Differential neurostimulation therapy driven by physiological therapy

• US 8,934,980 B2
• Filed: 03/04/2013
• Issued: 01/13/2015
• Est. Priority Date: 04/05/2000
• Status: Expired due to Term

• Current Assignee: Neuropace Inc.
• Original Assignee: Neuropace Inc.
• Inventors: Pless, Benjamin D., Tcheng, Thomas K.
• Primary Examiner(s): GETZOW, SCOTT M
• Application Number:
  US13/784,569
• Publication Number:
  US 20130184780A1
• Time in Patent Office: 680 Days
• Field of Search: 607/45, 607/32, 607/60, 607/59
• US Class Current: 607/45
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/4812 Detecting sleep stages or cycles
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61B 5/743 Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole
• CPC Class Codes: A61N 1/36064 Epilepsy
• CPC Class Codes: A61N 1/36067 : Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36078 : Inducing or controlling sleep or relaxation non-implantable stimulator A61M21/00
• CPC Class Codes: A61N 1/36135 : using physiological parameters
• CPC Class Codes: A61N 1/36139 : with automatic adjustment

Abstract

An implantable neurostimulator system adapted to provide therapy for various neurological disorders is capable of varying therapy delivery strategies based on the context, physiological or otherwise, into which the therapy is to be delivered. Responsive and scheduled therapies can be varied depending on various sensor measurements, calculations, inferences, and device states (including elapsed times and times of day) to deliver an appropriate course of therapy under the circumstances.

Claims

1. An implantable medical device system comprising:

an implantable medical device configured to acquire EEG signals from a patient, to detect a neurological event of interest based on one or more EEG parameters derived from the EEG signals, and to store in a memory, a representation of the EEG signals, together with the one or more EEG parameters;

an external component provided with a software operating program and associated hardware and configured to process, store, playback and display on a display of the external component the representation of the EEG signals and the one or more EEG parameters stored in the memory of the implantable medical device; and

a communication link configured to establish communication between a communications subsystem of the implantable medical device and the external component to enable the external component to process, store, playback and display on the display of the external component the representation of the EEG signals acquired and stored in the implantable medical device;

wherein the software operating program and associated hardware of the external component is configured to process the EEG signals received from the implantable medical device in order to simulate the detection of the neurological event.

2. The implantable medical device system of claim 1 wherein the communication link is a wireless link configured using a short distance first link between the implantable medical device and a transceiver, and the transceiver is configured to relay communications between the implantable medical device and the external component.

3. The implantable medical device system of claim 1 wherein the communication link is a wireless link configured using a long distance first link between the implantable medical device and a transceiver, and the transceiver is configured to relay information between the implantable medical device and the external component.

4. The implantable medical device system of claim 1 wherein the implantable medical device is further configured to acquire information corresponding to signal activity sensed by at least one sensor in operable communication with the implantable medical device, and the software operating program and associated hardware of the external component is further configured to process the signal activity received from the implantable medical device in order to simulate the detection and prediction of sensor signal activity representative of movement disorders based on a predetermined template developed for the patient.

5. The implantable medical device system of claim 1 wherein the implantable medical device is further configured with at least one analysis tool configured to derive the EEG parameters, and the software operating program and associated hardware of the external component is further configured to at least one of process, store, playback and display on the display of the external component the neurological event detected in the EEG signals based on the derived EEG parameters.

6. The implantable medical device system of claim 1 wherein the implantable medical device is further configured with operational parameters stored in the memory of the implantable medical device, and the software operating program and associated hardware of the external component is further configured to at least one of process, store, playback and display the operational parameters on the display of the external component.

7. The implantable medical device system of claim 1 wherein the display of EEG parameters on the external component may be directly associated with the display of the representation of the EEG signals.

8. The implantable medical device system of claim 1 wherein the display of EEG parameters on the display of the external component may be indirectly associated with the display of the representation of the EEG signals.

9. The implantable medical device system of claim 1, the implantable medical device further configured with:

a therapy subsystem provided with at least one of a therapeutic stimulator, a sensory stimulator, and a diagnostic stimulator, wherein each of the therapeutic stimulator, the sensory stimulator and the diagnostic stimulator is configured to deliver a form of neuromodulation to the neural tissue of a patient, the form of neuromodulation characterized by one or more therapy parameters;

a memory subsystem including the memory in which the representation of the EEG signals and the EEG parameters are stored and other memory in which the therapy parameters, if any, are stored, and

the software operating program and associated hardware of the external component is further configured to at least one of process, store, playback and display on the display of the external component at least the representation of the EEG signals, the neurological event detected in the EEG signals based on the derived EEG parameters, if any, and the form of neuromodulation delivered, if any, based on the therapy parameters.

10. The implantable medical device system of claim 9, further comprising an adaptive subsystem configured to do one of the following based on the EEG parameters, if any:

correlate or decorrelate the form of neuromodulation therapy based on one or more of the derived parameters.

11. The implantable medical device system of claim 1, wherein the external component is further configured to process the EEG parameters to derive a characteristic of the EEG signals.

12. The implantable medical device system of claim 11, wherein the EEG parameter comprises half-wave measurements and the derived characteristic is frequency content information.

13. The implantable medical device system of claim 11, wherein the EEG parameter comprises line length measurements and the derived characteristic is signal variation information.

14. The implantable medical device system of claim 11, wherein the EEG parameter comprises area measurements and the derived characteristic is energy information.

15. A method of communicating information between an implantable neurostimulator and at least one external component configured to process, store, playback and display on a display of the external component a representation of EEG signals acquired and stored in the implantable neurostimulator, comprising:

acquiring signal activity from the patient'"'"'s brain from at least one sensor, the at least one sensor in operable communication with the implantable neurostimulator;

processing the signal activity with the implantable neurostimulator to provide a digital representation of the signal activity, and to detect a neurological event of interest based on one or more signal parameters derived from the signal activity;

storing the digital representation of the signal activity, together with the one or more signal parameters, in an area of memory in a memory subsystem of the implantable neurostimulator;

establishing a communication link between the implantable neurostimulator and the external component and communicating through the communication link the digital representation of the signal activity from the area of memory to the external component; and

with a software operating program and associated hardware of the external component, processing and displaying on a display of the external component the representation of the signal activity and the signal parameters received from the implantable medical device, and processing the signal activity in order to simulate the detection of the neurological event.