Acoustically controlled reaction device

• US 8,936,590 B2
• Filed: 03/09/2006
• Issued: 01/20/2015
• Est. Priority Date: 11/09/2005
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Hood, Leroy E., Ishikawa, Muriel Y., Jung, Edward K. Y., Langer, Robert, Tegreene, Clarence T., Wood, Lowell L. Jr., Wood, Victoria Y. H.
• Primary Examiner(s): Mehta, Bhisma
• Assistant Examiner(s): OSINSKI, BRADLEY JAMES
• Application Number:
  US11/372,226
• Publication Number:
  US 20070147170A1
• Time in Patent Office: 3,239 Days
• Field of Search: 604/20, 604/890.1, 604/891.1, 604 65- 67, 366/127, 366/108, 366/348, 366/116, 366/142
• US Class Current: 604/891.1
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 2205/0266 Shape memory materials
• CPC Class Codes: A61M 2205/0288 Electro-rheological or magneto-rheological materials
• CPC Class Codes: A61M 2205/3507 with implanted devices, e.g. external control
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/36 related to heating or cooling
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

Embodiments of a system including a remotely controlled reaction device and associated controller are described. Methods of use and control of the device are also disclosed. According to various embodiments, a reaction device is placed in an environment in order to perform a chemical reaction in an environment. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. In selected embodiments, an acoustic control signal may be used.

Claims

1. A reaction system comprising:

a body structure adapted for positioning in an environment, the body structure having an interior and an exterior;

a reaction region located within the interior of the body structure or on the exterior of the body structure, the reaction region including a first material configured to influence a chemical reaction at the reaction region; and

a remotely activatable control element operably coupled to the body structure and responsive to an acoustic control signal to modify an ability of the first material to influence one or more of the rate or kinetics of the chemical reaction;

wherein the first material is a catalyst that facilitates the chemical reaction but is not significantly modified by the chemical reaction.

2. The reaction system of claim 1, wherein the remotely activatable control element includes a polymer and an acoustically reactive component.

3. The reaction system of claim 2, wherein the acoustically reactive component is configured to be heated by action of the acoustic control signal, and wherein heating of the acoustically reactive component causes the polymer to undergo a change in configuration that modifies the influence of the first material on the chemical reaction.

4. The reaction system of claim 1, including a remote controller configured to generate an acoustic control signal sufficient to activate the remotely activatable control element to modify one or more of the rate or kinetics of the chemical reaction.

5. The reaction system of claim 1, wherein the remotely activatable control element responds to the control signal by changing in at least one dimension.

6. The reaction system of claim 5, wherein the remotely activatable control element includes at least one of a shape memory material or bimetallic structure.

7. The reaction system of claim 5, wherein additional portions of the reaction region are exposed responsive to the change in at least one dimension of the remotely activatable control element.

8. The reaction system of claim 7, wherein exposure of additional portions of the reaction region exposes additional functional groups to produce at least a local change in osmolality or pH.

9. The reaction system of claim 7, wherein exposure of additional portions of the reaction region exposes additional functional groups to produce at least a local change in a surface energy.

10. The reaction system of claim 7, wherein exposure of additional portions of the reaction region exposes additional functional groups to produce at least a local change in a surface charge.

11. The reaction system of claim 5, wherein a surface area of the reaction region is increased responsive to the change in at least one dimension of the remotely activatable control element.

12. The reaction system of claim 5, wherein a volume containing the reaction region within the interior portion of the body structure is increased responsive to the change in at least one dimension of the remotely activatable control element.

13. The reaction system of claim 1, wherein the environment is selected from a body of an organism, a body of an animal, a body of a human, a body of a plant, a body of water, a contained fluid volume, an industrial fluid volume, an agricultural fluid volume, a swimming pool, an aquarium, a drinking water supply, and an HVAC system cooling water supply.

14. The reaction system of claim 1, wherein the remotely activatable control element responds to the control signal by at least one of producing heating, producing cooling, changing shape, changing configuration, changing volume, changing surface area, or changing orientation.

15. The reaction system of claim 1, including at least one of an outlet through which a product of the chemical reaction is released into the environment or an inlet through which a second material configured to participate in the chemical reaction enters the reaction region.

16. The reaction system of claim 1, wherein the remotely activatable control element modifies one or more of the rate or reaction kinetics of the chemical reaction by modifying the influence of the first material on the chemical reaction.

17. The reaction system of claim 1, wherein the remotely activatable control element modifies one or more of the rate or reaction kinetics of the chemical reaction by modifying the rate of exposure of a reactant configured to participate in the chemical reaction to the first material.

18. The reaction system of claim 1, wherein the remotely activatable control element includes a polymer, ceramic, crystalline material, or combination thereof.

19. The reaction system of claim 1, wherein the remotely activatable control element is responsive to an ultrasonic acoustic signal.

