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Methods and apparatus for determining formulation orientation of multi-layered pharmaceutical dosage forms

  • US 8,936,810 B2
  • Filed: 10/18/2012
  • Issued: 01/20/2015
  • Est. Priority Date: 06/03/1998
  • Status: Expired due to Fees
First Claim
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1. A method of preparing a capsule-shaped tablet having a push end and a dispensing end for laser drilling of a delivery port in said dispensing end, wherein the tablet comprises adjacent first and second formulation layers each containing methylphenidate or a pharmaceutically acceptable salt thereof, and a further formulation layer not containing methylphenidate or a pharmaceutically acceptable salt thereof and being located at the push end of the tablet,the method comprising the steps of:

  • detecting the formulation orientation of the tablet by detecting the color at a spot location on a side of the tablet corresponding to one or another formulation layer depending on the formulation orientation of the tablet, wherein at least one layer contains a colorant;

    determining the formulation orientation of the tablet on the basis of the color detected;

    passing the tablets through a tablet rectifier wherein the orientation of any improperly oriented tablets is rectified and the orientation of any properly oriented tablets is maintained; and

    collecting the uniformly oriented tablets from said tablet rectifier for transportation to a laser drilling station.

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