Method and apparatus for monitoring arrythmogenic effects of medications using an implantable device
First Claim
1. In an implantable system, a method for monitoring for an increase in arrhythmic vulnerability following administration of a medication other than an antiarrhythmic medication, comprising:
- (a) during a first time period, substantially coincident with commencing the administration of the medication other than an antiarrhythmic medication, obtaining an electrogram (EGM) signal from a patient via the implantable system, and analyzing one or more attributes of T-waves of the EGM signal to generate a first metric representative of transmural dispersion of repolarization (TDR);
(b) during a second time period, following the administration of the medication other than an antiarrhythmic medication, obtaining a further EGM signal from the patient via the implantable system, and analyzing one or more attributes of T-waves of the further EGM signal to generate a further metric representative of TDR;
(c) determining an index indicative of a total increase in arrhythmic vulnerability and an index indicative of a rate of increase in arrhythmic vulnerability following the administration of the medication other than an antiarrhythmic medication by comparing the further metric representative of TDR to the first metric representative of TDR; and
(d) triggering an alert signal if at least one of the index indicative of the total increase in arrhythmic vulnerability or the index indicative of the rate of increase in arrhythmic vulnerability is outside of acceptable bounds defined by one or more thresholds;
wherein steps (a), (b) and (c) are performed by the implantable system; and
wherein the one or more attributes of T-waves analyzed at steps (a) and (b) is/are the same and comprise(s) at least one of an interval from an apex to an end of T-waves, a peak amplitude of T-waves, a slope of T-waves, an area under the curve of T-waves, a morphology of T-waves, or a complexity of T-waves.
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Abstract
An implantable device and method for monitoring changes in the risk of arrhythmia induced by medications. The implantable device monitors risk of arrhythmia by analyzing an aspect of T-wave morphology to generate a metric of transmural dispersion of repolarization (“TDR”) as a proxy for the risk of arrhythmia. The implantable device generates an index of change in the risk of arrhythmia by comparing values of the metric of TDR obtained for different time periods. The implantable device generates a warning if the change in risk of arrhythmia is outside acceptable limits. The implantable device can also communicate with other devices to correlate changes in risk of arrhythmia with medications taken by the patient.
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Citations
17 Claims
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1. In an implantable system, a method for monitoring for an increase in arrhythmic vulnerability following administration of a medication other than an antiarrhythmic medication, comprising:
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(a) during a first time period, substantially coincident with commencing the administration of the medication other than an antiarrhythmic medication, obtaining an electrogram (EGM) signal from a patient via the implantable system, and analyzing one or more attributes of T-waves of the EGM signal to generate a first metric representative of transmural dispersion of repolarization (TDR); (b) during a second time period, following the administration of the medication other than an antiarrhythmic medication, obtaining a further EGM signal from the patient via the implantable system, and analyzing one or more attributes of T-waves of the further EGM signal to generate a further metric representative of TDR; (c) determining an index indicative of a total increase in arrhythmic vulnerability and an index indicative of a rate of increase in arrhythmic vulnerability following the administration of the medication other than an antiarrhythmic medication by comparing the further metric representative of TDR to the first metric representative of TDR; and (d) triggering an alert signal if at least one of the index indicative of the total increase in arrhythmic vulnerability or the index indicative of the rate of increase in arrhythmic vulnerability is outside of acceptable bounds defined by one or more thresholds; wherein steps (a), (b) and (c) are performed by the implantable system; and wherein the one or more attributes of T-waves analyzed at steps (a) and (b) is/are the same and comprise(s) at least one of an interval from an apex to an end of T-waves, a peak amplitude of T-waves, a slope of T-waves, an area under the curve of T-waves, a morphology of T-waves, or a complexity of T-waves. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A system for implantation in a patient, comprising:
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a plurality of implantable electrodes configured to produce an electrogram (EGM) signal; and a controller configured to; analyze one or more attributes of T-waves of an EGM signal obtained during a first time period, substantially coincident with administration of a medication other than an antiarrhythmic medication, to generate a first metric representative of transmural dispersion of repolarization (TDR); analyze one or more attributes of T-waves of an EGM signal obtained during a second time period, following the administration of the medication other than an antiarrhythmic medication, to generate a further metric representative of TDR; determine an index indicative of a total increase in arrhythmic vulnerability and an index indicative of a rate of change in arrhythmic vulnerability following administration of the medication other than an antiarrhythmic medication by comparing the further metric representative of TDR to the first metric representative of TDR; and trigger an alert signal if at least one of the index indicative of the total increase in arrhythmic vulnerability or the index indicative of the rate of increase in arrhythmic vulnerability is outside of acceptable bounds defined by one or more thresholds; wherein the one or more attributes of T-waves obtained during the first and second time periods is/are the same and comprise(s) at least one of an interval from an apex to an end of T-waves, a peak amplitude of T-waves, a slope of T-waves, an area under the curve of T-waves, a morphology of T-waves, or a complexity of T-waves. - View Dependent Claims (12, 13, 14, 15, 16, 17)
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Specification