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Method and apparatus for monitoring arrythmogenic effects of medications using an implantable device

  • US 8,934,963 B1
  • Filed: 01/16/2007
  • Issued: 01/13/2015
  • Est. Priority Date: 01/16/2007
  • Status: Active Grant
First Claim
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1. In an implantable system, a method for monitoring for an increase in arrhythmic vulnerability following administration of a medication other than an antiarrhythmic medication, comprising:

  • (a) during a first time period, substantially coincident with commencing the administration of the medication other than an antiarrhythmic medication, obtaining an electrogram (EGM) signal from a patient via the implantable system, and analyzing one or more attributes of T-waves of the EGM signal to generate a first metric representative of transmural dispersion of repolarization (TDR);

    (b) during a second time period, following the administration of the medication other than an antiarrhythmic medication, obtaining a further EGM signal from the patient via the implantable system, and analyzing one or more attributes of T-waves of the further EGM signal to generate a further metric representative of TDR;

    (c) determining an index indicative of a total increase in arrhythmic vulnerability and an index indicative of a rate of increase in arrhythmic vulnerability following the administration of the medication other than an antiarrhythmic medication by comparing the further metric representative of TDR to the first metric representative of TDR; and

    (d) triggering an alert signal if at least one of the index indicative of the total increase in arrhythmic vulnerability or the index indicative of the rate of increase in arrhythmic vulnerability is outside of acceptable bounds defined by one or more thresholds;

    wherein steps (a), (b) and (c) are performed by the implantable system; and

    wherein the one or more attributes of T-waves analyzed at steps (a) and (b) is/are the same and comprise(s) at least one of an interval from an apex to an end of T-waves, a peak amplitude of T-waves, a slope of T-waves, an area under the curve of T-waves, a morphology of T-waves, or a complexity of T-waves.

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