20. The reaction system of claim 1, wherein the reaction region is located in an interior portion of the body structure and is at least intermittently in fluid communication with the environment via at least one inlet or outlet.

21. The reaction system of claim 1, wherein the reaction region is located on an exterior portion of the body structure in fluid communication with the environment.

22. The reaction system of claim 1, wherein the remotely activatable control element includes a valve element or a structural element.

23. The reaction system of claim 1, wherein the first material is non-reactant material that modifies at least one condition at which the reaction occurs.

24. The reaction system of claim 23, wherein the first material is a non-reactant material that modifies at least one of the magnetic polarity, the electric polarity, the osmolality, the pH, or the charge of at least a portion of the reaction region;

or a non-reactant material that includes a hydrophobic group, a hydrophilic group, an acid, an acidifier, a base, an alkalizer, a buffering agent, an enzyme, an antioxidant, a charge donor or a charge acceptor.

25. The reaction system of claim 1, wherein the catalyst includes at least one of a transition metal, an acid-base catalyst, a catalytic nucleic acid, an enzyme, an oxidoreductase, a transferase, a hydrolase, a lyase, an isomerase, a ligase, an enzymatic complexes or a cofactor.

26. The reaction system of claim 1, wherein the chemical reaction produces a material that has a beneficial effect on the organism or a local portion thereof.

27. The reaction system of claim 26, wherein the chemical reaction produces at least one of a nutrient, a hormone, a growth factor, a medication, a therapeutic compound, an enzyme, a genetic material, a vaccine, a vitamin, an imaging agent, a cell signaling material or neurotransmitter.

28. The reaction system of claim 1, wherein the chemical reaction destroys, traps, or sequesters a material from the body of the organism that is harmful to the organism or a portion thereof.

29. The reaction system of claim 28, wherein the chemical reaction includes at least one of degrading, chemically modifying, detoxifying, adsorbing, absorbing, enveloping, or killing the material by chemical reactions including at least one of enzymatic degradation and modification, antioxidant scavenging of free radicals, or adsorption with magnetically or electrically polarized particles for separation or sequestering.

30. The reaction system of claim 1, wherein the remotely activatable control element is responsive to the acoustic control signal to modify one or more of the rate or kinetics of the chemical reaction through at least one of a mechanical, thermal or chemical mechanism.

31. A reaction system comprising:

a body structure adapted for positioning in an environment, the body structure having an interior and an exterior;

a reaction region located within the interior of the body structure or on the exterior of the body structure, the reaction region including a first material configured to influence a chemical reaction at the reaction region, wherein the chemical reaction produces a material that has a beneficial effect on the organism or a local portion thereof; and

a remotely activatable control element operably coupled to the body structure and responsive to an acoustic control signal to modify an ability of the first material to influence one or more properties of the reaction region.

32. The reaction system of claim 31, wherein the chemical reaction produces at least one of a nutrient, a hormone, a growth factor, a medication, a therapeutic compound, an enzyme, a genetic material, a vaccine, a vitamin, an imaging agent, a cell signaling material or neurotransmitter.

33. The reaction system of claim 31, wherein the first material is a reactant that is modified by participation in the chemical reaction.

34. The reaction system of claim 31, wherein the first material is non-reactant material that modifies at least one condition at which the reaction occurs.

35. The reaction system of claim 31, wherein the first material is a catalyst that facilitates the chemical reaction but is not significantly modified by the chemical reaction.

36. A reaction system comprising:

a body structure adapted for positioning in an environment, the body structure having an interior and an exterior;

a reaction region located within the interior of the body structure or on the exterior of the body structure, the reaction region including a first material configured to influence a chemical reaction at the reaction region, wherein the chemical reaction traps or sequesters a material from the body of the organism that is harmful to the organism or a portion thereof; and

a remotely activatable control element operably coupled to the body structure and responsive to an acoustic control signal to modify an ability of the first material to influence one or more properties of the reaction region.

37. The reaction system of claim 36, wherein the first material is a reactant that is modified by participation in the chemical reaction.

38. The reaction system of claim 36, wherein the first material is non-reactant material that modifies at least one condition at which the reaction occurs.

39. The reaction system of claim 36, wherein the first material is a catalyst that facilitates the chemical reaction but is not significantly modified by the chemical reaction.

40. A reaction system comprising:

a body structure adapted for positioning in an environment, the body structure having an interior and an exterior;

a reaction region located within the interior of the body structure or on the exterior of the body structure, the reaction region including a first material configured to influence a chemical reaction at the reaction region, wherein the chemical reaction destroys a material within the body of the organism that is harmful to the organism or a portion thereof by degrading, chemically modifying, or detoxifying the material; and

a remotely activatable control element operably coupled to the body structure and responsive to an acoustic control signal to modify a temperature of the reaction region.