Methods of loading a hollow stent with a drug or drug formulation
First Claim
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1. A method of loading a composition into a structural element of a stent, comprising;
- providing a stent having a structural element or providing a structural element that is to be used in forming a stent, the structural element defined by a lumen and least one opening to access the lumen;
heating the structural element to a temperature of about 30°
C. to about 60°
C.;
after heating the structural element, injecting a composition in a fluid state into the opening to load the lumen with the composition, wherein the composition comprises a therapeutic agent, and wherein the composition is in a solid state or a semi-solid state has at a temperature of 30°
C. and at one atmosphere; and
maintaining the structural element between about 30°
C. to about 60°
C. until the injection is completed.
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Abstract
A method of loading a composition into a structural element of a stent, where the structural element is defined by a lumen and at least one opening to access the lumen. The composition may comprise a therapeutic agent, and wherein at a temperature of 30° C. and at one atmosphere, the composition may be in a solid state or semi-solid state.
63 Citations
38 Claims
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1. A method of loading a composition into a structural element of a stent, comprising;
-
providing a stent having a structural element or providing a structural element that is to be used in forming a stent, the structural element defined by a lumen and least one opening to access the lumen; heating the structural element to a temperature of about 30°
C. to about 60°
C.;after heating the structural element, injecting a composition in a fluid state into the opening to load the lumen with the composition, wherein the composition comprises a therapeutic agent, and wherein the composition is in a solid state or a semi-solid state has at a temperature of 30°
C. and at one atmosphere; andmaintaining the structural element between about 30°
C. to about 60°
C. until the injection is completed. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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Specification