AUDET, MAURY A
• Application Number:
  US13/811,745
• Publication Number:
  US 20130190475A1
• Time in Patent Office: 1,271 Days
• Field of Search: None
• US Class Current: 532/1
• CPC Class Codes: A61K 47/549 Sugars, nucleosides, nucleotides or nucleic acids
• CPC Class Codes: C07H 13/04 having the esterifying carboxyl radicals attached to acyclic carbon atoms
• CPC Class Codes: C07H 15/04 attached to an oxygen atom of the saccharide radical
• CPC Class Codes: C07H 15/26 Acyclic or carbocyclic radicals, substituted by hetero rings

Abstract

The present invention relates to methods for synthesizing compounds of formula I or pharmaceutically acceptable salts thereof: I wherein each of X, Alk₁, Alk₂, and W are as defined and described herein.

Claims

1. A compound of the formula