Minute ventilation-based disordered breathing detection
First Claim
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1. A method for detecting disordered breathing implemented by an implantable device and at least in part within a patient, comprising:
- the implantable device having a processor, the processor configured to execute instructions for;
detecting a respiration pattern of a plurality of respiration cycles;
determining breath intervals (BI) and tidal volume (TVOL) measurements of each of the respiration cycles;
producing an unevenly sampled instantaneous minute ventilation (iMV) signal using the BI and TVOL measurements;
producing an evenly sampled iMV signal using the unevenly sampled iMV signal;
determining if each respiration cycle meets predetermined quality criteria for the iMV based at least in part on a short term average MV signal value, a long term moving average MV signal value, and a predetermined quality threshold; and
detecting disordered breathing based on a comparison between a baseline threshold and the resampled iMV signal using only respiration cycles that meet the predetermined quality criteria;
wherein the baseline threshold corresponds to a current midterm baseline threshold, and wherein an updated midterm baseline threshold is periodically calculated using a weighted short term average MV signal value and a weighted previous midterm baseline value; and
one or more of a cardiac rhythm management device, a drug delivery device, and a neurostimulation device delivering therapy to the patient based on the detected disordered breathing.
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Abstract
A respiration pattern of a number of respiration cycles is detected and breath intervals (BI) and tidal volume (TVOL) measurements of each of the respiration cycles are respectively determined. An unevenly sampled instantaneous minute ventilation (iMV) signal is produced using the BI and TVOL measurements, and an evenly sampled iMV signal (resampled iMV signal) is produced using the unevenly sampled iMV signal. Disordered breathing is detected based on a comparison between a baseline threshold and the resampled iMV signal.
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Citations
22 Claims
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1. A method for detecting disordered breathing implemented by an implantable device and at least in part within a patient, comprising:
the implantable device having a processor, the processor configured to execute instructions for; detecting a respiration pattern of a plurality of respiration cycles; determining breath intervals (BI) and tidal volume (TVOL) measurements of each of the respiration cycles; producing an unevenly sampled instantaneous minute ventilation (iMV) signal using the BI and TVOL measurements; producing an evenly sampled iMV signal using the unevenly sampled iMV signal; determining if each respiration cycle meets predetermined quality criteria for the iMV based at least in part on a short term average MV signal value, a long term moving average MV signal value, and a predetermined quality threshold; and detecting disordered breathing based on a comparison between a baseline threshold and the resampled iMV signal using only respiration cycles that meet the predetermined quality criteria; wherein the baseline threshold corresponds to a current midterm baseline threshold, and wherein an updated midterm baseline threshold is periodically calculated using a weighted short term average MV signal value and a weighted previous midterm baseline value; and one or more of a cardiac rhythm management device, a drug delivery device, and a neurostimulation device delivering therapy to the patient based on the detected disordered breathing. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An implantable device for detecting disordered breathing at least in part within a patient, comprising:
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an implantable housing; a sensor system disposed in the housing and configured to detect a respiration pattern of a plurality of respiration cycles; and a processor coupled to the sensor system, the processor configured to execute program instructions to; determine breath intervals (BI) and tidal volume (TVOL) measurements of each of the respiration cycles, produce an unevenly sampled instantaneous minute ventilation (iMV) signal using the BI and TVOL measurements, produce an evenly sampled iMV signal using the unevenly sampled iMV signal, detect disordered breathing based on a comparison between a baseline threshold and the resampled iMV signal, determine if each respiration cycle meets predetermined quality criteria for calculating the iMV based at least in part on a weighted short term average MV signal value, a long term moving average MV signal value, and a predetermined threshold, and produce, only for each respiration cycle that meets the predetermined quality criteria for purposes of detecting disordered breathing, the iMV signal and the resampled iMV signal, wherein the baseline threshold is calculated using only breaths that meet the predetermined quality criteria and disordered breathing is detected using only breaths that meet the predetermined quality criteria; and the implantable device is configured to implement one or more of cardiac rhythm management, drug delivery and neurostimulation therapy based on the detected disordered breathing. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A device for detecting disordered breathing implemented at least in part within a patient, comprising:
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a sensor configured to detect a respiration pattern of a plurality of respiration cycles; circuitry for determining breath intervals (BI) and tidal volume (TVOL) measurements of each of the respiration cycles; means for producing an unevenly sampled instantaneous minute ventilation (iMV) signal using the BI and TVOL measurements; means for producing an evenly sampled iMV signal (resampled iMV signal) using the unevenly sampled iMV signal; means for determining if each respiration cycle meets predetermined quality criteria for calculating the iMV by comparing a weighted short term average MV signal value and a longer term moving average MV signal value to a predetermined threshold; means for producing, only for each respiration cycle that meets the predetermined quality criteria for purposes of detecting disordered breathing, the iMV signal and the resampled iMV signal; and a detector configured to detect disordered breathing based on a comparison between a baseline threshold and the resampled iMV signal, wherein the baseline threshold is calculated using only breaths that meet the predetermined quality criteria and disordered breathing is detected using only breaths that meet the predetermined quality criteria.
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Specification