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Fc variants with increased affinity for FcγRIIc

  • US 8,937,158 B2
  • Filed: 08/20/2007
  • Issued: 01/20/2015
  • Est. Priority Date: 03/03/2003
  • Status: Active Grant
First Claim
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1. A protein comprising an Fc variant of a parent Fc polypeptide, said Fc variant comprising an amino acid substitution selected from the group consisting of 239D and 239E, wherein said Fc variant increases binding affinity to an Fcγ

  • R as compared to said parent Fc polypeptide and wherein numbering is according to the EU index.

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