Systems and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling

• US 8,937,724 B2
• Filed: 12/10/2009
• Issued: 01/20/2015
• Est. Priority Date: 12/10/2008
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Vakoc, Benjamin J., Oh, Wang Y., Tearney, Guillermo J., Bouma, Brett E.
• Primary Examiner(s): Chowdhury, Tarifur
• Assistant Examiner(s): Lapage, Michael P
• Application Number:
  US12/635,435
• Publication Number:
  US 20100150422A1
• Time in Patent Office: 1,867 Days
• Field of Search: 356450-521
• US Class Current: 356/497
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: G01B 9/02008 by using a frequency comb
• CPC Class Codes: G01B 9/02079 Quadrature detection, i.e. detecting relatively phase-shifted signals
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence

Abstract

Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one sample. For example, using at least one first arrangement, it is possible to forward at least one first radiation to the sample(s) so as to cause at least one second radiation to be provided from the sample(s) that can be based on the first radiation(s). In addition, using at least one second arrangement, it is possible to receive the second radiation from the sample(s), generate a plurality of distinct measurements regarding at least one portion of the sample(s) based the second radiation(s), and characterize the portion(s) over a plurality of continuous resolvable depth points thereof which are associated with the distinct measurements. Further, the characterization of the at least one portion can be resolved and distinctly characterized at a number of the depth points which is greater than a number of the distinct measurements.

Claims

1. A system for generating data associated with at least one sample, comprising:

at least one first arrangement which is a light source configured to forward at least one first radiation having at least two different wavelengths to the at least one sample so as to cause at least one second radiation to be provided from the at least one sample that is based on the at least one first radiation; and

at least one second arrangement which is a detector configured to

receive the at least one second radiation from the at least one sample; and

at least one third arrangement which is a computer configure to generate a particular number (N) of measurements of at least one characteristic of at least one portion of the at least one sample; and

wherein each of the N measurements is generated by the computer as a function of a depth coordinate,

wherein a depth separation of each of the N measurements is at least a particular value (d), and

wherein the computer is further configured to characterize the at least one sample across a total physical depth range (R) that is greater than the product of N and d.

2. The system according to claim 1,

claim 1, further comprising an interferometer, which receives the at least one second radiation from the at least one sample and at least one third radiation from a structural reference arrangement, and interfere the second and third radiations to generate at least one interference signal,

wherein the computer is configured to generate the N measurements based on the at least one interference signal.

3. The system according to claim 1, wherein the at least one third arrangement is configured to:

a. generate at least one image of the at least one sample based on the N measurements, wherein the at least one image comprised a plurality of sections which are associated with respective multiple continuous segments of the at least one sample, and

b. connect at least two adjacent ones of the sections of the at least one image to one another to form at least one continuous and uninterrupted portion of the image associated with at least two respective ones of the segments.

4. The system according to claim 1, wherein the light source is configured to cause an optical spectrum of the first radiation to have a comb pattern with equal spacing in K.

5. The system according to claim 1, wherein the at least one first arrangement is configured to vary a wavelength of the at least one first radiation over time.

10. The system according to claim 1, wherein the light source is configured to cause an optical spectrum of the first radiation to have a comb pattern with equal spacing in K.

6. A method for generating data associated with at least one sample, comprising:

forwarding at least one first radiation having at least two different wavelengths to the at least one sample so as to cause at least one second radiation to be provided from the at least one sample that is based on the at least one first radiation;

receiving the at least one second radiation from the at least one sample, and

generating a particular number (N) of measurements of at least one characteristic of at least one portion of the at least one sample,

wherein the generation of each of the N measurements is performed as a function of a depth coordinate,

wherein a depth separation of each of the N measurements is at least a particular value (d), and

wherein the generation of N measurements includes characterizing the at least one sample across a total physical depth range (R) that is greater than the product of N and d.

7. A system for generating data associated with at least one sample, comprising:

at least one first arrangement which is a light source configured to forward at least one first radiation having at least two different wavelengths to the at least one sample so as to cause at least one second radiation to be provided from the at least one sample that is based on the at least one first radiation

at least one second arrangement which is a detector configured to

receive the at least one second radiation from the at least one sample; and

at least one third arrangement which is a computer configure to generate a particular number (N) of measurements of at least one characteristic of at least one portion of the at least one sample as a function wavelengths of the at least one first radiation

wherein each of the N measurements is generated by the computer as a function of a depth coordinate,

wherein a depth separation of each of the N measurements is at least a particular value (d), and

wherein the computer is further configured to characterize the at least one sample across a total physical depth range (R)that is greater than the product of N and d.

8. The system according to

claim 7, further comprising an interferometer, which receives the at least one second radiation from the at least one sample and at least one third radiation from a structural reference arrangement, and interfere the second and third radiations to generate at least one interference signal,

wherein computer is configured to generate the N measurements based on the at least one interference signal.

9. The system according to claim 7, wherein the at least one third arrangement is configured to:

a. generate at least one image of the at least one sample based on the N measurements, wherein the at least one image comprised a plurality of sections which are associated with respective multiple continuous segments of the at least one sample, and

b. connect at least two adjacent ones of the sections of the at least one image to one another to form at least one continuous and uninterrupted portion of the image associated with at least two respective ones of the segments.

11. The system according to claim 7, wherein the at least one first arrangement is configured to vary a wavelength of the at least one first radiation over time.

12. A system for generating data associated with at least one sample, comprising:

at least one first arrangement which is a light source configured to forward at least one first radiation to the at least one sample which has a wavelength that varies over time so as to cause at least one second radiation to be provided from the at least one sample that is based on the at least one first radiation; and

at least one second arrangement which is a detector configured to

receive the at least one second radiation from the at least one sample; and

at least one third arrangement which is a computer configure to generate a particular number (N) of measurements of at least one characteristic of at least one portion of the at least one sample as a function of wavelengths of the at least one first radiation,

wherein each of the N measurements is generated by the computer as a function of a depth coordinate,

wherein a depth separation of each of the N measurements is at least a particular value (d), and

wherein the computer is further configured to characterize the at least one sample across a total physical depth range (R) that is greater than the product of N and d.

13. The system according to

claim 12, further comprising an interferometer, which receives the at least one second radiation from the at least one sample and at least one third radiation from a structural reference arrangement, and interfere the second and third radiations to generate at least one interference signal, and

wherein the computer is configured to generate the N measurements based on the at least one interference signal.

14. The system according to claim 12, wherein the at least one third arrangement is configured to:

a. generate at least one image of the at least one sample based on the N measurements, wherein the at least one image comprised a plurality of sections which are associated with respective multiple continuous segments of the at least one sample, and

b. connect at least two adjacent ones of the sections of the at least one image to one another to form at least one continuous and uninterrupted portion of the image associated with at least two respective ones of the segments.

15. The system according to claim 12, wherein the light source is configured to cause an optical spectrum of the first radiation to have a comb pattern with equal spacing in K.