Measurement of chemical equilibrium ratio using a magnetic resonance spectroscopy system

• US 8,933,697 B2
• Filed: 12/19/2011
• Issued: 01/13/2015
• Est. Priority Date: 12/19/2011
• Status: Active Grant

• Current Assignee: General Electric Company
• Original Assignee: General Electric Company
• Inventors: Chen, Albert Po-Fu, Hurd, Ralph Eugene
• Primary Examiner(s): ARANA, LOUIS M
• Application Number:
  US13/330,451
• Publication Number:
  US 20130154637A1
• Time in Patent Office: 1,121 Days
• Field of Search: 324/307, 324/309, 324/312, 324/314, 324/300
• US Class Current: 324/307
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: G01R 33/4608 RF excitation sequences for enhanced detection, e.g. NOE, polarisation transfer, selection of a coherence transfer pathway
• CPC Class Codes: G01R 33/4804 Spatially selective measurement of temperature or pH
• CPC Class Codes: G01R 33/485 based on chemical shift information [CSI] or spectroscopic imaging, e.g. to acquire the spatial distributions of metabolites

Abstract

The use of selective RF excitation is discussed. A spectrally selective, large tip angle RF pulse is used to detect a weak signal from a first chemical species. A non-selective, small tip angle pulse is used in measuring a signal from a second chemical species in exchange with the first chemical species. The acquired resonance data provides maybe used to measure the ratio of the spectrally distinct species in exchange.

Claims

1. A method for measuring a ratio of two or more spectrally distinct chemical species in exchange, the method comprising the steps of:

generating a first RF excitation pulse that selectively tips a first chemical species by a first tip angle;

quantifying the first chemical species based on resonance signals generated in response to the first RF excitation pulse;

under equilibrium conditions between the first chemical species and a second chemical species, generating a second RF excitation pulse that tips at least the second chemical species by a second tip angle that is different than the first tip angle;

quantifying the second chemical species based on resonance signals generated in response to the second RF excitation pulse;

repeating, for a set number of iterations, the steps of generating the first RF excitation pulse, quantifying the first chemical species, generating the second RF excitation pulse, and quantifying the second chemical species; and

obtaining a ratio of the first chemical species and the second chemical species in exchange correcting for the differential effect of the first tip angle and the second tip angle.

2. The method of claim 1, wherein the steps of generating the first RF excitation pulse and generating the second RF excitation pulse are interleaved.

3. The method of claim 1, wherein the steps of generating the first RF excitation pulse and generating the second RF excitation pulse are performed simultaneously using a multiband RF pulse.

4. The method of claim 1, comprising the step of determining a pH based on the ratio.

5. The method of claim 1, wherein the step of repeating averages a resonance signal acquired for the first chemical species.

6. The method of claim 1, wherein the step of repeating provides a time resolved measure or spatial encoding of an exchange ratio between the first chemical species and the second chemical species.

7. The method of claim 1, wherein the second tip angle substantially preserves the total exchange pool of the first chemical species and the second chemical species.

8. The method of claim 1, wherein the second tip angle substantially preserves the total exchange pool of the first chemical species and the second chemical species.

9. The method of claim 1, wherein the first tip angle increases a signal-to-noise ratio for the first chemical species relative to the second tip angle.

10. A memory structure physically encoding one or more executable routines which, when executed, cause acts to be performed comprising:

generating a first RF excitation pulse that selectively tips a first chemical species by a first tip angle;

quantifying the first chemical species based on resonance signals generated in response to the first RF excitation pulse;

under equilibrium conditions between the first chemical species and a second chemical species, generating a second RF excitation pulse that tips at least the second chemical species by a second tip angle that is different than the first tip angle;

quantifying the second chemical species based on resonance signals generated in response to the second RF excitation pulse;

repeating, for a set number of iterations, the steps of generating the first RF excitation pulse, quantifying the first chemical species, generating the second RF excitation pulse, and quantifying the second chemical species; and

obtaining a ratio of the first chemical species and the second chemical species in exchange correcting for the differential effect of the first tip angle and the second tip angle.

11. The memory structure of claim 10, wherein the first RF excitation pulse and the second RF excitation pulse are interleaved.

12. The memory structure of claim 10, wherein the first RF excitation pulse and the second RF excitation pulse are generated simultaneously using a multiband RF pulse.

13. The memory structure of claim 10, wherein the one or more executable routines, when executed, further cause an act to be performed comprising:

determining a pH based on the ratio.

14. The memory structure of claim 10, wherein the act of repeating averages a resonance signal acquired for the first chemical species.

15. A magnetic resonance spectroscopy system, comprising:

a primary field coil configured to generate a primary magnetic field within a volume;

a radio frequency (RF) coil configured to generate RF pulses;

one or more control circuits for controlling operation of the primary field coil and the RF coil;

a memory storing instructions to be executed by the one or more control circuits for implementing a pulse sequence, wherein the pulse sequence, when executed, causes

generation of a first RF excitation pulse that selectively tips a first chemical species by a first tip angle, wherein the first tip angle increases a signal-to-noise ratio for the first chemical species relative to a second tip angle that is different than the first tip angle;

under equilibrium conditions between the first chemical species and a second chemical species, generation of a second RF excitation pulse that tips at least the second chemical species by the second tip angle;

repetition, for a set number of iterations, of the acts of generating the first RF excitation pulse and generating the second RF excitation pulse.

16. The magnetic resonance spectroscopy system of claim 15, wherein the RF coil is also configured to function as a receive coil that detects resonance signals generated in response to the RF pulses.

17. The magnetic resonance spectroscopy system of claim 15, comprising a separate receive coil that that detects resonance signals generated in response to the RF pulses.

18. The magnetic resonance spectroscopy system of claim 15, wherein the first RF excitation pulse and the second RF excitation pulse are interleaved.

19. The magnetic resonance spectroscopy system of claim 15, wherein the first RF excitation pulse and the second RF excitation pulse are generated simultaneously using a multiband RF pulse.

20. The magnetic resonance spectroscopy system of claim 15, wherein the memory further stores instructions to be executed by the one or more control circuits for determining a ratio of the first chemical species and the second chemical species in exchange based on the differential effect of the first tip angle and the second tip angle.