Systems, methods and devices for treating tinnitus
First Claim
Patent Images
1. A method of treating tinnitus in a patient, comprising:
- measuring a patient'"'"'s tinnitus symptoms;
selecting therapeutic sounds based on the measured tinnitus symptoms, wherein each therapeutic sound consists of only one frequency, and wherein the frequency is audible to the patient;
providing a repeated paired training therapy by providing a series of the therapeutic sounds paired with a vagus nerve stimulation pulse train by presenting the vagus nerve stimulation pulse train during presentation of the therapeutic sounds, wherein the vagus nerve stimulation pulse train is generated by a subcutaneous device that provides electrical stimulation of the patient'"'"'s vagus nerve;
repeatedly presenting the series of paired therapeutic sounds; and
reducing the patient'"'"'s perception of tinnitus.
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Abstract
Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training. Stimulations of nerves such as the vagus nerve that affect subcortical regions such as the nucleus basalis, locus coeruleus or amygdala induce plasticity in the brain, enhancing the effects of a variety of therapies, such as those used to treat tinnitus, stroke, traumatic brain injury and post-traumatic stress disorder.
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Citations
99 Claims
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1. A method of treating tinnitus in a patient, comprising:
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measuring a patient'"'"'s tinnitus symptoms; selecting therapeutic sounds based on the measured tinnitus symptoms, wherein each therapeutic sound consists of only one frequency, and wherein the frequency is audible to the patient; providing a repeated paired training therapy by providing a series of the therapeutic sounds paired with a vagus nerve stimulation pulse train by presenting the vagus nerve stimulation pulse train during presentation of the therapeutic sounds, wherein the vagus nerve stimulation pulse train is generated by a subcutaneous device that provides electrical stimulation of the patient'"'"'s vagus nerve; repeatedly presenting the series of paired therapeutic sounds; and reducing the patient'"'"'s perception of tinnitus. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method of treating tinnitus in a patient, comprising:
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assessing a patient'"'"'s tinnitus symptoms; selecting a therapeutic sound based on the assessed tinnitus symptoms, wherein the therapeutic sound consists of only one frequency, and wherein the frequency is audible to the patient; pairing the therapeutic sound with a vagus nerve stimulation pulse train originating from a device that provides electrical stimulation to the vagus nerve by presenting the vagus nerve stimulation pulse train during presentation of the therapeutic sound; repeating the step of selecting a therapeutic sound; repeating the step of pairing the therapeutic sound; and reducing the patient'"'"'s perception of tinnitus. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A method of treating tinnitus in a subject, comprising:
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assessing a subject'"'"'s tinnitus symptoms; selecting a plurality of therapeutic sounds based on the assessed tinnitus symptoms, wherein each therapeutic sound consists of only one frequency; repeatedly presenting a plurality of paired therapeutic sounds where one of the therapeutic sounds is paired by presenting a vagus nerve stimulation pulse train during presentation of the one therapeutic sound, wherein the vagus nerve stimulation pulse train is generated by a subcutaneous device that provides electrical stimulation of the subject'"'"'s vagus nerve; and reducing the subject'"'"'s perception of tinnitus. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A method of treating tinnitus in a subject, comprising:
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assessing a subject'"'"'s tinnitus symptoms; selecting a plurality of therapeutic sounds based on the assessed tinnitus symptoms, wherein each therapeutic sound consists of only one frequency; pairing the therapeutic sounds with a plurality of vagus nerve stimulation pulse trains originating from a device that provides electrical stimulation to the vagus nerve by presenting one of the vagus nerve stimulation pulse trains during presentation of one of the therapeutic sounds; repeatedly presenting the paired therapeutic sounds; and reducing the subject'"'"'s perception of tinnitus. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48, 49)
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50. A method of treating tinnitus in a patient, comprising:
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determining a patient'"'"'s tinnitus symptoms; selecting therapeutic sounds based on the determined tinnitus symptoms, wherein each therapeutic sound consists of only one frequency; pairing a plurality of therapeutic sounds with a plurality of vagus nerve stimulation pulse trains originating from a device that provides electrical stimulation to the vagus nerve by presenting one of the vagus nerve stimulation pulse trains during presentation of one of the therapeutic sounds; repeatedly presenting the plurality of paired therapeutic sounds; and reducing the patient'"'"'s perception of tinnitus. - View Dependent Claims (51, 52, 53, 54, 55, 56, 57, 58, 59, 60)
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61. A method of treating tinnitus in a subject, comprising:
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determining a subject'"'"'s tinnitus symptoms; selecting therapeutic sounds based on the determined tinnitus symptoms, wherein each therapeutic sound consists of only one frequency, wherein the frequencies are audible to the subject, and wherein the frequencies are outside of one or more tinnitus frequencies characterizing the subject'"'"'s tinnitus symptoms; presenting the therapeutic sounds paired with vagus nerve stimulation by presenting a vagus nerve stimulation pulse train during presentation of an individual therapeutic sound, wherein the vagus nerve stimulation pulse train is generated by a subcutaneous device that provides electrical stimulation of the subject'"'"'s vagus nerve; repeating the presentation of the plurality of paired therapeutic sounds; and reducing the subject'"'"'s perception of tinnitus. - View Dependent Claims (62, 63, 64, 65, 66, 67, 68, 69, 70, 71)
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72. A method of treating tinnitus in a subject, comprising:
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assessing a subject'"'"'s tinnitus symptoms; implementing a tinnitus treatment process on the subject comprising; selecting a therapeutic sound based on the assessed tinnitus symptoms, wherein the selected therapeutic sound consists of only one frequency; pairing the therapeutic sound with a vagus nerve stimulation pulse train originating from a device that provides electrical stimulation to the vagus nerve; repeating the tinnitus treatment process; and reducing the subject'"'"'s perception of tinnitus. - View Dependent Claims (73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83)
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84. A method of treating tinnitus in a patient, comprising:
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assessing a patient'"'"'s tinnitus symptoms; implementing a tinnitus treatment process comprising; selecting a sound based on the assessed tinnitus symptoms, wherein the selected sound consists of only one frequency; and presenting the sound to the patient while stimulating the patient'"'"'s vagus nerve with a device that provides electrical stimulation to the vagus nerve; repeating the tinnitus treatment process; and reducing the patient'"'"'s perception of tinnitus. - View Dependent Claims (85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99)
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Specification