Fc variants with increased affinity for FcγRIIc
First Claim
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1. A protein comprising an Fc variant of a parent Fc polypeptide, said Fc variant comprising an amino acid substitution selected from the group consisting of 239D and 239E, wherein said Fc variant increases binding affinity to an Fcγ
- R as compared to said parent Fc polypeptide and wherein numbering is according to the EU index.
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Abstract
The present invention relates to Fc variants having increased affinity for FcγRIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
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Citations
8 Claims
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1. A protein comprising an Fc variant of a parent Fc polypeptide, said Fc variant comprising an amino acid substitution selected from the group consisting of 239D and 239E, wherein said Fc variant increases binding affinity to an Fcγ
- R as compared to said parent Fc polypeptide and wherein numbering is according to the EU index.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
Specification